Raccoons (Procyon lotor), but not rodents, are natural and experimental hosts for an ehrlichial organism related to “Candidatus Neoehrlichia mikurensis”

Yabsley, Michael J.; Murphy, Staci M.; Luttrell, M. Page; Wilcox, Benjamin R.; Ruckdeschel, Carol

doi:10.1016/j.vetmic.2008.04.004

Cited by 19 publications

(28 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Neoehrlichia lotoris which had been detected in tick-infested raccoon populations (Procyon lotor) and was successfully isolated in the Ixodes scapularis-derived ISE6 tick cell line, and was formally described (Munderloh et al 2007;Yabsley et al 2008a). Interestingly, the culture was infectious for raccoons in further experiments but it did not produce a detectable infection in laboratory mice, rats or rabbits (Yabsley et al 2008b). The analysis of several gene loci showed that Ca.…”

Section: History Of Discoverymentioning

confidence: 98%

Neoehrlichiosis: an emerging tick-borne zoonosis caused by Candidatus Neoehrlichia mikurensis

et al. 2015

View full text Add to dashboard Cite

Candidatus Neoehrlichia mikurensis is an emerging tick-borne pathogen causing a systemic inflammatory syndrome mostly in persons with underlying hematologic or autoimmune diseases. As it is neither well-known nor well-recognized, it might be misdiagnosed as recurrence of the underlying disease or as an unrelated arteriosclerotic vascular event. The pathogen is transmitted by hard ticks of the genus Ixodes and is closely associated with rodents in which transplacental transmission occurs. Transovarial transmission in ticks has not yet been shown. Infection rates vary greatly in ticks and rodents, but the causes for its spatiotemporal variations are largely unknown. This review summarizes the current state of knowledge on the geographical distribution and clinical importance of Ca. N. mikurensis. By elucidating the life history traits of this pathogen and determining more accurately its incidence in the human population, a better assessment of its public health relevance can be made. Most urgent research needs are the in vitro-cultivation of the pathogen, the development of specific serological tests, the determination of the full genomic sequence, the routine implementation of molecular diagnosis in diseased patients with a particular panel of underlying diseases, and promoting the knowledge about neoehrlichiosis among general practitioners, hospital physicians and the risk groups such as forest workers or immune-compromised people to raise awareness about this disease that can easily be treated when correctly diagnosed.

show abstract

Section: History Of Discoverymentioning

confidence: 98%

Neoehrlichiosis: an emerging tick-borne zoonosis caused by Candidatus Neoehrlichia mikurensis

et al. 2015

View full text Add to dashboard Cite

show abstract

“…Rattus variant [6]; and Candidatus Ehrlichia walkerii [7]. The closest relative of C. Neoehrlichia mikurensis is the other species within the Neoehrlichia genus, Candidatus Neoehrlichia lotoris, the natural host of which is the raccoon [8].…”

Section: The Agentmentioning

confidence: 99%

“…However, a recent study showed that fetuses and newborn pups of C. Neoehrlichia mikurensis-infected wild rodents tested positive for C. Neoehrlichia mikurensis, suggesting that transplacental transmission of infection may occur [29]. Interestingly, rodents are refractory to infection with the other Neoehrlichia species, C. Neoehrlichia lotoris [8].…”

Section: CMImentioning

confidence: 99%

Infections with the tick-borne bacterium Candidatus Neoehrlichia mikurensis

Wennerås

2015

Clinical Microbiology and Infection

View full text Add to dashboard Cite

Candidatus Neoehrlichia mikurensis, which has rodents as its natural hosts, is an emerging tick-borne pathogen in Europe and Asia. This intracellular bacterium causes the infectious disease neoehrlichiosis. Immunocompromised patients may contract a severe form of neoehrlichiosis with high fever and vascular/thromboembolic events. As it is not detected with routine culture-based methods, neoehrlichiosis is underdiagnosed.

show abstract

“…Conversely, 'Candidatus N. lotoris' is only found in the North American racoon (Procyon lotor) and its associated tick species (Dugan et al, 2005;Munderloh et al, 2007;Yabsley et al, 2008a). It has not been detected in humans or any other vertebrate species in the wild, and laboratory rodents and rabbits are refractory to infection (Yabsley et al, 2008a).…”

Section: Introductionmentioning

confidence: 99%

“…It has not been detected in humans or any other vertebrate species in the wild, and laboratory rodents and rabbits are refractory to infection (Yabsley et al, 2008a). 'Candidatus Neoehrlichia lotoris' has been successfully cultured in the Ixodes scapularis ISE6 cell line (Munderloh et al, 2007), and although not empirically determined, several species of Ixodes tick endemic to southwest USA, including I. scapularis, are suspected vectors (Munderloh et al, 2007;Yabsley et al, 2008a).…”

Section: Introductionmentioning

confidence: 99%

Phylogenetic characterisation of two novel Anaplasmataceae from Australian Ixodes holocyclus ticks: ‘Candidatus Neoehrlichia australis' and ‘Candidatus Neoehrlichia arcana'

Gofton

Doggett

Ratchford

et al. 2016

International Journal of Systematic and Evolutionary Microbiology

View full text Add to dashboard Cite

Raccoons (Procyon lotor), but not rodents, are natural and experimental hosts for an ehrlichial organism related to “Candidatus Neoehrlichia mikurensis”

Cited by 19 publications

References 16 publications

Neoehrlichiosis: an emerging tick-borne zoonosis caused by Candidatus Neoehrlichia mikurensis

Neoehrlichiosis: an emerging tick-borne zoonosis caused by Candidatus Neoehrlichia mikurensis

Infections with the tick-borne bacterium Candidatus Neoehrlichia mikurensis

Phylogenetic characterisation of two novel Anaplasmataceae from Australian Ixodes holocyclus ticks: ‘Candidatus Neoehrlichia australis' and ‘Candidatus Neoehrlichia arcana'

Contact Info

Product

Resources

About