1974
DOI: 10.1136/sti.50.6.421
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Rabbit globulin and antiglobulin factors associated with Treponema pallidum growth in rabbits.

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Cited by 13 publications
(13 citation statements)
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“…Normal rabbit serum gave some level of protection against a challenge with T. pallidum (Table 3), and consequently all comparisons were made between transfer with immune and normal serum rather than with no serum. The presence of rabbit protein on the surface of the introduced T. pallidum (Logan 1974) may have resulted in a cross-reaction to allotypic differences in these proteins owing to the immunisation of the recipient rabbit with the transferred immune rabbit serum proteins nine days before challenge.…”
Section: Discussionmentioning
confidence: 99%
“…Normal rabbit serum gave some level of protection against a challenge with T. pallidum (Table 3), and consequently all comparisons were made between transfer with immune and normal serum rather than with no serum. The presence of rabbit protein on the surface of the introduced T. pallidum (Logan 1974) may have resulted in a cross-reaction to allotypic differences in these proteins owing to the immunisation of the recipient rabbit with the transferred immune rabbit serum proteins nine days before challenge.…”
Section: Discussionmentioning
confidence: 99%
“…This finding initially raised the possibility that most of the specific anti-T. pallidum hybridomas may be directed against intracellular rather than surface antigens of the T. pallidum organism. However, it has not been determined whether the sonication process releases intracellular T. pallidum components (against which the monoclonal antibodies are directed), or if sonication actually exposes or "unmasks" surface determinants of T. pallidum that are normally unexposed or coated with host proteins (1) or mucopolysaccharide (11,12,14,15,20,25,60,65). Indeed, the previously observed binding of these components to the surface of T. pallidum may be an important pathogenetic mechanism that protects the organism from the immune response of the host (16, 17, 30,33,35,38).…”
Section: Igg2bmentioning
confidence: 99%
“…Although T. pallidum carries host immunoglobulins on its surface (1,25), the anti-ITF antibodies could not have been directed to rabbit allotypes, as the animals used for ITF production and subsequent immunization were of the same allotype (Ab4/Ab4). We have further tested rabbit antisera to various rabbit allotypes and found that only rabbit antiserum to allotype 5 reacts with T. pallidum on commercial slides.…”
Section: Discussionmentioning
confidence: 99%