Rabies research in Ethiopia: A systematic review

Gelgie, Aga E.; Cavalerie, Lisa; Kaba, Mirgissa; Asrat, Daniel; Mor, Siobhan M.

doi:10.1016/j.onehlt.2022.100450

Cited by 2 publications

(3 citation statements)

References 37 publications

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“…The study revealed that the pooled prevalence of a good level of rabies knowledge was estimated to be 62.24%, with individual estimates ranging from 7.50% ( 39 ) in the Addis Ababa survey to 99.25% in the Gondar Zuria area ( 51 ). The present combined prevalence of a good level of knowledge about rabies is congruent with a recent systematic review in Ethiopia ( 57 ), individual study reports in Nigeria ( 58 ), and Morocco ( 59 ) and is higher than research reports from Thailand (52.1%) ( 60 ), Mozambique, Limpopo National Park (18.9%), Bangladesh (58%) ( 61 ), and China (56.85%) ( 62 ). Such a level of adequate rabies knowledge in Ethiopia is not surprising, given that dog-mediated rabies cases were reported up to an estimated cumulative incidence of 89.8 per 100,000 population in the Tigray region of northern Ethiopia ( 6 ) and dog-mediated rabies is endemic in our country.…”

Section: Discussionsupporting

confidence: 89%

“…An estimated 60% of dog victims visit traditional healers ( 35 , 49 ) for herbal use and water locally called ‘ Tsebel ’ ( 51 ). As also pointed out in a recent systematic review by Gelgie et al ( 57 ), we did not find rabies research reports from the Gambela, Benishangul-Gumuz, Afar, and Harai regions or the Dire Dawa city administration. Subgroup meta-analysis based on region revealed the highest level of good knowledge (63%) was reported from the Amhara region, while favorable attitudes (70%) and good prevention practices (70%) were reported from SNNPRs.…”

Section: Discussionsupporting

confidence: 70%

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Knowledge, attitudes and prevention practices related to dog-mediated rabies in Ethiopia: a systematic review and meta-analysis of observational epidemiological studies from inception to 2023

Woldegeorgis,

Genebo,

Gebrekidan

et al. 2023

Front. Public Health

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BackgroundRabies is a horrific and neglected zoonotic disease that kills thousands of people worldwide each year and continues to pose threats to public health. Prevention and control of dog-transmitted rabies require mapping the level of understanding, perception, and existing practices to minimize its impacts on health. Therefore, we undertook this systematic review and meta-analysis to pool evidence from available data on knowledge, attitudes, and prevention practices regarding the disease from studies conducted in various areas of Ethiopia.MethodsArticles were searched in electronic bibliographic medical databases such as the Excerpta Medica database, PubMed, Web of Science, African Journals Online, Google Scholar, and Scopus. We used Microsoft Excel spreadsheets and STATA software version 16 for the data excerption and analysis, respectively. The variability among studies was evaluated via Higgins and Thompson’s I2 statistics and the x2 test (significant at p ≤ 0.1). The Dersimonian and Laird random-effect meta-analysis model was used to estimate the pooled effect at a 95% uncertainty interval (UI). Visual inspection and Egger’s test (significant at p ≤ 0.05) were used to identify the presence of small-study effects.ResultsThe search identified 1,249 electronic records. Of them, 27 studies involving 11,150 participants met the inclusion criteria. The pooled prevalence of a good level of knowledge was 62.24% (95% UI: 48.56, 75.92). Furthermore, the pooled prevalence of a favorable level of attitudes towards rabies and a good level of rabies prevention practices was only 56.73% (95% UI: 47.16, 66.29) and 52.73% (95% UI: 43.32, 62.15), respectively.ConclusionThe study revealed credible gaps in attitudes and prevention practices, though some level of knowledge about dog-mediated rabies was demonstrated. Therefore, we call for country-wide cross-sectoral collaboration to allow for the realization of a global elimination strategy for dog-mediated human rabies.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionsupporting

confidence: 70%

Knowledge, attitudes and prevention practices related to dog-mediated rabies in Ethiopia: a systematic review and meta-analysis of observational epidemiological studies from inception to 2023

Woldegeorgis,

Genebo,

Gebrekidan

et al. 2023

Front. Public Health

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“…However, living with companion animals might increase the risk of bidirectional transmission of some infectious diseases. Indeed, cats and dogs have been identified as potential sources of zoonoses of varying severity in humans, including viral pathogens (such as rabies virus and norovirus) [8][9][10][11][12] , bacteria (such as Bordetella, Campylobacter and Salmonella) [13][14][15][16] , fungi (such as dermatophytes) 17 , as well as parasites (such as Toxoplasma gondii) 18 , causing human illnesses ranging from mild rashes to severe nerve damage 8 .…”

Section: Introductionmentioning

confidence: 99%

Meta-transcriptomic analysis of companion animal infectomes reveals their diversity and potential roles in animal and human disease

Wu,

Pan,

Zhou

et al. 2024

Preprint

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Companion animals such as cats and dogs harbor diverse microbial communities that can potentially impact human health due to close and frequent contact. To better characterize their total infectomes and assess zoonotic risks, we performed meta-transcriptomic profiling on 239 samples from cats and dogs collected across China, comparing the similarities and differences between animal species (cats or dogs), sampling sites (rectal or oropharyngeal), and health status (healthy or diseased). We identified 24 viral species, 270 bacterial genera, and two fungal genera, including many known pathogens such ascanine parvovirus,Clostridium difficile, andCandida albicans,as well as opportunistic pathogens such ascanine vesivirus. Microbial compositions differed mainly according to sampling site (i.e., rectal and oropharyngeal swabs), and less so between host species and health status. Notably, we detected 27 potential zoonotic pathogens, such asalphacoronavirus 1, among all sampling sites, hosts, and health status, underscoring substantial zoonotic risks requiring surveillance. Overall, our meta-transcriptomic analysis reveals a landscape of actively transcribing microorganisms in major companion animals, including key pathogens, those with the potential for cross-species transmission, and possible zoonotic threats.

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Rabies research in Ethiopia: A systematic review

Cited by 2 publications

References 37 publications

Knowledge, attitudes and prevention practices related to dog-mediated rabies in Ethiopia: a systematic review and meta-analysis of observational epidemiological studies from inception to 2023

Knowledge, attitudes and prevention practices related to dog-mediated rabies in Ethiopia: a systematic review and meta-analysis of observational epidemiological studies from inception to 2023

Meta-transcriptomic analysis of companion animal infectomes reveals their diversity and potential roles in animal and human disease

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