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Pokorný, Jan; Jelínek, F; Trkal, Viktor; Lamprecht, I.; Hölzel, Ralph

doi:10.1023/a:1005092601078

Cited by 74 publications

(24 citation statements)

References 16 publications

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“…MTs also act as railways along which motor proteins move, 5,6 and form the moving cores of cilia and flagella. 7,8 Since mechanical properties of MTs are crucial to fulfill their role in various cellular functions, such as in cell division, cell motility, and intracellular transport, microtubule mechanics has been the topic of numerous recent theoretical and experimental research, especially those on mechanical vibration and wave propagation of microtubules, [9][10][11][12][13][14] and dynamics instability of microtubules. [15][16][17][18] In addition to various discrete methods of modeling, such as molecular mechanics or lattice models, continuum isotropic elastic beam models have been widely used to study rodlike mechanical behavior of microtubules, based on the concept of flexural rigidity of microtubules.…”

Section: Introductionmentioning

confidence: 99%

Wave propagation in orthotropic microtubules

Qian

Zhang

2007

Journal of Applied Physics

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For various cellular functions of microtubules, wave propagation along microtubules is one of the issues of major concern. In this article, general behavior of wave propagation in microtubules is examined based on an orthotropic elastic shell model, with particular emphasis on the role of strongly anisotropic elastic properties of microtubules. Strong anisotropy of microtubules is found to substantially lower both torsional and radial wave velocities, although it does not affect longitudinal wave velocity. In many cases, it is found that one of three wave velocities in orthotropic microtubules depends on wave vector nonmonotonically, and reaches a minimum velocity around a specific value of the wave vector. In particular, this interesting phenomenon would not exist if microtubules were isotropic. In addition, transverse bending waves of orthotropic microtubules always correspond to the lowest wave velocity, and can be determined by the (isotropic) elastic beam model provided the wavelength is long enough. Many of the results obtained in the present article have been absent from the literature on wave propagation in microtubules.

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Section: Introductionmentioning

confidence: 99%

Wave propagation in orthotropic microtubules

Qian

Zhang

2007

Journal of Applied Physics

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“…Penrose 82 related consciousness to the action of the cytoskeleton and to microtubules in particular. Generation of Fröhlich's polar vibrations in microtubules was proposed by Pokorný et al 30 The oscillations in the tubulin heterodimers in the microtubules interact with the ordered water and the free charges in the water inside the microtubule cavity that conditions the microtubule function. 32 The ordered water around microtubules provides low damping 49 and may also participate in the coherent oscillations.…”

Section: Discussionmentioning

confidence: 99%

“…Large dielectrophoretic effects of the yeast cells in the M phase (when cells divide and the microtubule activity is high) were measured by Pohl et al 14 Tuszyński et al 29 proved that heterodimers in microtubules are electric dipoles. Generation of the electromagnetic field by microtubules based on Fröhlich's mechanism of the electrical polar vibrations was proposed by Pokorný et al 30 Electric oscillations measured at the cellular membrane of living yeast cells in the M phase display enhanced electric activity in some periods coinciding with mitotic spindle formation, metaphase, and anaphase A and B. 19 Disruption of microtubule polymerization in cells by an external electromagnetic field at the frequency 0.1-0.3 MHz suggests microtubule electromagnetic activity in heterodimer attachment.…”

Section: Oscillations In Microtubulesmentioning

confidence: 99%

Cancer — Pathological Breakdown of Coherent Energy States

Pokorný

Kobilková

et al. 2014

Biophys. Rev. Lett.

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The fundamental property of biological systems is a coherent state far from thermodynamic equilibrium excited and sustained by energy supply. Mitochondria in eukaryotic cells produce energy and form conditions for excitation of oscillations in microtubules. Microtubule polar oscillations generate a coherent state far from thermodynamic equilibrium which makes possible cooperation of cells in the tissue. Mitochondrial dysfunction (the Warburg effect) in cancer development breaks down energy of the coherent state far from thermodynamic equilibrium and excludes the afflicted cell from the ordered multicellular tissue system. Cancer lowering of energy and coherence of the state far from thermodynamic equilibrium is the biggest difference from the healthy cells. Cancer treatment should target mitochondrial dysfunction to restore the coherent state far from thermodynamic equilibrium, apoptotic pathway, and subordination of the cell in the tissue. A vast variety of genetic changes and other disturbances in different cancers can result in several triggers of mitochondrial dysfunction. In cancers with the Warburg effect, mitochondrial dysfunction can be treated by inhibition of four isoforms of pyruvate dehydrogenase kinases. Treatment of the reverse Warburg effect cancers would be more complicated. Disturbances of cellular electromagnetic activity by conducting and asbestos fibers present a special problem of treatment.

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“…The mechanisms generating both magnetic fields and acoustic waves in plants may be driven by similar biochemical processes within the cell, where nanomechanical oscillations of various components in the cytoskeleton can generate a spectrum of vibrations spanning from low kHz up to GHz 25,26 and even up to THz. 27 Specifically, Corsini et al 23 suggested that electrical currents and time-varying…”

Section: Acoustic and Magnetic Communication In Plantsmentioning

confidence: 99%

Acoustic and magnetic communication in plants

Gagliano

Renton²,

Duvdevani

et al. 2012

Plant Signaling & Behavior

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Addendum to: Gagliano M, Renton M, Duvdevani N, Timmins M, Mancuso S. Out of sight but not out of mind: alternative means of communication in plants. PLoS One 2012; 7:e37382; http modalities remain to be discovered. In fact, we have recently found that seeds and seedlings of the chili plant, Capsicum annuum, are able to sense neighbors and identify relatives using alternative mechanisms beyond previously studied channels of plant communication. In this addendum, we offer a hypothetical mechanistic explanation as to how plants may do this by quantum-assisted magnetic and/or acoustic sensing and signaling. If proven correct, this hypothesis prompts for a re-interpretation of our current understanding of plasticity in germination and growth of plants and more generally, calls for developing a new perspective of these biological phenomena.The idea that plants communicate has long been a controversially debated topic, because the flow of information between plants was often thought to involve cues rather than actual signals. This distinction is important because signals are traits that evolved for a specific role in communication (see definition by ScottPhillips 1 ), while cues are only incidental features present in the environment that have not been shaped by natural selection to carry a specific meaning for intended

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Untitled

Cited by 74 publications

References 16 publications

Wave propagation in orthotropic microtubules

Wave propagation in orthotropic microtubules

Cancer — Pathological Breakdown of Coherent Energy States

Acoustic and magnetic communication in plants

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