Rabbit Neoplasia

Tinkey, Peggy T.; Uthamanthil, Rajesh; Weisbroth, Steven H.

doi:10.1016/b978-0-12-380920-9.00016-x

Cited by 14 publications

(17 citation statements)

References 303 publications

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“…In the scientific literature, there are only 4 reports of spontaneous primary lung tumors in rabbits, all malignant. 3,11,39,41,43,48 Primary lung tumors present in this series were small, benign, and incidental and therefore potentially easily missed during routine necropsy. Although Shope papillomavirus (kappapapillomavirus-2) is used in this institution, only a single rabbit in this study was exposed to that agent and the rabbit did not develop a lung tumor.…”

Section: Discussionmentioning

confidence: 93%

Spontaneous Lung Lesions in Aging Laboratory Rabbits (Oryctolagus cuniculus)

et al. 2016

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Spontaneous age-related lesions of laboratory rabbits are not well documented in the contemporary scientific literature. A retrospective study of diagnostic necropsies of 36 rabbits >2 years of age found a number of common lung lesions. Fibromuscular intimal hyperplasia affected medium and to a lesser extent large pulmonary arteries and was present to a variable extent in all 36 rabbits >2 years of age. The lesions were characterized by fragmentation and/or reduplication of the internal elastic lamina (IEL), proliferation of smoothelinþ/alpha-smooth muscle actin (a-SMA)þ/vimentinÀ smooth muscle cells and fewer smoothelinÀ/a-SMAþ/vimentinþ myofibroblasts, and intimal deposition of collagen without thrombosis, embolism, or evidence of pulmonary hypertension. Pulmonary emphysema, present in 30/36 rabbits, was characterized by the loss of alveolar septa; most affected rabbits did not have clinical signs of respiratory disease. In 8/13 rabbits of the inbred EIII/JC audiogenic strain, we identified a unique syndrome of granulomatous pneumonia containing hyaline brown to gray, globular to ring-like acellular material that was Alcian blue and periodic acid-Schiff positive. The material was immunoreactive for surfactant protein-A and had the ultrastructural appearance of multilamellar vesicles, suggesting a genetic defect in surfactant metabolism. Additionally, we found small benign primary lung tumors (fibropapillomas, 5 rabbits) not previously described. Other findings included heterotopic bone (5 rabbits), subacute to chronic suppurative bronchopneumonia, pyogranulomatous pneumonia with plant material, and pulmonary artifacts from barbiturate euthanasia solution.Although spontaneous background lesions of aging laboratory mice and rats are well documented and described, 7,9,19,23,31 there is less information on spontaneous lesions of aging laboratory rabbits. 14,15,21 In part this is because of the types of acute or relatively short-term studies for which rabbits are commonly used. In some cases where age-related lesions are described, such as spontaneous pulmonary emphysema, 42 other more recent references are contradictory, based apparently on the lack of additional confirmatory reporting. 4,8 Other spontaneous age-related lesions, such as unique intimal proliferations in the pulmonary arteries, are poorly documented in the English language literature, 20 and can resemble iatrogenic lesions caused by experimental manipulation. 27 While most rabbits used in research are outbred New Zealand White (NZW) or Dutch-belted stock, inbred rabbits strains do exist, including the audiogenic (EIII/JC) strain. The inbred III/J parent rabbit strain was originally developed at the Jackson Laboratory in 1932 by Dr Paul B. Sawin using NZW rabbits from Dr William Ernest Castle. The audiogenic (EIII/J) substrain was selected for a predisposition to sound-induced seizures by Dr Richard R. Fox in 1961. 13 The strain came to Penn State Hershey in 1988 from the National Cancer Institute. 37 Rabbits have been used as an induced experimental...

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Section: Discussionmentioning

confidence: 93%

Spontaneous Lung Lesions in Aging Laboratory Rabbits (Oryctolagus cuniculus)

et al. 2016

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“…Despite their use as laboratory models for intraocular neoplasia in humans, naturally occurring intraocular neoplasia seems to be quite rare in this species. Some sources state that the eye is a common site for lymphoma in rabbits, but there are no published studies describing the prevalence of ocular lymphoma in this species. There is one report of a naturally occurring melanoma in a very young laboratory rabbit; this rabbit had been recently inoculated with a virulent strain of Treponema pallidum, and the authors suggested that this may have contributed to the development of the tumor .…”

Section: Discussionmentioning

confidence: 99%

“…While domestic rabbits ( Oryctolagus cuniculus ) are commonly used as experimental models for ocular neoplasia, there is very limited information available about naturally occurring ocular neoplasms in this species. This study reviews a series of cases of iridociliary tumors in rabbits, describing clinical presentation and progression, histopathologic characteristics, and (when available) follow‐up after surgical removal.…”

Section: Introductionmentioning

confidence: 99%

Four cases of iridociliary tumors in domestic rabbits (Oryctolagus Cuniculus)

Swisher

Klein²,

Lennox

et al. 2018

Veterinary Ophthalmology

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Spontaneously occurring ocular neoplasia is rarely reported in rabbits. This case series presents four cases of rabbits diagnosed with iridociliary tumors, which have not been previously reported in this species. Major pathological findings include epithelial tumors affecting the anterior uvea with variable pigmentation and basement membrane formation. Follow-up information was only available for two cases, but neither showed evidence of metastasis, suggesting that the prognosis for these tumors in rabbits, as in other species, may be very good.

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“…Endometrial adenocarcinoma is the most common tumor in aged female rabbits, with an incidence of 79% reported in a colony of 5-year-old rabbits (Baba and Von Haam, 1972). Neoplasia in Sylvilagus and Lepus were also discussed (Tinkey et al, 2012). This review contained data on case reports, descriptions of biologic aspects of naturally occurring tumors and reports of experimentally induced tumor models.…”

Section: H Neoplasiamentioning

confidence: 99%