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Abstract

Trigonella foenum graecum (fenugreek) seed powder has been suggested to have potential antidiabetic effects. The effect of oral administration of Trigonella whole seed powder (5% in the diet) for 21 days on glycolytic, gluconeogenic and NADP-linked lipogenic enzymes were studied in liver and kidney tissues of alloxan-induced diabetic Wistar rats. Diabetic rats were characterised by a 4-fold higher blood glucose level and a 0.7-fold lower body weight compared to normal controls. The activities of the glycolytic enzymes were significantly lower in the diabetic liver and higher in the diabetic kidney. The activities of gluconeogenic enzymes were higher in both liver and kidney during diabetes, however the activities of the lipogenic enzymes were decreased in both tissues during diabetes. Trigonella seed powder treatment to diabetic rats for 21 days brought down the elevated fasting blood glucose levels to control levels. The altered enzyme activities were significantly restored to control values in both the liver and kidney after Trigonella seed powder treatment. The therapeutic role of Trigonella seed powder in type-1 diabetes as exemplified in this study can be attributed to the change of glucose and lipid metabolising enzyme activities to normal values, thus stabilizing glucose homeostasis in the liver and kidney. These biochemical effects exerted by Trigonella seeds make it a possible new therapeutic in type-1 diabetes.

Fenugreek seeds reduce aluminum toxicityassociated with renal failure in rats

“…Indeed, supplementation of fenugreek seeds in the diets of diabetic rats reduced the hepatic and renal output of glucose by decreasing the levels of the two enzymes glucose-6-phosphatase and fructose-1-6 bisphosphatase in these organs [47]. Other studies have demonstrated that oral administration of fenugreek seed powder to alloxan-diabetic rats could improve glucose homeostasis by normalizing the different glycolytic, lipogenic and related enzyme changes in the liver and kidney [48]. Trigonella seed supplementation in the diet was also reported to partly prevent an increase in the renal glycogen content and a decrease in hepatic glycogen content with diabetes [36].…”

Prenatal Exposure to Fenugreek Impairs Sensorimotor Development and the Operation of Spinal Cord Networks in Mice

“…Today, fenugreek capsules are freely available, mainly as an appetite stimulant, but immunostimulatory, antidiabetic, antihypertensive and cholesterol-lowering properties have been put forward [2-4,28]. In view of the widespread use of fenugreek and the lack of medical monitoring, the safety of fenugreek seeds consumption during pregnancy turns out to be a public health concern.…”

“…Fenugreek seeds are commonly used worldwide for its laxative and galactagogue properties but also to stimulate appetite and prevent stomach ache [1]. More recently, immunostimulatory, antidiabetic, antihypertensive and cholesterol-lowering potentials have been described [2-4]. However, consumption of fenugreek seeds during pregnancy has been associated with congenital malformations, neonatal and birth defects [5,6].…”

Immunomodulatory and Antidiabetic Effects of a New Herbal Preparation (HemoHIM) on Streptozotocin‐Induced Diabetic Mice

“…However, loss of body weight was suppressed by HemoHIM. Failure of STZ-induced diabetic animal models to gain body weight has already been reported [29, 30]. Kidney and liver weights are higher in diabetic animals, as STZ-induced diabetic animals undergo glomerular hypertrophy [31] and triglyceride accumulation [30] in the kidney and liver, respectively.…”

“…Failure of STZ-induced diabetic animal models to gain body weight has already been reported [29, 30]. Kidney and liver weights are higher in diabetic animals, as STZ-induced diabetic animals undergo glomerular hypertrophy [31] and triglyceride accumulation [30] in the kidney and liver, respectively. In the current study, HemoHIM attenuated hypertrophy of organs (kidney, liver, and lung) and the thymus in STZ-induced diabetic mice [32, 33].…”