Race and Gender Differences in the Associations Between Cadmium Exposure and Bone Mineral Density in US Adults

Xie, Ruijie; Liu, Yiliang; Wang, Jiusong; Zhang, Chenhao; Xiao, Meimei; Liu, Mingjiang; Zhang, Ya

doi:10.1007/s12011-022-03521-y

Cited by 30 publications

(21 citation statements)

References 37 publications

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“…Percentages were used to characterize categorical variables which were compared by c 2 testing. To evaluate the relationship between smoking status and infertility, multivariable logistic regression was performed and the odds ratio (OR) values and 95% confidence intervals (95%CI) were calculated (28)(29)(30)(31)(32). Three models were built for the multivariate test.…”

Section: Discussionmentioning

confidence: 99%

Associations between smoking status and infertility: a cross-sectional analysis among USA women aged 18-45 years

2023

Front. Endocrinol.

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BackgroundAlthough many studies have proven the harmful effects of smoking on human health, the associations between smoking status and infertility are limited in large epidemiologic studies. We aimed to investigate the associations between smoking status and infertility among child-bearing women in the United States of America (USA).MethodsA total of 3,665 female participants (aged 18-45) from the National Health and Nutrition Examination Survey (NHANES) (2013-2018) were included in this analysis. All data were survey-weighted, and corresponding logistic regression models were performed to investigate the associations between smoking status and infertility.ResultsIn a fully adjusted model, the risk of infertility was found to be increased by 41.8% among current smokers compared to never smokers (95% CI: 1.044-1.926, P=0.025). In the subgroup analysis, the odds ratios (95% CI) of the risk of infertility for current smokers were 2.352 (1.018-5.435) in the unadjusted model for Mexican American, 3.675 (1.531-8.820) in the unadjusted model but 2.162 (0.946-4.942) in fully adjusted model for people aged 25-31, 2.201 (1.097-4.418) in the unadjusted model but 0.837 (0.435-1.612) in fully adjusted model for people aged 32-38.ConclusionCurrent smokers was associated with a higher risk of infertility. The underlying mechanism of these correlations still needs more research. Our findings indicated that quitting smoking may serve as a simple index to reduce the risk of infertility.

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Section: Discussionmentioning

confidence: 99%

Associations between smoking status and infertility: a cross-sectional analysis among USA women aged 18-45 years

2023

Front. Endocrinol.

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“…Fiber intake was calculated as an average of 2 days, adjusted for body weight. [22] 2.3. Rheumatoid arthritis RA prevalence was assessed by 2 medical condition questionnaires and participants were considered to have RA if they answered "yes" to the question "Has your doctor ever told you have arthritis?"…”

Section: Fiber Intakementioning

confidence: 99%

Dietary fiber intake associated with risk of rheumatoid arthritis among U.S. adults: NHANES 2010-2020

Liu

Xie

2023

Medicine

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Rheumatoid arthritis (RA) is a prevalent inflammatory joint disease that imposes a significant medical burden and morbidity. Recent scientific evidence suggests that dietary components and patterns could be associated with RA risk. In this study, we aim to investigate the possible relationship between dietary fiber intake and RA risk. We included 15,114 participants from the 2010 to 2020 National Health and Nutrition Examination Survey database in our study. Participants aged 20 or above were categorized into those with and without RA. Univariate logistic regression analysis and multivariate regression models were used to test the association between dietary fiber intake, high-sensitivity C-reactive protein, and RA. Out of all the participants, 1053 were diagnosed with RA (6.97%). Multivariate logistic regression analysis indicated that fiber intake was negatively associated with high-sensitivity c-reactive protein (−0.09 [−0.18, −0.02]) and RA risk (0.99 [0.98, 0.99]). Furthermore, our sensitivity analysis suggested that individuals with higher fiber intake (>19.1 g/day) had a 25% lower risk of developing RA than those with lower fiber intake [0.75 (0.63, 0.88)]. Our findings suggest that higher dietary fiber intake is associated with a reduced risk of RA and may help reduce systemic inflammation, thereby potentially slowing down RA progression.

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“…However, the reasons behind the positive association between SES and BMD are complex and unexplained. Based on the available evidence, the negative effects of SES on BMD are thought to possibly stem from unhealthy lifestyles, including factors such as food insecurity ( 30 ), lack of essential nutrients ( 31 , 32 ), and exposure to harmful substances ( 33 ). Health outcomes of an unhealthy lifestyle, such as underweight ( 34 ) and visceral fat accumulation ( 35 , 36 ), may further negatively affect bone metabolism.…”

Section: Discussionmentioning

confidence: 99%

BMI, socioeconomic status, and bone mineral density in U.S. adults: Mediation analysis in the NHANES

Zhang

Tan²,

Tan³

2023

Front. Nutr.

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IntroductionThe mechanism by which socioeconomic status (SES) affects bone mineral density (BMD) remains unknown, and body mass index (BMI) may be a potential mediator. The purpose of this study was to investigate whether BMI mediates the relationship between SES [education level and poverty income ratio (PIR)] and lumbar BMD and the proportion it mediates.MethodsThis study included a total of 11,075 adults from the National Health and Nutrition Examination Survey (NHANES). Lumbar BMD was measured at the lumbar spine by dual-energy X-ray absorptiometry (DXA). Multivariate linear regression and smoothing curve fitting were used to investigate the relationship between SES and lumbar BMD. Mediator analysis was used to investigate the proportion of BMI mediating the association between SES and BMD.ResultsIn the fully adjusted model, there was a positive correlation between SES and BMD (education level: β = 0.025, 95% CI: 0.005, 0.045; PIR: β = 0.007, 95% CI: 0.002, 0.011). Mediation analysis showed that BMI mediated the relationship between PIR, education level, and lumbar BMD with a range of mediation proportions from 13.33 to 18.20%.ConclusionBMI partially mediated the positive association between SES and BMD, and this association may be largely mediated by factors other than BMI.

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Race and Gender Differences in the Associations Between Cadmium Exposure and Bone Mineral Density in US Adults

Cited by 30 publications

References 37 publications

Associations between smoking status and infertility: a cross-sectional analysis among USA women aged 18-45 years

Associations between smoking status and infertility: a cross-sectional analysis among USA women aged 18-45 years

Dietary fiber intake associated with risk of rheumatoid arthritis among U.S. adults: NHANES 2010-2020

BMI, socioeconomic status, and bone mineral density in U.S. adults: Mediation analysis in the NHANES

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