Rabbit Elastase Aneurysm: Imaging and Histology Correlates for Inflammation and Healing

Ho, Ja‐an Annie; Galex, Ilana; Weledji, Nelly; Bermudez, Sofia I. Cabello; Mitchell, Brook; Bush, Danielle M.; Yap, Edward; Davis, Neil; Catalino, Michael P; Godfrey, Virginia; Nielsen, Judith N.; Lee, Yueh Z.; Sasaki‐Adams, Deanna

doi:10.1016/j.wneu.2020.12.134

Cited by 7 publications

(2 citation statements)

References 28 publications

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“…Animal experiments have revealed a general vascular protective effect of the two drug groups ( 31 ). In rodent models with rabbit elastase aneurysms, ASA intake prevented inflammation of the periadventitial tissue and vessel wall ( 32 , 33 ). Comparable findings were obtained in humans, whereby ASA had the same beneficial influence on intracranial aneurysms, resulting in a lowered rupture risk ( 34 – 37 ).…”

Section: Discussionmentioning

confidence: 99%

Effects of medication intake on the risk of hemorrhage in patients with sporadic cerebral cavernous malformations

Chen

Lahl²,

Saban³

et al. 2023

Front. Neurol.

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ObjectiveRecurrent intracerebral hemorrhage (ICH) poses a high risk for patients with cerebral cavernous malformations (CCMs). This study aimed to assess the influence of medication intake on hemorrhage risk in sporadic CCMs.MethodsFrom a database of 1,409 consecutive patients with CCM (2003–2021), subjects with sporadic CCMs and complete magnetic resonance imaging data were included. We evaluated the presence of ICH as a mode of presentation, the occurrence of ICH during follow-up, and medication intake, including beta blockers, statins, antithrombotic therapy, and thyroid hormones. The impact of medication intake on ICH at presentation was calculated using univariate and multivariate logistic regression with age and sex adjustment. The longitudinal cumulative 5-year risk for (re-)hemorrhage was analyzed using the Kaplan–Meier curves and the Cox regression analysis.ResultsA total of 1116 patients with CCM were included. Logistic regression analysis showed a significant correlation (OR: 0.520, 95% CI: 0.284–0.951, p = 0.034) between antithrombotic therapy and ICH as a mode of presentation. Cox regression analysis revealed no significant correlation between medication intake and occurrence of (re-)hemorrhage (hazard ratios: betablockers 1.270 [95% CI: 0.703–2.293], statins 0.543 [95% CI: 0.194–1.526], antithrombotic therapy 0.507 [95% CI: 0.182–1.410], and thyroid hormones 0.834 [95% CI: 0.378–1.839]).ConclusionIn this observational study, antithrombotic treatment was associated with the tendency to a lower rate of ICH as a mode of presentation in a large cohort of patients with sporadic CCM. Intake of beta blockers, statins, and thyroid hormones had no effect on hemorrhage as a mode of presentation. During the 5-year follow-up period, none of the drugs affected the further risk of (re-)hemorrhage.

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Section: Discussionmentioning

confidence: 99%

Effects of medication intake on the risk of hemorrhage in patients with sporadic cerebral cavernous malformations

Chen

Lahl²,

Saban³

et al. 2023

Front. Neurol.

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“…[ 176 ] 2020 X Surgical Rabbits Fusiform X X Fries F. [ 177 ] 2020 X Surgical Rabbits Saccular X X Sun X. [ 178 ] 2020 X Endogenous Rabbits Saccular X Koseki H. [ 179 ] 2020 X Endogenous Rats Saccular X Ho J.P. [ 180 ] 2021 X Surgical Rabbits Saccular X …”

Section: Methodsmentioning

confidence: 99%

Imaging of intracranial aneurysms in animals: a systematic review of modalities

et al. 2023

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Intracranial aneurysm (IA) animal models are paramount to study IA pathophysiology and to test new endovascular treatments. A number of in vivo imaging modalities are available to characterize IAs at different stages of development in these animal models. This review describes existing in vivo imaging techniques used so far to visualize IAs in animal models. We systematically searched for studies containing in vivo imaging of induced IAs in animal models in PubMed and SPIE Digital library databases between 1 January 1945 and 13 July 2022. A total of 170 studies were retrieved and reviewed in detail, and information on the IA animal model, the objective of the study, and the imaging modality used was collected. A variety of methods to surgically construct or endogenously induce IAs in animals were identified, and 88% of the reviewed studies used surgical methods. The large majority of IA imaging in animals was performed for 4 reasons: basic research for IA models, testing of new IA treatment modalities, research on IA in vivo imaging of IAs, and research on IA pathophysiology. Six different imaging techniques were identified: conventional catheter angiography, computed tomography angiography, magnetic resonance angiography, hemodynamic imaging, optical coherence tomography, and fluorescence imaging. This review presents and discusses the advantages and disadvantages of all in vivo IA imaging techniques used in animal models to help future IA studies finding the most appropriate IA imaging modality and animal model to answer their research question.

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Balloon neck-plasty to create a wide-necked aneurysm in the elastase-induced rabbit model

Won,

Lee,

Park

et al. 2024

Neuroradiology

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Rabbit Elastase Aneurysm: Imaging and Histology Correlates for Inflammation and Healing

Cited by 7 publications

References 28 publications

Effects of medication intake on the risk of hemorrhage in patients with sporadic cerebral cavernous malformations

Effects of medication intake on the risk of hemorrhage in patients with sporadic cerebral cavernous malformations

Imaging of intracranial aneurysms in animals: a systematic review of modalities

Balloon neck-plasty to create a wide-necked aneurysm in the elastase-induced rabbit model

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