Rab27 GTPases Distribute Extracellular Nanomaps for  Invasive Growth and Metastasis: Implications for  Prognosis and Treatment

Hendrix, An; Wever, Olivier De

doi:10.3390/ijms14059883

Cited by 32 publications

(40 citation statements)

References 39 publications

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“…Rab27a and Rab27b, as well as their effector proteins, are important regulators of exosome release [77,163]. Interestingly, silencing Rab27a by RNA interference disrupted exosome-dependent and -independent mechanisms that modify the tumor microenvironment and can also reduce tumor growth and metastasis [164].…”

Section: Exosome-based Diagnostics and Therapeuticsmentioning

confidence: 99%

Exosomes: From Garbage Bins to Promising Therapeutic Targets

Rashed

Bayraktar

Helal

et al. 2017

IJMS

403

333

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Intercellular communication via cell-released vesicles is a very important process for both normal and tumor cells. Cell communication may involve exosomes, small vesicles of endocytic origin that are released by all types of cells and are found in abundance in body fluids, including blood, saliva, urine, and breast milk. Exosomes have been shown to carry lipids, proteins, mRNAs, non-coding RNAs, and even DNA out of cells. They are more than simply molecular garbage bins, however, in that the molecules they carry can be taken up by other cells. Thus, exosomes transfer biological information to neighboring cells and through this cell-to-cell communication are involved not only in physiological functions such as cell-to-cell communication, but also in the pathogenesis of some diseases, including tumors and neurodegenerative conditions. Our increasing understanding of why cells release exosomes and their role in intercellular communication has revealed the very complex and sophisticated contribution of exosomes to health and disease. The aim of this review is to reveal the emerging roles of exosomes in normal and pathological conditions and describe the controversial biological role of exosomes, as it is now understood, in carcinogenesis. We also summarize what is known about exosome biogenesis, composition, functions, and pathways and discuss the potential clinical applications of exosomes, especially as biomarkers and novel therapeutic agents.

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Section: Exosome-based Diagnostics and Therapeuticsmentioning

confidence: 99%

Exosomes: From Garbage Bins to Promising Therapeutic Targets

Rashed

Bayraktar

Helal

et al. 2017

IJMS

403

333

View full text Add to dashboard Cite

show abstract

“…The Rab27 family of small GTPases, as well as their effector proteins synaptotagmin-like protein 4 (Slp4) and synaptotagmin-like protein homologue lacking C2 domains b (Slac2b), have been found to be important regulators of exosome release [57, 58]. Alternatively, formation of microvesicles via direct shedding from the cancer cell surface may be controlled by specific signalling pathways triggered by Ras homolog family member A (RhoA) [59] and/or ADP-ribosylation factor 6 (Arf6) [60].…”

Section: Extracellular Vesicles: Emerging Targets For Cancer Therapymentioning

confidence: 99%

“…However, technological challenges related to EV isolation, purification and content analysis remain. For example, for multicentre validation studies, standardized isolation and characterization methods are necessary, yet largely lacking [58]. To overcome some of these challenges, a novel platform has recently been described for rapid protein profiling of EV samples.…”

Section: Figurementioning

confidence: 99%

Extracellular vesicles: emerging targets for cancer therapy

Vader

Breakefield

Wood

2014

Trends in Molecular Medicine

361

297

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Extracellular vesicles (EVs), including exosomes, microvesicles and apoptotic bodies, are released by almost all cell types, including tumour cells. Through transfer of their molecular contents, EVs are capable of altering the function of recipient cells. Increasing evidence suggests a key role for EV-mediated intercellular communication in a variety of cellular processes involved in tumour development and progression, including immune suppression, angiogenesis and metastasis. Aspects of EV biogenesis or function are therefore increasingly being considered as targets for anti-cancer therapy. Here, we summarize the current knowledge on the contributions of EVs to cancer pathogenesis and discuss novel therapeutic strategies to target EVs to prevent tumour growth and spread.

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“…The study demonstrated that the presence of Rab27 was significantly correlated with reduced overall survival. 137 Mutlivariate analyses also implicated Rab3c as a prognostic marker in both early and later stage colon cancer patients, as high Rab3c expression influenced cancer stage and subsequent therapy. 138 This opens the doors to the development of new therapeutic methods to target these necessary proteins such as siRNA or peptide manipulations that can selectively affect Rab effectors.…”

Section: Resultsmentioning

confidence: 99%

The role of endocytic Rab GTPases in regulation of growth factor signaling and the migration and invasion of tumor cells

Porther

Barbieri

2015

Small GTPases

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Metastasis is characterized pathologically by uncontrolled cell invasion, proliferation, migration and angiogenesis. It is a multistep process that encompasses the modulation of membrane permeability and invasion, cell spreading, cell migration and proliferation of the extracellular matrix, increase in cell adhesion molecules and interaction, decrease in cell attachment and induced survival signals and propagation of nutrient supplies (blood vessels). In cancer, a solid tumor cannot expand and spread without a series of synchronized events. Changes in cell adhesion receptor molecules (e.g., integrins, cadherin-catenins) and protease expressions have been linked to tumor invasion and metastasis. It has also been determined that ligand-growth factor receptor interactions have been associated with cancer development and metastasis via the endocytic pathway. Specifically, growth factors, which include IGF-1 and IGF-2 therapy, have been associated with most if not all of the features of metastasis. In this review, we will revisit some of the key findings on perhaps one of the most important hallmarks of cancer metastasis: cell migration and cell invasion and the role of the endocytic pathway in mediating this phenomenon

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Rab27 GTPases Distribute Extracellular Nanomaps for Invasive Growth and Metastasis: Implications for Prognosis and Treatment

Cited by 32 publications

References 39 publications

Exosomes: From Garbage Bins to Promising Therapeutic Targets

Exosomes: From Garbage Bins to Promising Therapeutic Targets

Extracellular vesicles: emerging targets for cancer therapy

The role of endocytic Rab GTPases in regulation of growth factor signaling and the migration and invasion of tumor cells

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