Race/Ethnicity-Specific Disparities in the Severity of Disease at Presentation in Adults with Ulcerative Colitis: A Cross-Sectional Study

Castaneda, Garland; Liu, Benny; Torres, Sharon; Bhuket, Taft; Wong, Robert J.

doi:10.1007/s10620-017-4733-5

Cited by 17 publications

(12 citation statements)

References 26 publications

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“…For instance, the family Odoribacteriaceae and genus Odoribacter are primary butyrate producers in the gut, and they have been negatively associated to severe forms of Crohns disease and Ulcerative Colitis in association with reduced butyrate metabolism [43][44][45]. Asian-Pacific Islanders possess significantly less Odoribacteriaceae and Odoribacter than Hispanics and Caucasians in both data sets, and severity of Ulcerative Colitis upon hospital admission has been shown to be significantly higher in Asian Americans [46]. Considering broader physiological roles, several ethnicity-associated taxa are primary gut anaerobic fermenters and methanogens [47,48] and associate with lower BMI and blood triglyceride levels [36,49].…”

Section: Discussionmentioning

confidence: 96%

Gut microbiota diversity across ethnicities in the United States

et al. 2018

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Composed of hundreds of microbial species, the composition of the human gut microbiota can vary with chronic diseases underlying health disparities that disproportionally affect ethnic minorities. However, the influence of ethnicity on the gut microbiota remains largely unexplored and lacks reproducible generalizations across studies. By distilling associations between ethnicity and differences in two US-based 16S gut microbiota data sets including 1,673 individuals, we report 12 microbial genera and families that reproducibly vary by ethnicity. Interestingly, a majority of these microbial taxa, including the most heritable bacterial family, Christensenellaceae, overlap with genetically associated taxa and form co-occurring clusters linked by similar fermentative and methanogenic metabolic processes. These results demonstrate recurrent associations between specific taxa in the gut microbiota and ethnicity, providing hypotheses for examining specific members of the gut microbiota as mediators of health disparities.

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Section: Discussionmentioning

confidence: 96%

Gut microbiota diversity across ethnicities in the United States

et al. 2018

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“…A study utilising survey data of over 60 000 persons across the United States found that those with self‐reported disability due to any medical condition were more like to be Hispanic or non‐Hispanic black, have public payer insurance and fewer doctor visits . A cross‐sectional study of 98 UC patients demonstrated that Hispanics and Asians had more severe disease on initial presentation . Worse outcomes occur in persons of minority racial and ethnic groups than in Caucasians in other chronic diseases as well .…”

Section: Discussionmentioning

confidence: 99%

Disability in inflammatory bowel disease patients is associated with race, ethnicity and socio‐economic factors

Agrawal

Cohen‐Mekelburg

Kayal

et al. 2019

Aliment Pharmacol Ther

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Background: Race, ethnicity and socio-economic status impact clinical outcomes in inflammatory bowel disease (IBD) patients. However, their impact on disability has not been studied. Aim:To determine the association between race, ethnicity and socio-economic factors with disability in IBD, using the validated IBD disability index (IBD-DI).Methods: Ambulatory IBD patients were enrolled at five academic centres participating in the New York Crohn's and Colitis Organization. We assessed the IBD-DI, and collected clinical and socio-economic data. Factors associated with moderate-tosevere disability (IBD-DI score > 35) on univariable analysis were tested in multivariable models with adjusted odds ratios (aOR) and 95% confidence intervals (CI) reported.Results: In this study, 323 patients (57.3% CD, 51.4% female) were enrolled; 17.7%were Hispanic, 17% were non-Hispanic black, 56.0% were non-Hispanic Caucasian and 9.3% belonged to non-Hispanic non-black minority races. However, 39.0% of patients were publicly insured and 38.4% of patients had low annual household income (<$50 000). 100 (31.0%) patients reported moderate-to-severe disability. On multivariable analysis, Hispanic ethnicity (aOR 2.7, 95% CI 1.3-5.6), non-Hispanic non-black minority race (aOR 3.5, 95% CI 1.3-8.9), public payer (aOR 2.1, 95% CI 1.1-4.0) and low annual household income (aOR 3.0, 95% CI 1.7-5.4) were associated with moderate-to-severe disability controlling for disease characteristics.Conclusions: IBD patients who are minorities, have public insurance, or low household income, are 2-3 times more likely to report moderate-to-severe disability independent of disease characteristics in the United States. Future studies are needed to study their complex relationship and to mitigate disability.

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“…For instance, the family Odoribacteraceae and genus Odoribacter are primary butyrate producers in the gut, and they have been negatively associated to severe forms of Crohn’s disease and Ulcerative Colitis in association with reduced butyrate metabolism (43–45). Asian-Pacific Islanders possess significantly less Odoribacteraceae and Odoribacter than Hispanics and Caucasians in both datasets, and severity of Ulcerative Colitis upon hospital admission has been shown to be significantly higher in Asian Americans (46). Considering broader physiological roles, several ethnicity-associated taxa are primary gut anaerobic fermenters and methanogens (47, 48), and associate with lower BMI and blood triglyceride levels (36, 49).…”

Section: Discussionmentioning

confidence: 99%

Gut Microbiota Diversity across Ethnicities in the United States

Brooks

Priya

Blekhman

et al. 2018

Preprint

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32Composed of hundreds of microbial species, the composition of the human gut 33 microbiota can vary with chronic diseases underlying health disparities that 34 disproportionally affect ethnic minorities. However, the influence of ethnicity on the gut 35 microbiota remains largely unexplored and lacks reproducible generalizations across 36 studies. By distilling associations between ethnicity and differences in two United States 37 based 16S gut microbiota datasets including 1,673 individuals, we report 12 microbial 38 genera and families that reproducibly vary by ethnicity. Interestingly, a majority of these 39 microbial taxa, including the most heritable bacterial family, Christensenellaceae, overlap 40 with genetically-associated taxa and form co-occurring clusters linked by similar 41 fermentative and methanogenic metabolic processes. These results demonstrate recurrent 42 associations between specific taxa in the gut microbiota and ethnicity, providing hypotheses 43 for examining specific members of the gut microbiota as mediators of health disparities. 44Here, we comprehensively examine connections between self-declared ethnicity and 68 gut microbiota differences across more than a thousand individuals sampled by the 69 American Gut Project (AGP, N=1375) (24) and the Human Microbiome Project (HMP, N=298) 70 (6). Previous studies demonstrated that human genetic diversity in the HMP associates with 71 differences in microbiota composition (25), and genetic population structure within the HMP 72 generally delineates self-declared ethnicity (20). Ethnicity was not found to have a 73 significant association with microbiota composition in a Middle Eastern population, 74 however factors such as lifestyle and environment that influence microbiota variation across 75 participants was homogenous compared to the ethnic, sociocultural, economic, and dietary 76 diversity found within the United States (26). While ethnic diversity is generally 77 underrepresented in current microbiota studies, evidence supporting an ethnic influence on 78 microbiota composition among first generation immigrants has been recently demonstrated 79 in a Dutch population (27). The goal of this examination is to evaluate, for the first time, if 80 there are reproducible differences in gut microbiota across ethnicities within an overlapping 81 United States population, as ethnicity is one of the key defining factors for health disparity 82 incidence in the United States. Lifestyle, dietary, and genetic factors all vary to different 83 degrees across ethnic groups in the United States, and it will require more even sampling of 84 ethnic diversity and stricter phenotyping of study populations to disentangle which factors 85 underlie ethnic microbiota variation in the AGP and HMP. 86 6 Results: 87 Microbiota are subtly demarcated by ethnicity 88We first evaluate gut microbiota distinguishability between AGP ethnicities (Fig 1A, 89 family taxonomic level, Asians-Pacific Islanders (N=88), Caucasians (N=1237), Hispanics 90 (N=37), and African Americ...

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Race/Ethnicity-Specific Disparities in the Severity of Disease at Presentation in Adults with Ulcerative Colitis: A Cross-Sectional Study

Cited by 17 publications

References 26 publications

Gut microbiota diversity across ethnicities in the United States

Gut microbiota diversity across ethnicities in the United States

Disability in inflammatory bowel disease patients is associated with race, ethnicity and socio‐economic factors

Gut Microbiota Diversity across Ethnicities in the United States

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