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Giron, D.

doi:10.1023/a:1016015113795

Cited by 214 publications

(35 citation statements)

References 75 publications

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“…Combined or coupled thermal analysis techniques were found to provide quicker ways for interpretation of polymorphic phenomena, while at the same time, the sensitivity, the reliability and the robustness of the results remain of high quality [18,19]. This is illustrated by a coupling of DSC and HSM, which have proved to be very successful in the study of phase diagrams and polymorphic transformation [20][21][22][23].…”

Section: Introductionmentioning

confidence: 99%

A combined approach of differential scanning calorimetry and hot-stage microscopy with image analysis in the investigation of sulfathiazole polymorphism

Bakar

Nagy

Rielly

2009

J Therm Anal Calorim

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Section: Introductionmentioning

confidence: 99%

A combined approach of differential scanning calorimetry and hot-stage microscopy with image analysis in the investigation of sulfathiazole polymorphism

Bakar

Nagy

Rielly

2009

J Therm Anal Calorim

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“…can also be studied. Several investigations have been carried out on the application of thermal methods in pharmaceutical industry (10)(11)(12)(13)(14)(15) . In present paper, thermal properties of some imidazolinone derivatives have been studied by using TGA technique.…”

Section: Introductionmentioning

confidence: 99%

Thermal Analysis of some Imidazolinone Derivatives

Baluja

Kachhadia

2015

ILCPA

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Thermal analysis of some imidazolinone derivatives derived from 1, N-phenyl-3-p-nitrophenyl-4-formyl pyrazole, have been carried out by TGA technique. From these thermograms, various kinetic parameters such as order of degradation (n), energy of activation (E), frequency factor (A) and entropy change (∆S) have been evaluated. Further, thermal stability of imidazolinone derivatives have been determined, which is found to depend on the type of substituent present in the compounds.

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“…These methods have been reviewed in detail by many authors [7][8][9][10][11][12]. The most useful information about crystallography such as crystalline structure and absolute molecular configuration is, of course, brought by single-crystal XRD however one disadvantage is that it is required that the sample crystal is large enough to be studied by this technique.…”

Section: Introductionmentioning

confidence: 99%

Characterization of Pharmaceutical Polymorphs by Isothermal Calorimetry

Urakami¹

2005

CPB

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A great number of pharmaceutical substances exist in crystalline solid-state. Because of the complexity of their chemical structure many different polymorphs of a given substance can exist. Polymorphic forms of solid pharmaceuticals influence not only their dissolution behavior, i.e. bioavailability but also their solid-state stability. It is well known that only one polymorphic form is thermodynamically stable and all other metastable forms will convert, eventually, to the more stable form. Hence it is essential to choose the most suitable polymorphic form in the early stage of pharmaceutical development. The following article reviews the recent applications of solution calorimetry that allows characterization of pharmaceutical polymorphs through accurate determination of enthalpy of solution. Each crystalline form possesses a defined enthalpy of solution, therefore solution calorimetry is used for the quantitative analysis of the desired polymorphic form and determination of enthalpy of transition corresponding to the difference in enthalpies of solution for a polymorphic pair. More recently this technique has been applied to the estimation of thermodynamic transition temperature, which is useful for the evaluation of thermodynamic stability relationships between polymorphs. This article will also describe the kinetics and thermodynamics of polymorphic transitions, from a metastable form to the thermodynamically stable form, through studies using ampoule-based isothermal microcalorimetry. Such studies are particularly useful when metastable forms are to be selected in order to enhance bioavailability. If the metastable form, or the pharmaceutical product containing it, can be shown to be sufficiently stable, it could then be used in a formulation where its therapeutic effects could be exploited.

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Untitled

Cited by 214 publications

References 75 publications

A combined approach of differential scanning calorimetry and hot-stage microscopy with image analysis in the investigation of sulfathiazole polymorphism

A combined approach of differential scanning calorimetry and hot-stage microscopy with image analysis in the investigation of sulfathiazole polymorphism

Thermal Analysis of some Imidazolinone Derivatives

Characterization of Pharmaceutical Polymorphs by Isothermal Calorimetry

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