Rabeprazole versus ranitidine for the treatment of erosive gastroesophageal reflux disease: A double-blind, randomized clinical trial

Abstract

Rabeprazole was superior to ranitidine in esophageal healing and symptom relief in patients with erosive gastroesophageal reflux disease, and was equally well tolerated.

Acid suppression in gastro-oesophageal reflux disease: Why? How? How much and when?

“…A recent study evaluating rabeprazole 20 mg daily and ranitidine 150 mg four times a day showed that after eight weeks, both regimens provided reasonable healing of oesophagitis (92% for rabeprazole and 71% for ranitidine), but the percentage of symptom-free patients was less (50% for rabeprazole and 28% for ranitidine). 11 Similar results have been obtained in studies using various doses of omeprazole. After four weeks, oesophagitis healing rates were 76% for omeprazole 20 mg every day and 56% for omeprazole 10 mg every day.…”

Effect of omeprazole 10 mg on intragastric pH in three different CYP2C19 genotypes, compared with omeprazole 20 mg and lafutidine 20 mg, a new H2‐receptor antagonist

“…Thus, comparative studies have demonstrated that protonpump inhibitors provided far superior GERD healing compared with histamine H 2 -receptor antagonists (H 2 -RAs). [1][2][3][4][5][6][7][8][9][10][11] In Japan, omeprazole 10 mg, as well as 20 mg, is widely used as maintenance therapy for GERD. Hallerback et al reported that maintenance therapy with omeprazole 10 mg was superior to ranitidine 300 mg 5 .…”

Randomized, Comparative Study of Standard Dose of Rabeprazole versus Omeprazole in Gerd/Heartburn Symptom Relief

“…The most effective drugs in treatment of GERD are proton pump inhibitors which produce more complete remission of heartburn symptoms than H2 receptor antagonists or prokinetic agents [8,10]. They are also more effective than H2 receptor antagonists in promoting healing of oesophageal lesions [8]. In many of the current practice guidelines Proton pump inhibitors are recommended as reasonable for initial treatment for GERD [9].…”

“…When treating GERD, the goal of treatment should include not only the healing of mucosal lesions, but also the relief of heartburn symptoms [8][9]. The most effective drugs in treatment of GERD are proton pump inhibitors which produce more complete remission of heartburn symptoms than H2 receptor antagonists or prokinetic agents [8,10].…”