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Santangelo, Francesco

doi:10.1007/s00726-002-0206-y

Cited by 13 publications

(3 citation statements)

References 37 publications

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“…SAA levels are well known to change during sepsis [ 20 , 21 ]. From our results, we demonstrated that severe sepsis patients and non-survivors had lower SAA concentrations.…”

Section: Discussionmentioning

confidence: 99%

Dynamic Changes in Amino Acid Concentration Profiles in Patients with Sepsis

et al. 2015

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ObjectivesThe goal of this work was to explore the dynamic concentration profiles of 42 amino acids and the significance of these profiles in relation to sepsis, with the aim of providing guidance for clinical therapies.MethodsThirty-five critically ill patients with sepsis were included. These patients were further divided into sepsis (12 cases) and severe sepsis (23 cases) groups or survivor (20 cases) and non-survivor (15 cases) groups. Serum samples from the patients were collected on days 1, 3, 5, 7, 10, and 14 following intensive care unit (ICU) admission, and the serum concentrations of 42 amino acids were measured.ResultsThe metabolic spectrum of the amino acids changed dramatically in patients with sepsis. As the disease progressed further or with poor prognosis, the levels of the different amino acids gradually increased, decreased, or fluctuated over time. The concentrations of sulfur-containing amino acids (SAAs), especially taurine, decreased significantly as the severity of sepsis worsened or with poor prognosis of the patient. The serum concentrations of SAAs, especially taurine, exhibited weak negative correlations with the Sequential Organ Failure Assessment (SOFA) (r=-0.319) and Acute Physiology and Chronic Health Evaluation (APACHE) II (r=-0.325) scores. The areas under the receiver operating characteristic curves of cystine, taurine, and SAA levels and the SOFA and APACHE II scores, which denoted disease prognosis, were 0.623, 0.674, 0.678, 0.86, and 0.857, respectively.ConclusionsCritically ill patients with disorders of amino acid metabolism, especially of SAAs such as cystine and taurine, may provide an indicator of the need for the nutritional support of sepsis in the clinic.Trial RegistrationClinicalTrial.gov identifier NCT01818830.

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“…SAA levels are well known to change during sepsis [ 20 , 21 ]. From our results, we demonstrated that severe sepsis patients and non-survivors had lower SAA concentrations.…”

Section: Discussionmentioning

confidence: 99%

Dynamic Changes in Amino Acid Concentration Profiles in Patients with Sepsis

et al. 2015

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“…When the organism enters the bloodstream, the concentration of cysteine in human blood plasma is only approximately 30 to 60 μM (65, 66). During inflammation with sepsis, the cysteine concentration is significantly decreased (67, 68). N.…”

Section: Discussionmentioning

confidence: 99%

The Meningococcal Cysteine Transport System Plays a Crucial Role in Neisseria meningitidis Survival in Human Brain Microvascular Endothelial Cells

Takahashi

Watanabe

Kim

et al. 2018

mBio

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Neisseria meningitidis colonizes at a nasopharynx of human as a unique host and has many strains that are auxotrophs for amino acids for their growth. To cause invasive meningococcal diseases (IMD) such as sepsis and meningitis, N. meningitidis passes through epithelial and endothelial barriers and infiltrates into blood and cerebrospinal fluid as well as epithelial and endothelial cells. However, meningococcal nutrients, including cysteine, become less abundant when it more deeply infiltrates the human body even during inflammation, such that N. meningitidis has to acquire nutrients in order to survive/persist, disseminate, and proliferate in humans. This was the first study to examine the relationship between meningococcal cysteine acquisition and the pathogenesis of meningococcal infections. The results of the present study provide insights into the mechanisms by which pathogens with auxotrophs acquire nutrients in hosts and may also contribute to the development of treatments and prevention strategies for IMD.

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“…Tau is regarded as an antioxidant and membrane stabilizer against oxidative stress and inflammation by inhibiting chemokine secretion from intestinal cells [85, 86]. Moreover, the cellular metabolite taurine chloramine of Tau in the rectal shows anti-inflammatory property on IBD via inhibition on NF- κ B activity [44, 87].…”

Section: Amino Acids: Application In Inflammatory Bowel Disease Thmentioning

confidence: 99%

Roles of Dietary Amino Acids and Their Metabolites in Pathogenesis of Inflammatory Bowel Disease

Bao

Feng

Yao³

et al. 2017

Mediators of Inflammation

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Inflammatory Bowel Disease (IBD) is a kind of chronic inflammation, which has increasing incidence and prevalence in recent years. IBD mainly divides into Crohn's disease (CD) and ulcerative colitis (UC). It is hard to cure IBD completely, and novel therapies are urgently needed. Amino acids (AAs) and their metabolites are regarded as important nutrients for humans and animals and also play an important role in IBD amelioration. In the present study, the potential protective effects of AAs and their metabolites on IBD had been summarized with the objective to provide insights into IBD moderating using dietary AAs and their metabolites as a potential adjuvant therapy.

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Untitled

Cited by 13 publications

References 37 publications

Dynamic Changes in Amino Acid Concentration Profiles in Patients with Sepsis

Dynamic Changes in Amino Acid Concentration Profiles in Patients with Sepsis

The Meningococcal Cysteine Transport System Plays a Crucial Role in Neisseria meningitidis Survival in Human Brain Microvascular Endothelial Cells

Roles of Dietary Amino Acids and Their Metabolites in Pathogenesis of Inflammatory Bowel Disease

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