Race disparities in genetic alterations within Wilms tumor specimens

Apple, Annie; Neuzil, Kevin; Phelps, Hannah M.; Li, Bingshan; Lovvorn, Harold N.

doi:10.1016/j.jpedsurg.2021.02.030

Cited by 4 publications

(3 citation statements)

References 37 publications

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“…The findings of this study may also indicate that ethnic differences in clinical characteristics exist in medulloblastoma [ 14 , 15 ]. These ethnic disparities have also been observed in other embryonal tumors such as Wilm’s tumor and neuroblastoma endorsing the results of our study [ 25 , 26 ].…”

Section: Discussionsupporting

confidence: 91%

Molecular subgrouping of medulloblastoma in pediatric population using the NanoString assay and comparison with immunohistochemistry methods

et al. 2022

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Purpose Molecular subgrouping of medulloblastoma has become important due to its impact on risk group stratification. Immunohistochemistry (IHC) has been widely used but it has innate limitations. The NanoString assay has been proposed as an alternative method. This study aims to present the characteristics of medulloblastoma subgrouped by the NanoString assay and to compare the subgrouping results with the IHC method. Methods Pediatric patients with histological diagnosis of medulloblastoma who underwent surgery from 2007 to 2021 were included. Clinical characteristics, pathological findings were reviewed. Molecular subgrouping was performed by IHC and by NanoString nCounter Elements TagSets assay. Test for concordance between two methods was made. Results Among a total of 101 patients analyzed, subgrouping using the NanoString assay resulted in 14 (13.8%) WNT, 20 (19.8%) SHH, 18 (17.8%) Group 3, and 39 (38.6%) Group 4 subgroup cases. Survival analysis revealed the following from best to worse prognosis: WNT, Group 4, SHH, and Group 3. In SHH subgroup the large cell/anaplastic histology was present in 30% of cases. Seventy-one cases were analyzed for concordance between NanoString and IHC. Cohen’s kappa value indicated moderate agreement but identification of Groups 3 and 4 with IHC using NPR3 and KCNA1 markers exhibited poor results. Conclusions The NanoString assay of Korean medulloblastoma patients revealed a more aggressive clinical course in the SHH subgroup which may be explained by a higher proportion of large cell/anaplastic histology being present in this subgroup. IHC did not distinguish Group 3 or 4 accurately. The NanoString assay may represent a good alternative method for practical use in the clinical field.

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Section: Discussionsupporting

confidence: 91%

Molecular subgrouping of medulloblastoma in pediatric population using the NanoString assay and comparison with immunohistochemistry methods

et al. 2022

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“… 6 Although the prevalence of WT is only slightly elevated in Black patients, this population is disproportionally more likely to present with late‐stage disease according to the Therapeutically Applicable Research to Generate Effective Treatments registry. 7 While race is the main studied disparity in WT patients, health care disparities are much more complex and multifaceted than one variable alone. 8 The Surveillance of Epidemiology and End Results (SEER) database is one of the largest datasets describing cancer outcomes, representing roughly 30% of the United States population.…”

Section: Introductionmentioning

confidence: 99%

“…Wilms' tumor (WT) represents the most common renal cancer in the pediatric population with a predicted five‐year overall survival of 90% with multimodal therapy 6 . Although the prevalence of WT is only slightly elevated in Black patients, this population is disproportionally more likely to present with late‐stage disease according to the Therapeutically Applicable Research to Generate Effective Treatments registry 7 . While race is the main studied disparity in WT patients, health care disparities are much more complex and multifaceted than one variable alone 8 .…”

Section: Introductionmentioning

confidence: 99%

Effect of social disparities on 10 year survival in pediatric patients with Wilms' tumor

2022

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Background To stratify 10‐year survival outcomes by degree of social disparities in pediatric Wilms' tumor patients. We applied the Social Deprivation Index (SDI) to survival outcomes from the national SEER database to elucidate the effects of lower socioeconomics on cancer survival. Methods A retrospective cohort study was performed using the national Surveillance, Epidemiology, and End Results (SEER) oncology registry from 1975 to 2016 based on county‐level data. Pediatric patients (<18 years old) with a diagnosis of WT (C64.9) and confirmed based on histology codes (8960/8963) were included. SDI scores were calculated for each patient and initially divided into quintiles. Patients were delineated into high‐risk (>60th percentile/more deprived) or low‐risk (<60th percentile/less deprived) groups. Statistics were assessed using Fisher's exact test, Student's t ‐test, and Kaplan–Meier assessed survival differences with log‐rank test for trend. Results A total of 3406 patients were included with 1366 patients reported in the high‐risk group and 2040 patients in the low‐risk group. Quintile data demonstrated a stratification in survival based on socioeconomic status. Patients in more socially deprived counties were significantly ( p = 0.035) more likely to have worse overall survival compared with those living in less deprived areas at 10‐year (87.3% vs 89.3%) follow‐up. Conclusions 10‐year overall and cancer‐specific survival data for patients with Wilms' tumor stratify by socioeconomic lines. This represents an area that needs to be addressed in this pediatric oncologic population. Patients from more socially deprived areas have significantly worse 10‐year overall survival rates and noticeably different 10‐year cancer‐specific survival rates.

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Genome-Related Mechanisms Contributing to Differences in Alzheimer’s Disease Incidence Between White and Black Older US Adults

Kolpakov,

Yashkin,

Ukraintseva

et al. 2024

J. Racial and Ethnic Health Disparities

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Race disparities in genetic alterations within Wilms tumor specimens

Cited by 4 publications

References 37 publications

Molecular subgrouping of medulloblastoma in pediatric population using the NanoString assay and comparison with immunohistochemistry methods

Molecular subgrouping of medulloblastoma in pediatric population using the NanoString assay and comparison with immunohistochemistry methods

Effect of social disparities on 10 year survival in pediatric patients with Wilms' tumor

Genome-Related Mechanisms Contributing to Differences in Alzheimer’s Disease Incidence Between White and Black Older US Adults

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