Rabies Antibodies in Sera of Wild Birds

Gough, Patricia M.; Jorgenson, Richard D.

doi:10.7589/0090-3558-12.3.392

Cited by 17 publications

(6 citation statements)

References 1 publication

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“…Overexpression of chIFITM3 resulted in 79.4% and 85% reductions in infection of A549s to lentivirus vectors pseudotyped with the lyssaviruses envelopes RABV and LBV, similar to the level of restriction by huIFITM3 to the same viruses ( Fig. 4A ), even though chickens are rarely infected by lyssaviruses ( 23 ). chIFITM2 also restricts lyssavirus LBV and RABV infection to a similar level as chIFITM3.…”

Section: Resultsmentioning

confidence: 62%

Chicken Interferon-Inducible Transmembrane Protein 3 Restricts Influenza Viruses and Lyssaviruses In Vitro

Smith

Gibson

Wash

et al. 2013

J Virol

137

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Interferon-inducible transmembrane protein 3 (IFITM3) is an effector protein of the innate immune system. It confers potent, cell-intrinsic resistance to infection by diverse enveloped viruses both in vitro and in vivo, including influenza viruses, West Nile virus, and dengue virus. IFITM3 prevents cytosolic entry of these viruses by blocking complete virus envelope fusion with cell endosome membranes. Although the IFITM locus, which includes IFITM1, -2, -3, and -5, is present in mammalian species, this locus has not been unambiguously identified or functionally characterized in avian species. Here, we show that the IFITM locus exists in chickens and is syntenic with the IFITM locus in mammals. The chicken IFITM3 protein restricts cell infection by influenza A viruses and lyssaviruses to a similar level as its human orthologue. Furthermore, we show that chicken IFITM3 is functional in chicken cells and that knockdown of constitutive expression in chicken fibroblasts results in enhanced infection by influenza A virus. Chicken IFITM2 and -3 are constitutively expressed in all tissues examined, whereas IFITM1 is only expressed in the bursa of Fabricius, gastrointestinal tract, cecal tonsil, and trachea. Despite being highly divergent at the amino acid level, IFITM3 proteins of birds and mammals can restrict replication of viruses that are able to infect different host species, suggesting IFITM proteins may provide a crucial barrier for zoonotic infections.

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Section: Resultsmentioning

confidence: 62%

Chicken Interferon-Inducible Transmembrane Protein 3 Restricts Influenza Viruses and Lyssaviruses In Vitro

Smith

Gibson

Wash

et al. 2013

J Virol

137

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“…At a larger scale, rabies virus has a taxonomic signature, and even with a diversity of potential hosts, the virus can be perpetuated only in mammalian hosts, mainly Carnivora and Chiroptera. Thus, rabies is not distributed at random among all taxa and the physiological features of hosts have an environmental pattern for the virus that may be tractable ( Gough and Jorgenson, 1976 ). Rabies virus can also have a landscape level signature.…”

Section: Environmental Variables Used In Ecological Niche Modelingmentioning

confidence: 99%

Advances and Limitations of Disease Biogeography Using Ecological Niche Modeling

2016

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Mapping disease transmission risk is crucial in public and animal health for evidence based decision-making. Ecology and epidemiology are highly related disciplines that may contribute to improvements in mapping disease, which can be used to answer health related questions. Ecological niche modeling is increasingly used for understanding the biogeography of diseases in plants, animals, and humans. However, epidemiological applications of niche modeling approaches for disease mapping can fail to generate robust study designs, producing incomplete or incorrect inferences. This manuscript is an overview of the history and conceptual bases behind ecological niche modeling, specifically as applied to epidemiology and public health; it does not pretend to be an exhaustive and detailed description of ecological niche modeling literature and methods. Instead, this review includes selected state-of-the-science approaches and tools, providing a short guide to designing studies incorporating information on the type and quality of the input data (i.e., occurrences and environmental variables), identification and justification of the extent of the study area, and encourages users to explore and test diverse algorithms for more informed conclusions. We provide a friendly introduction to the field of disease biogeography presenting an updated guide for researchers looking to use ecological niche modeling for disease mapping. We anticipate that ecological niche modeling will soon be a critical tool for epidemiologists aiming to map disease transmission risk, forecast disease distribution under climate change scenarios, and identify landscape factors triggering outbreaks.

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“…These include efficient long-range transport in neurons, low cytotoxicity, and high-level gene expression (Mebatsion et al, 1996b; Wickersham et al, 2007a; Dietzschold et al, 2008). Wild-type RABV has a broad host species range that includes almost all terrestrial mammals, bats, and birds (Gough and Jorgenson, 1976; Nel and Markotter, 2007), and this likely extends to all RABV derived vectors making them suitable for use in a range of animal model systems. The RABV genome (Conzelmann et al, 1990) is small, modular, and readily accepts foreign genes without the issues of instability inherent to other RNA viruses (Mebatsion et al, 1996b; Conzelmann, 1998).…”

Section: Trans-synaptic Tracers For the Study Of Neural Circuit Connementioning

confidence: 99%

Revealing the secrets of neuronal circuits with recombinant rabies virus technology

Ginger¹,

Haberl²,

Conzelmann³

et al. 2013

Front. Neural Circuits

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An understanding of how the brain processes information requires knowledge of the architecture of its underlying neuronal circuits, as well as insights into the relationship between architecture and physiological function. A range of sophisticated tools is needed to acquire this knowledge, and recombinant rabies virus (RABV) is becoming an increasingly important part of this essential toolbox. RABV has been recognized for years for its properties as a synapse-specific trans-neuronal tracer. A novel genetically modified variant now enables the investigation of specific monosynaptic connections. This technology, in combination with other genetic, physiological, optical, and computational tools, has enormous potential for the visualization of neuronal circuits, and for monitoring and manipulating their activity. Here we will summarize the latest developments in this fast moving field and provide a perspective for the use of this technology for the dissection of neuronal circuit structure and function in the normal and diseased brain.

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Rabies Antibodies in Sera of Wild Birds

Cited by 17 publications

References 1 publication

Chicken Interferon-Inducible Transmembrane Protein 3 Restricts Influenza Viruses and Lyssaviruses In Vitro

Chicken Interferon-Inducible Transmembrane Protein 3 Restricts Influenza Viruses and Lyssaviruses In Vitro

Advances and Limitations of Disease Biogeography Using Ecological Niche Modeling

Revealing the secrets of neuronal circuits with recombinant rabies virus technology

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