Racemic meroterpenoids from Ganoderma cochlear

Meroterpenoids from Ganoderma Species: A Review of Last Five Years

“…Thus, compounds 1 – 6 , and 9–13 had a ketone carbonyl at C-1′ and a carboxyl or methyl ester at C-10′ or C-14′ [ 15 , 16 , 30 – 35 ]. Among them, compounds 2 and 13 existed positional isomerization of olefinic bond because of the shift of the double bond at C-2′ and C-3′ [ 30 , 35 ], whereas, the reduction of the ∆ 2 ′ ,3 ′ in chizhine D ( 3 ), cochlearin G ( 4 ), applanatumols S, T ( 5 , 6 ) and ganomycin E ( 9 ) was occurred [ 30 , 31 , 34 ]. The C-14′ of ganomycin F ( 7 ) was connected to a hydroxyl group [ 16 ].…”

“…The of ganomycin J ( 9 ) was oxidized to two hydroxyls. Fornicin D ( 1 ), cochlearins H, G, I ( 2 , 4 , 12 ) and ganomycin C ( 11 ) isolated from Ganoderma cochlear , as well as ganomycins F and E ( 7 and 10 ) gained from G. capense , showed significant anti-oxidant activities [ 15 , 16 , 30 ]. Compound 3 was isolated from G. lucidum and displayed weak renoprotective effect [ 31 ].…”

“…For example, compounds 29 – 35 had different ether ring in the terpenoid part, whereas, the ether rings in compounds 36 – 40 were formed through a cyclization between the hydroxyl at C-1 and the hydroxyls of the terpenoid part. Compounds 29 , 30 , and 35 – 38 displayed significant antioxidant activities in the DPPH scavenging assay [ 16 , 30 ]. Among them, (±)-cochlearin D ( 30 ) and (+)- 30 exhibited weak inhibitory effects for the proliferation of hepatic stellate cells (HSCs) induced by transforming growth factor- β 1 (TGF- β 1) [ 30 ].…”

“…Compounds 29 , 30 , and 35 – 38 displayed significant antioxidant activities in the DPPH scavenging assay [ 16 , 30 ]. Among them, (±)-cochlearin D ( 30 ) and (+)- 30 exhibited weak inhibitory effects for the proliferation of hepatic stellate cells (HSCs) induced by transforming growth factor- β 1 (TGF- β 1) [ 30 ]. Except for above compounds, the rest of compounds didn’t show renoprotective activities [ 32 , 33 ].…”

“…When ganomycin C ( 11 ) was the biosynthetic precusor, compounds 59 – 70 (Fig. 5 ) were formed through the cyclization between C-6′ and C-10′ [ 30 , 40 ]. Biological activity of all the GMs against COX-2 was evaluated in vitro, only ganotheaecoloid J ( 68 ) was found to have COX-2 inhibitory activity with an IC 50 value of 9.96 μM [ 40 ].…”