“…Additionally, several Rabs, such as Rab4, 5, 7, 9, 11 and 22 (Grant and Donaldson, 2009; Pfeffer, 2013; Stenmark, 2009; Zerial and McBride, 2001), and their multiple effectors or tethering proteins, like Rabenosyn-5, Rabaptin-5, Rabip4’, EEA1 and the HOPS complex, have been shown to localize to these domains (de Renzis et al, 2002; Deneka et al, 2003; Fouraux et al, 2004; Ivan et al, 2012; Kalin et al, 2015; Zhu et al, 2009) for the regulation of different cargo transport processes. Furthermore, Rab7 and 9 have been shown to control different transport steps during melanosome biogenesis by functioning on late endosomes (LEs) or melanosomes (Hida et al, 2011; Mahanty et al, 2016). Nonetheless, function of Rab4A in regulating the trafficking of melanocytic cargo during melanosome maturation has not been studied.…”