Rabbits with naturally occurring cataracts referred for phacoemulsification and intraocular lens implantation: a preliminary study of 12 cases

Sanchez, Rick F.; Everson, Richard; Hedley, Joanna; Dawson, Charlotte; Lam, Richard; Priestnall, Simon L.; Carellan, Alejandra Garcia de; Miguel, Cristina de; Seymour, Christopher W.

doi:10.1111/vop.12525

Cited by 18 publications

(8 citation statements)

References 56 publications

(76 reference statements)

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“…Comment s : Lens fiber degeneration is a microscopic finding that is usually correlated with ophthalmic examination findings of lens opacity. Spontaneous lens opacities can occur at different ages in rabbits and can exhibit breed or strain specificity 24 , 313 , 314 , 315 , 316 , 317 . Congenital lenticular opacities of uncertain etiology have been reported in neonates, but most spontaneous cataracts occur in adult or even aged animals 222 .…”

Section: Section 16: Special Sensesmentioning

confidence: 99%

International Harmonization of Nomenclature and Diagnostic Criteria (INHAND): Nonproliferative and Proliferative Lesions of the Rabbit

et al. 2021

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The INHAND (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions Project (www.toxpath.org/inhand. asp) is a joint initiative of the Societies of Toxicologic Pathology from Europe (ESTP), Great Britain (BSTP), Japan (JSTP) and North America (STP) to develop an internationally accepted nomenclature for proliferative and non-proliferative lesions in laboratory animals. The purpose of this publication is to provide a standardized nomenclature for classifying microscopic lesions observed in most tissues and organs from the laboratory rabbit used in nonclinical safety studies. Some of the lesions are illustrated by color photomicrographs. The standardized nomenclature presented in this document is also available electronically on the internet (http://www.goreni.org/). Sources of material included histopathology databases from government, academia, and industrial laboratories throughout the world. Content includes spontaneous lesions as well as lesions induced by exposure to test materials. Relevant infectious and parasitic lesions are included as well. A widely accepted and utilized international harmonization of nomenclature for lesions in laboratory animals will provide a common language among regulatory and scientific research organizations in different countries and increase and enrich international exchanges of information among toxicologists and pathologists.

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Section: Section 16: Special Sensesmentioning

confidence: 99%

International Harmonization of Nomenclature and Diagnostic Criteria (INHAND): Nonproliferative and Proliferative Lesions of the Rabbit

et al. 2021

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“…Iris inflammation occurred in both groups, coinciding with the higher frequencies of corneal opacity and aqueous flare. The appearance of signs of inflammation of the anterior segment is common after PHACO, possibly due to the manipulation of instruments, contact of the phacoemulsifier probe tip with eye structures or iris prolapse (20,27) .…”

Section: Discussionmentioning

confidence: 99%

Intracameral tenecteplase during phacoemulsification in rabbits: clinical assessment of the anterior segment and biochemical analysis of the aqueous humor

et al. 2020

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To evaluate the use of tenecteplase in transoperative phacoemulsification in healthy rabbits, the study was carried out with fifteen New Zealand rabbits, divided into three groups: control group (CG), untreated group (UG) and treated group (TG). UG and TG were operated by phacoemulsification and TG received 50 µg / 0.3 mL of intracameral tenecteplase. The postoperative evaluations were 24 h, 72 h, 7 days, 15 days and 21 days. In TP21 the animals were submitted to euthanasia and aqueous humor samples were collected. No significant differences were observed in the clinical evaluations between CG and TG in relation to incidence rates of intraocular pressure (IOP), corneal edema, fibrin deposits, hyphema, aqueous flare and synechia. In the physicochemical evaluation of the aqueous humor, there were no significant differences between the three groups in relation to pH values and concentrations of chloride ions. The aqueous humor density values were statistically different between CG and the other groups. In the histological evaluation, there were no significant differences between the groups. The use of tenecteplase in transoperative phacoemulsification in rabbits did not present significant differences in terms of clinical, physicochemical and histological parameters.

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“…The preferred treatment for cataracts is surgical extraction via phacoemulsiication (Fig 13); hypopyon and iridal granulomas may be aspirated concurrently. Recently, Sanchez and others (2018) reported good long-term results following phacoemulsiication in a group of rabbits. Medical treatment comprises topical and systemic anti-inlammatories, in addition to systemic anti-parasiticides; for example, fenbendazole 20 mg/kg once daily for 28 days (Panacur Rabbit; Intervet).…”

Section: Lenticular Disease Cataractsmentioning

confidence: 99%

Guide to ophthalmology in rabbits

Maini¹,

Hartley²

2019

In Practice

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Rabbits with naturally occurring cataracts referred for phacoemulsification and intraocular lens implantation: a preliminary study of 12 cases

Abstract: Phacoemulsification with CTR and IOL implantation offers good long-term results and can improve the quality of life of pet rabbits. Retinal detachment, lens luxation, expulsive choroidal hemorrhage, and anesthetic death are potential complications.

Cited by 18 publications

References 56 publications

International Harmonization of Nomenclature and Diagnostic Criteria (INHAND): Nonproliferative and Proliferative Lesions of the Rabbit

International Harmonization of Nomenclature and Diagnostic Criteria (INHAND): Nonproliferative and Proliferative Lesions of the Rabbit

Intracameral tenecteplase during phacoemulsification in rabbits: clinical assessment of the anterior segment and biochemical analysis of the aqueous humor

Guide to ophthalmology in rabbits

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