2006
DOI: 10.1111/j.1600-0854.2006.00395.x
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Rab6A and Rab6A′ GTPases Play Non‐overlapping Roles in Membrane Trafficking

Abstract: a These authors contributed equally to this work.

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Cited by 124 publications
(113 citation statements)
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“…To cite a few, transport between the ER and Golgi complex is regulated by Rab1 and Rab2 which orchestrate specificity in fusion with membranes at the cisGolgi (4 -6). At the level of the Golgi complex, Rab6a regulates trafficking in both a retrograde (from early endosomes and Golgi to the ER) and an anterograde (from the Golgi to the plasma membrane) direction (7)(8)(9)(10)(11)(12)(13). Transport from the Golgi to the plasma membrane can follow several paths.…”
Section: Previous Reports By Us and Others Demonstrated That G Proteimentioning
confidence: 99%
“…To cite a few, transport between the ER and Golgi complex is regulated by Rab1 and Rab2 which orchestrate specificity in fusion with membranes at the cisGolgi (4 -6). At the level of the Golgi complex, Rab6a regulates trafficking in both a retrograde (from early endosomes and Golgi to the ER) and an anterograde (from the Golgi to the plasma membrane) direction (7)(8)(9)(10)(11)(12)(13). Transport from the Golgi to the plasma membrane can follow several paths.…”
Section: Previous Reports By Us and Others Demonstrated That G Proteimentioning
confidence: 99%
“…S5). In addition, another report demonstrated that knocking down the expression of Rab6a hampers the intracellular transport of the retrograde cargo marker, the Shiga Toxin B subunit along the endocytic pathway 34 . Thus, we concluded that Rab6a-mediated dynein activation is critically important for cargo loading in vivo.…”
Section: Rab6a(q72l) Releases Lis1 and Activates Dynein Motilitymentioning
confidence: 99%
“…The siRNA sequence against Rab4A (sense 5Ј-GCCAGAACAUUGUGAUCAUd(TT)-3Ј) was kindly provided by M. Cormont (Faculté de Médecine de Nice, Nice, France). The siRNAs against Rab6A/AЈ (Del Nery et al, 2006) and against Rab5A were published previously (Huang et al, 2004), whereas the siRNAs against RCP and Rip11 were described by Peden et al (2004). Cells were transfected with the siRNAs, by using Lipofectamine 2000 (Invitrogen) according to the manufacturer's instructions.…”
Section: Rna Interferencementioning
confidence: 99%