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Zhigacheva, I. V.; Burlakova, E. B.; Evseenko, L. S.; Kaplan, Ervin; Krivosheeva, L. V.; Bulanova, Elena; Никонова, М Ф; Литвина, М М; Khristianovich, D. S.; Воронков, М. Г.

doi:10.1023/a:1015381622241

Cited by 5 publications

(2 citation statements)

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“…Studies have suggested that oxidative stress-induced lipid peroxidation may play a role in toxic responses to PAH in immunological systems. For example, Zhigacheva et al found that the increased lipid peroxidation products were linked to modification of leucocyte membranes and reduced activity of lymphocyte enzymes in animals after 6 months of PAH inhalation as compared with controls [44]. In addition, moderate activation of lipid peroxidation and oxidative damage as determined by plasma MDA and 8-OHdG levels were detected simultaneously with significant alterations in IgA and IgE levels described by Jeng et al [42].…”

Section: Discussionmentioning

confidence: 99%

Lymphocyte Oxidative Stress/Genotoxic Effects Are Related to Serum IgG and IgA Levels in Coke Oven Workers

Gao

Zheng

et al. 2014

The Scientific World Journal

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We investigated oxidative stress/genotoxic effects levels, immunoglobulin levels, polycyclic aromatic hydrocarbons (PAHs) levels exposed in 126 coke oven workers and in 78 control subjects, and evaluated the association between oxidative stress/genotoxic effects levels and immunoglobulin levels. Significant differences were observed in biomarkers, including 1-hydroxypyrene levels, employment time, percentages of alcohol drinkers, MDA, 8-OHdG levels, CTL levels and CTM, MN, CA frequency, and IgG, IgA levels between the control and exposed groups. Slightly higher 1-OHP levels in smoking users were observed. For the dose-response relationship of IgG, IgA, IgM, and IgE by 1-OHP, each one percentage increase in urinary 1-OHP generates a 0.109%, 0.472%, 0.051%, and 0.067% decrease in control group and generates a 0.312%, 0.538%, 0.062%, and 0.071% decrease in exposed group, respectively. Except for age, alcohol and smoking status, IgM, and IgE, a significant correlation in urinary 1-OHP and other biomarkers in the total population was observed. Additionally, a significant negative correlation in genotoxic/oxidative damage biomarkers of MDA, 8-OH-dG, CTL levels, and immunoglobins of IgG and IgA levels, especially in coke oven workers, was found. These data suggest that oxidative stress/DNA damage induced by PAHs may play a role in toxic responses for PAHs in immunological functions.

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Section: Discussionmentioning

confidence: 99%

Lymphocyte Oxidative Stress/Genotoxic Effects Are Related to Serum IgG and IgA Levels in Coke Oven Workers

Gao

Zheng

et al. 2014

The Scientific World Journal

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“…Immuno-suppression was indicated to be the most common effect after PAH exposure and was suggested to be a mechanism of PAH-induced cancer and the increased sensitivity of individuals to the development of infectious diseases [ 46 ]. The decrease in humoral immunity is due to the modification of leukocyte membranes caused by activated lipid peroxidation (LPO), a process that ROS targets cell membranes and induces autocatalytic oxidation, which could also lead to decreased activity of lymphocyte enzymes and reduced number of spleen cells [ 47 , 48 ]. PAHs were observed to reduce the number of splenic B lymphocytes, inhibit antibody production, and decrease the number of antigen-specific responder B cells [ 49 , 50 ].…”

Section: How Pahs Influence the Human Bodymentioning

confidence: 99%