Rabbit hemorrhagic disease

Belz, Katie

doi:10.1053/j.saep.2004.01.006

Cited by 8 publications

(3 citation statements)

References 7 publications

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“…Rabbit hemorrhagic disease virus (RHDV) is a species of calicivirus affecting wild and domestic European rabbits ( Oryctolagus cuniculus ) that causes acute hepatic necrosis, disseminated intravascular coagulopathy and rapid demise ( Belz, 2004 ). RHDV is a positive sense, single stranded RNA spread by airborne and fecal-oral transmission.…”

Section: Survey Methodologymentioning

confidence: 99%

“…Among the most widely used are acetaminophen (APAP), d-galactosamine (d-Gal), and carbon tetrachloride (CCl 4 ) ( Apte, 2014 ; Frank et al, 2020 ; Mossanen & Tacke, 2015 ) ( Table 2 ). Immunogenic models refer to models of viral hepatitis, as well as means of inducing hepatitis by activating cell death pathways, such as with anti-Fas antibodies ( Bajt et al, 2000 ; Belz, 2004 ). There are additional models for specific etiologies of ALF that fall outside of these categories, such as the Long Evans Cinnamon rat, which models ALF in the context of abnormal copper metabolism, similar to Wilson’s disease seen in humans ( Siaj et al, 2012 ).…”

Section: Introductionmentioning

confidence: 99%

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Preclinical models of acute liver failure: a comprehensive review

Hefler

Marfil‐Garza

Pawlick

et al. 2021

PeerJ

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Acute liver failure is marked by the rapid deterioration of liver function in a previously well patient over period of days to weeks. Though relatively rare, it is associated with high morbidity and mortality. This makes it a challenging disease to study clinically, necessitating reliance on preclinical models as means to explore pathophysiology and novel therapies. Preclinical models of acute liver failure are artificial by nature, and generally fall into one of three categories: surgical, pharmacologic or immunogenic. This article reviews preclinical models of acute liver failure and considers their relevance in modeling clinical disease.

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Section: Survey Methodologymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Preclinical models of acute liver failure: a comprehensive review

Hefler

Marfil‐Garza

Pawlick

et al. 2021

PeerJ

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“…The severity of clinical symptoms depends on the animals breed, age, immunity, geographical distribution, infecting virus dose, and infection methods. In the pre-acute stage, healthy animals abruptly die within 12 to 36 hours after the onset of the disease without showing any preceding clinical signs (Belz 2004;Calvete et al 2018;Ahmed et al 2022).…”

Section: Introductionmentioning

confidence: 99%

Epidemiology of Rabbit Hemorrhagic Disease Virus in Different Egyptian Governorates during 2021–2022

2023

Int J Vet Sci

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Rabbit hemorrhagic disease (RHD) outbreaks have occurred in Egyptian rabbit flocks resulting insignificant mortalities and severe economic losses. During 2021-2022, 20 samples were collected from different rabbit flocks with age range of 20 days to 6 months with high mortality rates, clinical symptoms, and post-mortem lesions attributed to rabbit hemorrhagic disease. The examined rabbit flocks were in Lower Egypt governorates including Qalubia, Sharkia, Kafr ElSheikh, Dakhlia, Gharbia, and Behira, and in Upper Egypt governorates including Giza, Menia, Assuit, and Sohag. The present investigation aimed at molecular identification of the current rabbit hemorrhagic disease virus (RHDV) strains detected in distinct rabbit populations in various Egyptian governorates. Hemagglutination (HA) test and molecular characterization using a one-step reverse transcriptase-polymerase chain reaction (RT-PCR) targeting the partial VP60 of RHDV were utilized for identifying these agents. Sequencing and phylogenetic analysis were successfully conducted for genotyping RHDV strains. 17/20 (about 85%) farms were RHDV-positive, which was confirmed using HA test and RT-PCR. Two genotypes were identified through partial sequencing of theVP60 gene, six strains were clustered to RHDV2/b, and the other three strains were clustered to the RHDVa strain. According to the current study, RHDV2 has become the predominant strain threatening the rabbit populations in Lower Egypt governorates. On the contrary, the RHDVa strain continues to be a hazard to the rabbit flocks in Upper Egypt governorates including Giza, Menia, and Assuit.

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Border Health: Who's Guarding the Gate?

Ehnert

Galland

2009

Veterinary Clinics of North America: Small Animal Practice

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Changes in the global trade market have led to a thriving international pet trade in exotic animals, birds, and puppies. The flood of animals crossing the United States' borders satisfies the public demand for these pets but is not without risk. Imported pets may be infected with diseases that put animals or the public at risk. Numerous agencies work together to reduce the risk of animal disease introduction, but regulations may need to be modified to ensure compliance. With more than 280,000 dogs and 183,000 wildlife shipments being imported into the United States each year, veterinarians must remain vigilant so they can recognize potential threats quickly.

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Rabbit hemorrhagic disease

Cited by 8 publications

References 7 publications

Preclinical models of acute liver failure: a comprehensive review

Preclinical models of acute liver failure: a comprehensive review

Epidemiology of Rabbit Hemorrhagic Disease Virus in Different Egyptian Governorates during 2021–2022

Border Health: Who's Guarding the Gate?

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