Race as an Independent Risk Factor for Breast Cancer Survival: Breast Cancer Outcomes From the Medical College of Georgia Tumor Registry

Barcenas, Carlos H.; Wells, Jeremy; Chong, Daniel; French, J. T.; Looney, Stephen W.; Samuel, Thomas A.

doi:10.3816/cbc.2010.n.008

Cited by 20 publications

(29 citation statements)

References 15 publications

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“…In this study, we were not able to demonstrate any significant associations between BCS and lymph node positivity or extent of nodal disease for patients with early-stage disease. However, consistent with the findings of other publications, BCS was found to be associated with race, age, and outcomes, with a significant distinction in time to distant metastasis, disease free survival, and overall survival observed across the four BCS (18–20). Furthermore, a statistically significant association between tumor BCS and T stage was also identified.…”

Section: Discussionsupporting

confidence: 90%

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Are Breast Cancer Subtypes Prognostic for Nodal Involvement and Associated with Clinicopathologic Features at Presentation in Early-Stage Breast Cancer?

Jones

Neboori

et al. 2013

Ann Surg Oncol

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Purpose Breast cancer subtypes (BCS) determined from IHC staining have been correlated with molecular subtypes and associated with prognosis/outcomes, but there are limited data correlating these BCS and axillary node involvement. This study was conducted to assess whether BCS predicted for nodal metastasis or was associated with other clinical-pathologic features at presentation. Methods Stage I/II patients who underwent breast-conserving surgery and axillary surgical assessment with available tissue blocks underwent a institutional pathological review and construction of a tissue microarray(TMA). The slides were stained for ER/PR/HER2-neu for classification into BCS. Nodal involvement and other clinical-pathologic features were analyzed to assess associations between BCS and patient/tumor characteristics. Outcomes were calculated a function of BCS. Results The study cohort consisted of 453 patients(LA 48.6%, LB 16.1%, HER2 11.0%, TN 24.2%), of which 22%(n=113) were node+. There were no significant associations with BCS and pN stage, node positivity, or absolute number of nodes involved (all p>0.05). However, there were significant associations with subtype and age at presentation (< 0.001), method of detection (p=0.049), tumor histology (p<0.001), race (p=0.041), and tumor size (pT stage, p<0.001) by univariate and multivariate analysis. As expected, 10-year outcomes differed by BCS, with TN & HER2/neu subtypes having the worse overall(p=0.03), disease-free(p=0.03) and distant metastasis-free survival(p< 0.01). Conclusions Our findings suggest that there is a significant association between BCS and age, T stage, histology, method of detection and race, but no associations to predict nodal involvement. If additionally validated, these findings suggest that BCS should not strongly influence regional management considerations.

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Section: Discussionsupporting

confidence: 90%

“…The association between the BCS and race has been well described in the literature (18, 20, 30). African American patients are known to have an increased likelihood of TN breast cancer (15) as well as inferior overall and disease-free survival (18).…”

Section: Discussionmentioning

confidence: 84%

Are Breast Cancer Subtypes Prognostic for Nodal Involvement and Associated with Clinicopathologic Features at Presentation in Early-Stage Breast Cancer?

Jones

Neboori

et al. 2013

Ann Surg Oncol

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“…It is also well demonstrated that black patients were more likely to present with clinically-detected cancers rather than screen-detected cancer, and have delayed diagnoses compared to white patients (26). Many, but not all (30–32), studies found that black patients are more likely to have delayed treatment (26, 29, 33, 34) and are less likely to receive definitive primary therapy and adjuvant chemotherapy (34–38), hormonal therapy (30), radiation after lumpectomy (29, 39, 40) or mastectomy (41) than their white counterparts. While research on racial disparity in follow-up care has been sparse, it has been suggested that black patients may receive less medical monitoring or follow-up care (28).…”

Section: Discussionmentioning

confidence: 99%

Racial/ethnic differences in breast cancer survival by inflammatory status and hormonal receptor status: an analysis of the Surveillance, Epidemiology, and End Results data

Schinkel

Zahm

Jatoi

et al. 2014

Cancer Causes Control

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Background Compared to non-inflammatory breast cancer (non-IBC), inflammatory breast cancer (IBC) has less favorable survival and is more likely to be estrogen receptor (ER) and progesterone receptor (PR) negative. ER+/PR+ tumors, regardless of histology, have less favorable survival. While black women are more likely to have IBC and ER+/PR+ tumors than white women, it is unclear whether the racial disparity in survival is explained by these factors. The objective of this study was to assess racial/ethnic differences in breast cancer survival by inflammatory histology and hormone receptor status. Methods This study examined breast cancer mortality among non-Hispanic white (NHW), Hispanic white (HW), black, and Asian/Pacific Islander (API) women diagnosed between 1990 and 2004. Kaplan-Meier survival curves and Cox proportional hazard ratios (HRs) assessed the relationship between race/ethnicity and survival. Results Black women had significantly poorer survival than NHW women regardless of inflammatory histology and hormone receptor status. Compared to NHWs, the HRs for black women were 1.32 (95% CI 1.21–1.44), 1.43 (95% CI 1.20–1.69) and 1.30 (95% CI 1.16–1.47) for IBC, IBC with ER+/PR+, and with ER−/PR−, respectively. Similar HRs were found for non-IBC, non-IBC with ER+/PR=, and non-IBC with ER−/PR−. API women had significantly better survival than NHW women regardless of inflammatory histology and hormone receptor status. Conclusion Compared to NHW women, black women had poorer survival regardless of inflammatory status and hormone receptor status and API women had better survival. These results suggest that factors other than histology and hormone receptor status may play a role in racial/ethnic disparities in breast cancer survival.

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“…Currently, it is estimated that, on average, one in eight women will develop breast cancer in her lifetime [24]. Although progress has been made on breast cancer diagnosis and treatment, there are still many unexplored areas, particularly in cancer therapeutics.…”

Section: The Role Of Mirnas In Breast Cancermentioning

confidence: 99%

The Role of MicroRNAs in Breast Cancer Migration, Invasion and Metastasis

Tang

Ahmad

Sarkar

2012

IJMS

158

130

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MicroRNAs (miRNAs) are a major class of small, noncoding RNA molecules that regulate gene expression by targeting mRNAs to trigger either translational repression or mRNA degradation. They have recently been more widely investigated due to their potential role as targets for cancer therapy. Many miRNAs have been implicated in several human cancers, including breast cancer. miRNAs are known to regulate cell cycle and development, and thus may serve as useful targets for exploration in anticancer therapeutics. The link between altered miRNA signatures and breast cancer development and metastasis can be observed either through the loss of tumor suppressor miRNAs, such as let-7s, miR-30a/31/34a/125s/200s/203/205/206/342 or the overexpression of oncogenic miRNAs, such as miR-10b/21/135a/155/221/222/224/373/520c in breast cancer cells. Some of these miRNAs have also been validated in tumor specimens of breast cancer patients, underscoring their potential roles in diagnostics, as well as targets for novel therapeutics for breast cancer. In this review article, we will provide an overview and update of our current understanding of the mode of action of several of these well characterized miRNAs in breast cancer models. Therefore, better understanding of the gene networks orchestrated by these miRNAs may help exploit the full potential of miRNAs in regards to cancer diagnosis, treatment, and therapeutics.

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Race as an Independent Risk Factor for Breast Cancer Survival: Breast Cancer Outcomes From the Medical College of Georgia Tumor Registry

Cited by 20 publications

References 15 publications

Are Breast Cancer Subtypes Prognostic for Nodal Involvement and Associated with Clinicopathologic Features at Presentation in Early-Stage Breast Cancer?

Are Breast Cancer Subtypes Prognostic for Nodal Involvement and Associated with Clinicopathologic Features at Presentation in Early-Stage Breast Cancer?

Racial/ethnic differences in breast cancer survival by inflammatory status and hormonal receptor status: an analysis of the Surveillance, Epidemiology, and End Results data

The Role of MicroRNAs in Breast Cancer Migration, Invasion and Metastasis

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