Race/ethnicity and cancer occurrence in systemic lupus erythematosus

Bernatsky, Sasha; Boivin, Jean François; Joseph, Lawrence; Manzi, Susan; Ginzler, Ellen M.; Urowitz, MB; Gladman, Dafna D.; Fortin, Paul R.; Gordon, Caroline; Barr, Susan G.; Edworthy, Steven M.; Bae, Sang Cheol; Petri, Michelle; Sibley, John; Isenberg, David; Rahman, Anisur; Steinsson, Kristján; Aranow, Cynthia; Dooley, MA; Gs, Alarcón; Hanly, John G.; Sturfelt, Gunnar; Nived, Ola; Pope, Janet; Ensworth, Stephanie; Rajan, Raghu; El-Gabalawy, Hani; McCarthy, Timothy J.; Pierre, Yvan St.; Clarke, Ann E.; Ramsey‐Goldman, Rosalind

doi:10.1002/art.21458

Cited by 48 publications

(32 citation statements)

References 9 publications

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“…In addition, blacks had elevated risks of vagina/vulva cancer and Asian/ Pacific Islanders were at increased risk of both NHL and vagina/vulva cancer. Only one other study has examined cancer risk by race in SLE patients and did not report increased overall cancer risk in any race/ethnic group other than non-Hispanic whites [54]. It should be noted that the proportion of non-white individuals in that cohort was relatively small, and that less than seven cancers total were observed among Hispanics and Asians in the cohort.…”

Section: Discussionmentioning

confidence: 84%

Cancer risk in a cohort of patients with systemic lupus erythematosus (SLE) in California

Parikh‐Patel

White

Allen

et al. 2008

Cancer Causes Control

120

153

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Objective-We conducted a retrospective cohort study to examine cancer risk in a large cohort of systemic lupus erythematosus (SLE) patients in California.Methods-The cohort consisted of individuals with SLE derived from statewide patient discharge data during the period 1991-2002. SLE patients were followed using cancer registry data to examine patterns of cancer development. Standardized incidence ratios (SlRs) and 95% CI were calculated to compare the observed to expected numbers of cancers based on age-, race-, and sex-specific incidence rates in the California population.Results-The 30,478 SLE patients were observed for 157,969 person-years. A total of 1,273 cancers occurred within the observation interval. Overall cancer risk was significantly elevated (SIR=1.14, 95% CI=1.07-1.20). SLE patients had higher risks of vagina/vulva (SIR=3.27, 95% CI=2.41-4.31) and liver cancers (SIR=2.70, 95% CI=1.54-4.24). Elevated risks of lung, kidney, and thyroid cancers and several hematopoietic malignancies were also observed. Individuals had significantly lower risks of several screenable cancers, including breast, cervix, and prostate.Conclusions-These data suggest that risks of several cancer types are elevated among SLE patients. Detailed studies of endogenous and exogenous factors that drive these associations are needed.The final publication is available at Sprinter via: http://dx

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Section: Discussionmentioning

confidence: 84%

Cancer risk in a cohort of patients with systemic lupus erythematosus (SLE) in California

Parikh‐Patel

White

Allen

et al. 2008

Cancer Causes Control

120

153

View full text Add to dashboard Cite

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“…Furthermore, much progress has been made already on the fourth objective (ie, to use this cohort to facilitate novel approaches to outcomes and specifi c risk factors in SLE). During this period of recruitment, two additional studies using this cohort have begun: the neuropsychiatric lupus study [ 23 , 24 ] and the prospective malignancy in SLE study [25][26][27][28]. Also, applications for additional studies using clinical data from the SLICC-RAS or biologic materials stored from patients are under consideration.…”

Section: Discussionmentioning

confidence: 99%

The SLICC inception cohort for atherosclerosis

Urowitz

Gladman²

2008

Curr Rheumatol Rep

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The Systemic Lupus Erythematosus International Collaborating Clinics (SLICC) is a group of rheumatologists and methodologists from 27 international centers who have a particular interest and expertise in systemic lupus erythematosus. Initially, its efforts focused on development and validation of disease activity and damage indices. In 2000, the SLICC Registry for Atherosclerosis was established to determine the incidence, prevalence, nature, and risk factors of atherosclerotic coronary artery disease in systemic lupus erythematosus. Risk factors for coronary artery disease at presentation to the cohort were reported, as well as their accumulation over the first few years. Development of the metabolic syndrome was also described. Among the first 1078 patients who entered the cohort, 61 vascular events have occurred in 47 patients who were older at diagnosis and more likely male and hypertensive than were the patients without vascular events. Additional studies using this cohort are ongoing.

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“…48 Interestingly, the available data suggest that breast cancer risk in SLE is not uniform across all races, but more pronounced for white women. 28,38,48 Lung cancer Several cohort studies have showed an increased risk of lung cancer in patients with SLE. 3,13,25,35,49,50 A recent study reported that although the histological distribution of cancers in the SLE group and general population were comparable, there was a potential increase in the incidence of rare cancers (such as bronchoalveolar and carcinoid).…”

Section: Breast Cancermentioning

confidence: 99%

Lupus and cancer

Gayed

Bernatsky

Ramsey‐Goldman

et al. 2009

Lupus

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Individuals with systemic lupus erythematosus (SLE) have an increased susceptibility to certain types of cancer. Of particular concern are haematologic malignancies, specifically non-Hodgkin lymphoma, where a three- to four-fold increased risk is seen in SLE, compared with the general population. There is some evidence that immunosuppressive exposures play a role, although there appear to be other factors driving the risk. Lupus disease activity, with resultant dysregulated lymphocyte proliferation, may itself be a mediator of the association between SLE and lymphoma. Aside from haematologic malignancy risk, lung cancer also is increased in SLE compared with the general population, and smoking likely drives this risk in large part. Last but not least, cervical dysplasia is a concern in women with SLE, particularly with exposure to immunosuppressants; routine screening for this complication should not be neglected.

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Race/ethnicity and cancer occurrence in systemic lupus erythematosus

Cited by 48 publications

References 9 publications

Cancer risk in a cohort of patients with systemic lupus erythematosus (SLE) in California

Cancer risk in a cohort of patients with systemic lupus erythematosus (SLE) in California

The SLICC inception cohort for atherosclerosis

Lupus and cancer

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