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Abstract

Objectives:To compare efficacy and safety of topical plus reduced dose of diclofenac to oral diclofenac in therapeutic dose. Method: The study was prospective, comparative and randomized, which included 50 patients suffering from knee osteoarthritis. Patients were randomized to receive either -oral diclofenac alone (50 mg thrice daily) (therapy1) or decreased dose of oral diclofenac and topical diclofenac (75 mg SR once daily + 10 mg Nanogel thrice daily) (therapy 2). The patients had been followed up for 7 days. Visual Analogue Scale and Lequesne Index has been used to evaluate the efficacy. Adverse drug reaction form, WHO and Naranjo Causality Assessment Scale were used to evaluate the safety of the patients. Data were analyzed by independent student t-test. Results: Out of 50 patients 17 were male and 33 were female.