Raccomandazioni del GdS MM SIPMeL per l'uso dei biomarcatori cardiaci nella diagnostica di NSTEMI. Parte prima: cosa dicono le linee guida

Serial measurements of cardiac troponin are recommended by international guidelines to diagnose myocardial infarction (MI) since 2000. However, some relevant differences exist between the three different international guidelines published between 2020 and 2021 for the management of patients with chest pain and no ST-segment elevation. In particular, there is no agreement on the cut-offs or absolute change values to diagnose non-ST-segment elevation MI (NSTEMI). Other controversial issues concern the diagnostic accuracy and cost-effectiveness of cut-off values for the most rapid algorithms (0 h/1 h or 0 h/2 h) to rule-in and rule-out NSTEMI. Finally, another important point is the possible differences between demographic and clinical characteristics of patients enrolled in multicenter trials compared to those routinely admitted to the Emergency Department in Italy. The Study Group of Cardiac Biomarkers, supported by the Italian Scientific Societies Società Italiana di Biochimica Clinica, Italian Society of the European Ligand Assay Society, and Società Italiana di Patolgia Clinica e Medicina di Laboratorio decided to revise the document previously published in 2013 about the management of patients with suspected NSTEMI, and to provide some suggestions for the use of these biomarkers in clinical practice, with a particular focus on the Italian setting.

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Use of high-sensitivity cardiac troponins in the emergency department for the early rule-in and rule-out of acute myocardial infarction without persistent ST-segment elevation (NSTEMI) in Italy

Clerico

Zaninotto

Aimo

et al. 2021

Clinical Chemistry and Laboratory Medicine (CCLM)

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Raccomandazioni del GdS MM SIPMeL per l'uso dei biomarcatori cardiaci in NSTEMI. Parte seconda: evidenze nella diagnosi

et al. 2021

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Raccomandazioni del GdS MM SIPMeL per l'uso dei marcatori miocardiaci nella diagnostica di NSTEMI. Parte terza: prognosi e stratificazione del rischio

Malloggi¹,

Cappelletti²,

Burgio³

et al. 2021

Riv Ital Med Lab

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Raccomandazioni del GdS MM SIPMeL per l'uso dei biomarcatori cardiaci nella diagnostica di NSTEMI. Parte prima: cosa dicono le linee guida

Cited by 9 publications

References 79 publications

Use of high-sensitivity cardiac troponins in the emergency department for the early rule-in and rule-out of acute myocardial infarction without persistent ST-segment elevation (NSTEMI) in Italy

Use of high-sensitivity cardiac troponins in the emergency department for the early rule-in and rule-out of acute myocardial infarction without persistent ST-segment elevation (NSTEMI) in Italy

Raccomandazioni del GdS MM SIPMeL per l'uso dei biomarcatori cardiaci in NSTEMI. Parte seconda: evidenze nella diagnosi

Raccomandazioni del GdS MM SIPMeL per l'uso dei marcatori miocardiaci nella diagnostica di NSTEMI. Parte terza: prognosi e stratificazione del rischio

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