Rab11‐FIP1 mediates epithelial‐mesenchymal transition and invasion in esophageal cancer

Tang, Qiaosi; Lento, Ashley; Suzuki, Kensuke; Efe, Gizem; Karakasheva, Tatiana A.; Long, Apple; Giroux, Véronique; Islam, Mirazul; Wileyto, E. Paul; Klein‐Szanto, Andres J.; Nakagawa, Hiroshi; Bass, Adam J.; Rustgi, Anil K.

doi:10.15252/embr.201948351

Cited by 16 publications

(6 citation statements)

References 32 publications

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“…This protein is a partner of Rab11 and Rab25, which ensures the recycling of receptors from endosomes to the plasma membrane. However, the loss of its expression activated EMT along the Zeb1-mediated transcriptional program ( Tang et al, 2021 ). In a mouse model of ovarian cancer, it was demonstrated that wild-type p53 induced phosphatase 1 (Wip 1) blocks EMT by affecting the activity of ATM kinase.…”

Section: Effects On Emt Via Signalling Pathways Re...mentioning

confidence: 99%

Opposing Roles of Wild-type and Mutant p53 in the Process of Epithelial to Mesenchymal Transition

Semenov

Daks

Fedorova

et al. 2022

Front. Mol. Biosci.

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The central role of an aberrantly activated EMT program in defining the critical features of aggressive carcinomas is well documented and includes cell plasticity, metastatic dissemination, drug resistance, and cancer stem cell-like phenotypes. The p53 tumor suppressor is critical for leashing off all the features mentioned above. On the molecular level, the suppression of these effects is exerted by p53 via regulation of its target genes, whose products are involved in cell cycle, apoptosis, autophagy, DNA repair, and interactions with immune cells. Importantly, a set of specific mutations in the TP53 gene (named Gain-of-Function mutations) converts this tumor suppressor into an oncogene. In this review, we attempted to contrast different regulatory roles of wild-type and mutant p53 in the multi-faceted process of EMT.

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Section: Effects On Emt Via Signalling Pathways Re...mentioning

confidence: 99%

Opposing Roles of Wild-type and Mutant p53 in the Process of Epithelial to Mesenchymal Transition

Semenov

Daks

Fedorova

et al. 2022

Front. Mol. Biosci.

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“…RAB11FIP1, also known as RCP, is a RAB-coupling protein. It may be a human breast cancer-promoting gene with Ras-activating function [65] , and can mediate epithelial-mesenchymal transition and invasion in esophageal cancer [66] . Some lncRNAs are also concerned due to their crucial roles in cancer.…”

Section: Discussionmentioning

confidence: 99%

Protein profiling reveals potential isomiR-associated cross-talks among RNAs in cholangiocarcinoma

Guo

Dou

Yang

et al. 2021

Computational and Structural Biotechnology Journal

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“…In esophageal cancer, RAB11FIP1 regulates EMT by directly inhibiting the key transcription factor ZEB1 of EMT. Recent findings suggest that RAB11FIP1 regulates organoid formation, tumor cell invasion, and EMT ( Tang et al, 2021 ). In the current study, we assured that RAB11FIP1 could be a prognostic biomarker.…”

Section: Discussionmentioning

confidence: 99%

RAB11FIP1: An Indicator for Tumor Immune Microenvironment and Prognosis of Lung Adenocarcinoma from a Comprehensive Analysis of Bioinformatics

Zhang

Chen

et al. 2021

Front. Genet.

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Lung adenocarcinoma (LUAD) was the first one all over the world. RAB11FIP1 was found to be expressed differently in a critical way among different cancers. However, the prognostic value and immune infiltration of RAB11FIP1 expression in LUAD are unclear. In this study, the expression of RAB11FIP1 in LUAD was investigated in the Oncomine, TCGA, GEO, and UALCAN databases. Kaplan-Meier analysis was chosen to compare the association between RAB11FIP1 expression and overall survival (OS) in LUAD patients. The dataset of TCGA was used to analyze the pertinence between RAB11FIP1 and clinicpathological factors. GO, KEGG, and network analysis of protein-protein interactions (PPI) were conducted to investigate the potential mechanism of RAB11FIP1. In the end, the relevance of RAB11FIP1 to cancer-immune infiltrates was investigated. RAB11FIP1 was found to be down-regulated by tumors compared with adjacent normal tissue in multiple LUAD cohorts. RAB11FIP1 is an independent prognostic factor in lung adenocarcinoma. There was a high correlation between low RAB11FIP1 in tumors and worse OS in LUAD. Functional network analysis suggested that RAB11FIP1 was associated with multiple pathways. Besides, the expression of RAB11FIP1 was closely related to the infiltration levels of B cell, CD8+ T cells, CD4+ T cells, macrophages, neutrophils, and dendritic cells. RAB11FIP1 expression in LUAD occurred with a variety of immune markers. Our findings suggest that RAB11FIP1 is related to prognosis and immune infiltrates in LUAD.

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Rab11‐FIP1 mediates epithelial‐mesenchymal transition and invasion in esophageal cancer

Cited by 16 publications

References 32 publications

Opposing Roles of Wild-type and Mutant p53 in the Process of Epithelial to Mesenchymal Transition

Opposing Roles of Wild-type and Mutant p53 in the Process of Epithelial to Mesenchymal Transition

Protein profiling reveals potential isomiR-associated cross-talks among RNAs in cholangiocarcinoma

RAB11FIP1: An Indicator for Tumor Immune Microenvironment and Prognosis of Lung Adenocarcinoma from a Comprehensive Analysis of Bioinformatics

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