RabGAPs in skeletal muscle function and exercise

Espelage, Lena; Al-Hasani, Hadi; Chadt, Alexandra

doi:10.1530/jme-19-0143

Cited by 25 publications

(20 citation statements)

References 122 publications

(183 reference statements)

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“…Both insulin- and contraction-stimulated translocations are additive, and it has been proposed that both stimuli utilize distinct intracellular GLUT4 storage pools [ 59 ]. Several signaling pathways have been implicated to play roles in regulating GLUT4 translocation in response to insulin and contraction [ 62 , 100 , 118 , 187 ].…”

Section: Skeletal Muscle and Adipose Tissuementioning

confidence: 99%

“…TBC1D1 is phosphorylated by AKT at Ser 231 and Thr 590 , whereas TBC1D4 has at least six phosphorylation motifs for AKT [ 139 ]. In response to muscle contraction, AMPK has been described to phosphorylate at least 5 to 7 sites in TBC1D1 and TBC1D4, respectively [ 62 ]. Current research investigates the contribution of the individual phosphorylation sites in the RabGAPs and their possible interactions with effectors.…”

Section: Skeletal Muscle and Adipose Tissuementioning

confidence: 99%

See 1 more Smart Citation

Glucose transporters in adipose tissue, liver, and skeletal muscle in metabolic health and disease

Chadt

Al-Hasani

2020

Pflugers Arch - Eur J Physiol

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265

192

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A family of facilitative glucose transporters (GLUTs) is involved in regulating tissue-specific glucose uptake and metabolism in the liver, skeletal muscle, and adipose tissue to ensure homeostatic control of blood glucose levels. Reduced glucose transport activity results in aberrant use of energy substrates and is associated with insulin resistance and type 2 diabetes. It is well established that GLUT2, the main regulator of hepatic hexose flux, and GLUT4, the workhorse in insulin-and contraction-stimulated glucose uptake in skeletal muscle, are critical contributors in the control of whole-body glycemia. However, the molecular mechanism how insulin controls glucose transport across membranes and its relation to impaired glycemic control in type 2 diabetes remains not sufficiently understood. An array of circulating metabolites and hormone-like molecules and potential supplementary glucose transporters play roles in fine-tuning glucose flux between the different organs in response to an altered energy demand.

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Section: Skeletal Muscle and Adipose Tissuementioning

confidence: 99%

Section: Skeletal Muscle and Adipose Tissuementioning

confidence: 99%

Glucose transporters in adipose tissue, liver, and skeletal muscle in metabolic health and disease

Chadt

Al-Hasani

2020

Pflugers Arch - Eur J Physiol

Self Cite

265

192

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“…A cascade of linked Rab GAPs and Rabs is also likely [172]. TBC1D1 and TBC1D4 are also targets of AMPK and there may be some convergence with signalling from insulin activation of Akt [71,103]. However, it has yet to be demonstrated that GLUT4 exocytosis occurs in response to AMPK signalling to the Rab GAPS.…”

Section: Glut4mentioning

confidence: 99%

“…This is evident from experiments in which metformin, hypoxia, oligomycin and DNP treatments have been studied [4,165,229,230]. Exercise and insulin action impinge on GLUT4 traffic through different mechanisms [71,173]. These effects may be partly related to changes in the AMP/ATP level and activation of AMPK [4,113,121,125].…”

Section: Glut4mentioning

confidence: 99%

Structure, function and regulation of mammalian glucose transporters of the SLC2 family

Holman

2020

Pflugers Arch - Eur J Physiol

114

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The SLC2 genes code for a family of GLUT proteins that are part of the major facilitator superfamily (MFS) of membrane transporters. Crystal structures have recently revealed how the unique protein fold of these proteins enables the catalysis of transport. The proteins have 12 transmembrane spans built from a replicated trimer substructure. This enables 4 trimer substructures to move relative to each other, and thereby alternately opening and closing a cleft to either the internal or the external side of the membrane. The physiological substrate for the GLUTs is usually a hexose but substrates for GLUTs can include urate, dehydro-ascorbate and myo-inositol. The GLUT proteins have varied physiological functions that are related to their principal substrates, the cell type in which the GLUTs are expressed and the extent to which the proteins are associated with subcellular compartments. Some of the GLUT proteins translocate between subcellular compartments and this facilitates the control of their function over long-and shorttime scales. The control of GLUT function is necessary for a regulated supply of metabolites (mainly glucose) to tissues. Pathophysiological abnormalities in GLUT proteins are responsible for, or associated with, clinical problems including type 2 diabetes and cancer and a range of tissue disorders, related to tissue-specific GLUT protein profiles. The availability of GLUT crystal structures has facilitated the search for inhibitors and substrates and that are specific for each GLUT and that can be used therapeutically. Recent studies are starting to unravel the drug targetable properties of each of the GLUT proteins.

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“…The KLF3 gene is an essential member of the KLF family and is involved in the regulation of growth, development of muscle and adipose tissue in cattle 53 and goats 54 . The TBC1D1 gene corresponds to a critical signaling factor of skeletal muscle substrate utilization 55 and was correlated with improved muscle mass (chicken 56 , porcine 57 and rabbits 58 ). Additionally, these findings account for the possible polygenic nature of the growth trait 59 , i.e., the growth of fish is controlled by large numbers of small-effect genes 60 .…”

Section: Signatures Of Selectionmentioning

confidence: 99%

Whole genome re-sequencing reveals recent signatures of selection in three strains of farmed Nile tilapia (Oreochromis niloticus)

Cádiz

López

Díaz-Domínguez

et al. 2020

Sci Rep

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Nile tilapia belongs to the second most cultivated group of fish in the world, mainly because of its favorable characteristics for production. Genetic improvement programs and domestication process of Nile tilapia may have modified the genome through selective pressure, leaving signals that can be detected at the molecular level. In this work, signatures of selection were identified using genomewide SNP data, by two haplotype-based (iHS and Rsb) and one F ST based method. Whole-genome re-sequencing of 326 individuals from three strains (A, B and C) of farmed tilapia maintained in Brazil and Costa Rica was carried out using Illumina HiSeq 2500 technology. After applying conventional SNP-calling and quality-control filters, ~ 1.3 M high-quality SNPs were inferred and used as input for the iHS, Rsb and F ST based methods. We detected several candidate genes putatively subjected to selection in each strain. A considerable number of these genes are associated with growth (e.g. NCAPG, KLF3, TBC1D1, TTN), early development (e.g. FGFR3, PFKFB3), and immunity traits (e.g. NLRC3, PIGR, MAP1S). These candidate genes represent putative genomic landmarks that could be associated to traits of biological and commercial interest in farmed nile tilapia. Nile tilapia (Oreochromis niloticus) is a teleost fish of the Cichlidae family native to Africa and the Middle East. The geographic range of the species extends from 8°N to 32°N 1. The first record of domestication is dated around 3,500 years ago as evidenced in paintings at the Theban tombs in Egypt 2. Nowadays, this species is the second most cultivated group of fish in the world 3. Favorable characteristics for production include rapid growth, adaptability to different culture conditions, tolerance to high densities, disease resistance, easy reproduction, and tolerance to low concentrations of oxygen 4. Genetic improvement programs (GIPs) for Nile tilapia began in 1988 as an approach to counteract the production decrease generated by introgressions with Mozambique tilapia (Oreochromis mossambicus) 5,6. Since then, nearly twenty GIPs have been established for Nile tilapia around the world 7,8. GIPs aim to improve traits of commercial interest, such as growth rate, disease resistance, cold and salinity tolerance 7. The GIFT (Genetic Improvement of Farmed Tilapia) 9 Nile tilapia strain was developed by the ICLARM (International Centre for Living Aquatic Resources Management, now the WorldFish Center), in collaboration with the Norwegian Institute of Aquaculture Research (AKVAFORSK, now NOFIMA Marin) 1. The implementation of GIPs for the GIFT population has been successful, because growth rate in Nile tilapia has doubled in five generations, showing that this species had a positive response to selection 1 .

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RabGAPs in skeletal muscle function and exercise

Cited by 25 publications

References 122 publications

Glucose transporters in adipose tissue, liver, and skeletal muscle in metabolic health and disease

Glucose transporters in adipose tissue, liver, and skeletal muscle in metabolic health and disease

Structure, function and regulation of mammalian glucose transporters of the SLC2 family

Whole genome re-sequencing reveals recent signatures of selection in three strains of farmed Nile tilapia (Oreochromis niloticus)

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