Rabbiteye blueberry prevents osteoporosis in ovariectomized rats

Li, Tao; Wu, Shou-Mian; Xu, Zhiyuan; Ouyang, Sheng

doi:10.1186/s13018-014-0056-9

Cited by 22 publications

(25 citation statements)

References 33 publications

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“…We speculate that the beneficial antioxidant effect of BBs is mainly due to the polyphenolic fraction; in fact, dietary antioxidant polyphenols activate osteoblast function promoting bone growth and inhibiting osteoclast differentiation [1][2][3][4][5]31,32]. Literature data show that ROS might be involved in the pathogenesis of bone loss and that nutritional approaches to antioxidant strategies may prevent this [2,6,12,14].…”

Section: Discussionmentioning

confidence: 98%

Blueberry juice protects osteocytes and bone precursor cells against oxidative stress partly through SIRT1

et al. 2019

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Oxidative stress and abnormal osteocyte apoptosis are often related to dysregulation of bone turnover and chronic bone loss, and so fruit and vegetables with high antioxidant potential may play an important role in the prevention and/or management of osteoporosis. Osteocytes are the main regulators of bone remodelling. For the first time, we demonstrate here that blueberry juice ( BJ ), obtained from Vaccinium myrtillus , rich in polyphenols, shows antioxidant and antiosteoclastogenic properties in MLO ‐Y4 osteocytes. We report that BJ prevents oxidative stress‐induced apoptosis and reverses the increase in receptor activator of nuclear factor κB ligand and sclerostin expression, crucial factors for osteoclast activation and bone resorption. BJ is also able to prevent oxidative stress‐induced cell cytotoxicity in bone marrow mesenchymal stromal cells ( MSC s), which are considered to be an important tool for cell therapy in bone disorders. No significant difference in preventing these events was observed between BJ and blueberry dry extract containing equal amounts of total soluble polyphenols. We have also shown that blueberry acts as both an antioxidant and an activator of sirtuin type 1, a class III histone deacetylase involved in cell death regulation and considered a molecular target for blocking bone resorption without affecting osteoclast survival. Overall, these novel data obtained in osteocytes and MSC s may help us clarify the mechanisms by which blueberry counteracts oxidative stress‐induced damage in bone remodelling and osteogenesis at the cellular and molecular level. Our findings are consistent with the reported beneficial effects of blueberry on bone tissue reported in animal studies, which suggest that blueberry may be a useful supplement for the prevention and/or management of osteoporosis and osteogenic process.

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Section: Discussionmentioning

confidence: 98%

Blueberry juice protects osteocytes and bone precursor cells against oxidative stress partly through SIRT1

et al. 2019

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“…Moreover, even if BB polyphenols undergo complex metabolic modifications, their derivatives have the same functional characteristics [34,36]. The flavonoids and anthocyanins present in BB have strong antioxidant capacity [24,31,32,54], and these, along with the other polyphenol compounds and their derivatives, favor the formation of bone mass [18][19][20]30,54].…”

Section: Discussionmentioning

confidence: 99%

“…Literature data obtained in animals or cell lines showed the antioxidant activity of various natural substances [1]. In particular, diets rich in vegetables and/or fruits with high content of active antioxidants, such as polyphenols including flavonols, isoflavones, and phytosterols/phytoestrogens, can have an important role in prevention and/or management of osteoporosis and bone inflammatory diseases related to oxidative stress [17][18][19][20][21]. Indeed, plasma antioxidant content was found diminished in osteoporotic women [11,22].…”

Section: Introductionmentioning

confidence: 99%

“…For this, osteoporosis is considered a highly debilitating and socially relevant pathology; in fact, among the elderly, the pathological consequences of osteoporosis are among the main causes of mortality [28,29]. Recently, it was shown that diets containing blueberry (BB) prevent osteoporosis in ovariectomized rats [19,26,30]; indeed, BB and, in particular, Vaccinuim myrtillus (VM) have a wide variety and high concentrations of well-characterized polyphenols such as anthocyanins, coumarins, flavonols, flavanols, and their phenolic derivatives [31,32], with beneficial properties in bone anabolism [17][18][19][20][21]. Moreover, recent studies suggest VM as a "functional food" and, as such, of benefit for dietary supplementation [31,32]; today, VM, together with Vaccinium corymbosum, is among the main species of BB used in the food industry.…”

Section: Introductionmentioning

confidence: 99%

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Blueberry Juice Antioxidants Protect Osteogenic Activity against Oxidative Stress and Improve Long-Term Activation of the Mineralization Process in Human Osteoblast-Like SaOS-2 Cells: Involvement of SIRT1

et al. 2020

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Diets rich in fruits and vegetables with many antioxidants can be very important in the prevention and treatment of osteoporosis. Studies show that oxidative stress, often due to lack of antioxidants, is involved in alteration of bone remodeling and reduction in bone density. This study demonstrates in human osteoblast-like SaOS-2 cells that blueberry juice (BJ), containing 7.5 or 15 μg∙mL−1 total soluble polyphenols (TSP), is able to prevent the inhibition of osteogenic differentiation and the mineralization process due to oxidative stress induced by glutathione depletion. This situation mimics a metabolic condition of oxidative stress that may occur during estrogen deficiency. The effect of BJ phytochemicals occurs through redox- and non-redox-regulated mechanisms. BJ protects from oxidative damage factors related to bone remodeling and bone formation, such as alkaline phosphatase and Runt-related transcription factor 2. It upregulates these factors by activation of sirtuin type 1 deacetylase expression, a possible molecular target for anti-osteoporotic drugs. Quantitative analysis of TSP in BJ shows high levels of anthocyanins with high antioxidant capacity and bioavailability. These novel data may be important to elucidate the molecular and cellular beneficial effects of blueberry polyphenols on bone regeneration, and they suggest their use as a dietary supplement for osteoporosis prevention and therapies.

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“…Além de ser amplamente utilizado na composição de bolos, tortas e geleias, a partir dos anos 2000 o mirtilo se tornou objeto de diversos estudos relacionados à sua atividade nutracêutica que, pelo alto teor de antocianinas, teve seu consumo associado ao combate do câncer , da osteoporose (LI et al, 2014), contra problemas vasculares (BASU et al, 2010), à atividade anti-inflamatória (MCLEAY et al, 2012), à doenças como o Alzheimer , contra a degeneração macular, além de favorecer a visão noturna Na Europa, estima-se que a produção tenha atingindo aproximadamente 65 mil toneladas no ano de 2016, com a Polônia e Alemanha sendo responsáveis pelas maiores produções, de 14.721 e 10.710 toneladas, respectivamente . No ano de 2014, destaque para as produções crescentes da China, de 20 mil toneladas e da África do Sul, que correspondeu a 2 mil toneladas do fruto (BRAZELTON, 2016).…”

Section: Panorama Da Produção De Mirtilosunclassified

Fisiologia de mirtileiros de baixa exigência em frio, cultivados em região subtropical

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Rabbiteye blueberry prevents osteoporosis in ovariectomized rats

Cited by 22 publications

References 33 publications

Blueberry juice protects osteocytes and bone precursor cells against oxidative stress partly through SIRT1

Blueberry juice protects osteocytes and bone precursor cells against oxidative stress partly through SIRT1

Blueberry Juice Antioxidants Protect Osteogenic Activity against Oxidative Stress and Improve Long-Term Activation of the Mineralization Process in Human Osteoblast-Like SaOS-2 Cells: Involvement of SIRT1

Fisiologia de mirtileiros de baixa exigência em frio, cultivados em região subtropical

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