Rabeprazole Is Effective in Treating Laryngopharyngeal Reflux in a Randomized Placebo-Controlled Trial

Lam, P.; Ng, Manwa L.; Cheung, Ting Kin; Wong, Birgitta Yee-Hang; Tan, Victoria P.; Fong, Daniel Yee Tak; Wei, William I.; Wong, Benjamin C Y

doi:10.1016/j.cgh.2010.03.009

Cited by 78 publications

(83 citation statements)

References 24 publications

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“…Similarly, Shaheen et al [41] reported no symptom improvement difference between high-dose esomeprazole versus placebo in patients with chronic cough and no concomitant baseline heartburn. However, Lam et al [42], in a study of 24 patients with LPR, showed that 12 weeks of treatment with rabeprazole was superior to placebo for symptom improvement. In this study, the authors used RSI and RFS as objective criteria for symptom and laryngeal sign measurements.…”

Section: Therapymentioning

confidence: 96%

Evaluation of Patients with Suspected Laryngopharyngeal Reflux: A Practical Approach

Abou-Ismail

Vaezi

2011

Curr Gastroenterol Rep

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Laryngopharyngeal reflux (LPR) is associated with symptoms of laryngeal irritation such as throat pain, cough, and voice change. Currently, the two main diagnostic tools are laryngoscopy and reflux monitoring. On laryngoscopy, the signs most commonly used to diagnose LPR are erythema and edema of the larynx; however, these signs are not specific for LPR, may be associated with other causes, and may even be found in healthy individuals. In addition, pH testing has low sensitivity in diagnosing gastroesophageal reflux disease-related laryngeal findings. Proton pump inhibitor (PPI) therapy remains the cornerstone of treatment. The current management recommendation for this group of patients is empiric therapy with twice-daily PPIs for 1 to 2 months. In the majority of those who are unresponsive to such therapy, other causes of laryngeal irritation are considered. Surgical fundoplication is most effective in those who are responsive to acid-suppressive therapy.

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Section: Therapymentioning

confidence: 96%

Evaluation of Patients with Suspected Laryngopharyngeal Reflux: A Practical Approach

Abou-Ismail

Vaezi

2011

Curr Gastroenterol Rep

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“…Several randomized controlled trials (RCTs) have been performed to investigate the treatment efficacy of PPI therapy for LPR. [7][8][9][10] However, most of these RCTs had a relatively small sample size and no unified criteria in the monitoring of the treatment response. In 2006, Qadeer et al 11 performed a meta-analysis of RCTs to investigate this issue and found that PPI therapy could not offer significant clinical benefit over placebo in patients with GERD-related LPR.…”

mentioning

confidence: 98%

Proton Pump Inhibitor Therapy for the Treatment of Laryngopharyngeal Reflux

Guo

Wang

2016

Journal of Clinical Gastroenterology

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“…Reichel and colleagues [Reichel et al 2008] reported a randomized, double-blind, placebo-controlled trial with esomeprazole 20 mg twice daily for 3 months in patients with symptoms and endoscopic signs of LPR, which found significant improvement in both symptoms and laryngeal examination. Likewise, Lam and colleagues [Lam et al 2010] performed a prospective, randomized, double-blind, placebo-controlled study with rabeprazole 20 mg twice daily for 3 months in patients with symptoms and endoscopic signs of LPR, resulting in a significant improvement of symptoms, but not laryngeal findings. However, on the basis of a closer examination of these two studies, Vaezi [Vaezi, 2010] argued that the real significant improvement was for heartburn symptoms and not for chronic throat symptoms.…”

Section: Medical Therapymentioning

confidence: 99%

Optimal treatment of laryngopharyngeal reflux disease

Martinucci

Bortoli

Savarino

et al. 2013

Therapeutic Advances in Chronic Disease

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Laryngopharyngeal reflux is defined as the reflux of gastric content into larynx and pharynx. A large number of data suggest the growing prevalence of laryngopharyngeal symptoms in patients with gastroesophageal reflux disease. However, laryngopharyngeal reflux is a multifactorial syndrome and gastroesophageal reflux disease is not the only cause involved in its pathogenesis. Current critical issues in diagnosing laryngopharyngeal reflux are many nonspecific laryngeal symptoms and signs, and poor sensitivity and specificity of all currently available diagnostic tests. Although it is a pragmatic clinical strategy to start with empiric trials of proton pump inhibitors, many patients with suspected laryngopharyngeal reflux have persistent symptoms despite maximal acid suppression therapy. Overall, there are scant conflicting results to assess the effect of reflux treatments (including dietary and lifestyle modification, medical treatment, antireflux surgery) on laryngopharyngeal reflux. The present review is aimed at critically discussing the current treatment options in patients with laryngopharyngeal reflux, and provides a perspective on the development of new therapies.

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Rabeprazole Is Effective in Treating Laryngopharyngeal Reflux in a Randomized Placebo-Controlled Trial

Cited by 78 publications

References 24 publications

Evaluation of Patients with Suspected Laryngopharyngeal Reflux: A Practical Approach

Evaluation of Patients with Suspected Laryngopharyngeal Reflux: A Practical Approach

Proton Pump Inhibitor Therapy for the Treatment of Laryngopharyngeal Reflux

Optimal treatment of laryngopharyngeal reflux disease

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