Rab44-knockout mice exhibit reduced progression of inflammation in collagen antibody-induced arthritis
Yu Yamaguchi,
Tomoko Kadowaki,
Eiko Sakai
et al.
Abstract:Objective:Rheumatoid arthritis (RA) is an autoimmune disease characterized by immune cell-mediated joint inflammation and subsequent osteoclast-dependent bone destruction. This study aimed to investigate whether Rab44 is involved in RA because Rab44 is predominantly distributed in immune cells and osteoclasts.
Methods: Collagen antibody-induced arthritis (CAIA) was induced in Rab44-knockout (KO) and wild type (WT) mice. Arthritis severity was assessed daily for 4–9 days by macroscopic observation. Histopatholo… Show more
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