R1ρ at high spin-lock frequency could be a complementary imaging biomarker for liver iron overload quantification

Wang, Qianfeng; Xiao, Han; Yu, Xuchen; Lin, Huimin; Yang, Baofeng; Zhang, Yuwen; Feng, Danyang; Yan, Fuhua; He, Wei

doi:10.1016/j.mri.2020.10.014

Cited by 2 publications

(1 citation statement)

References 43 publications

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“…33,34 Moonen et al 44 reported the change of R 1ρ at various FSLs in presence of iron particles with different coating materials using in vitro experiment. Wang et al 45 analyzed the sensitivity of R 1ρ and CPMG R 2 to LIC at 11.7T and observed a statistically significant linear association between R 1ρ and LIC when the FSL was higher than 2000 Hz. This observation supports our proposed approach.…”

Section: Discussionmentioning

confidence: 99%

Characterization and correction of the effects of hepatic iron on T_1ρ relaxation in the liver at 3.0T

Qian

Hou

Jiang

et al. 2022

Magnetic Resonance in Med

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Purpose Quantitative T1ρ imaging is an emerging technique to assess the biochemical properties of tissues. In this paper, we report our observation that liver iron content (LIC) affects T1ρ quantification of the liver at 3.0T field strength and develop a method to correct the effect of LIC. Theory and Methods On‐resonance R1ρ (1/T1ρ) is mainly affected by the intrinsic R2 (1/T2), which is influenced by LIC. As on‐resonance R1ρ is closely related to the Carr–Purcell–Meiboom–Gill (CPMG) R2, and because the calibration between CPMG R2 and LIC has been reported at 1.5T, a correction method was proposed to correct the R2 contribution to the R1ρ. The correction coefficient was obtained from the calibration results and related transformed factors. To compensate for the difference between CPMG R2 and R1ρ, a scaling factor was determined using the values of CPMG R2 and R1ρ, obtained simultaneously from a single breath‐hold from volunteers. The livers of 110 subjects were scanned to validate the correction method. Results LIC was significantly correlated with R1ρ in the liver. However, when the proposed correction method was applied to R1ρ, LIC and the iron‐corrected R1ρ were not significantly correlated. Conclusion LIC can affect T1ρ in the liver. We developed an iron‐correction method for the quantification of T1ρ in the liver at 3.0T.

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Section: Discussionmentioning

confidence: 99%

Characterization and correction of the effects of hepatic iron on T_1ρ relaxation in the liver at 3.0T

Qian

Hou

Jiang

et al. 2022

Magnetic Resonance in Med

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Comparison of R1ρ Imaging Between Rapid Acquisition with Relaxation Enhancement (RARE) and Ultrashort TE (UTE) Sequence in the Assessment of Rat Liver Iron Overload at 11.7T

Liu

Xiao

Wang

et al. 2023

CMIR

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Introduction: Since the most prominent effect of iron is increasing R2* and R2 relaxation rates, the iron-overload liver shows little signal with conventional T1ρ sequences like RARE. Whereas, with UTE MR imaging sequences, the signal can be detected from short T2/T2* relaxation components in tissues. This study aims to evaluate the difference in R1ρ profiles and compare the correlations between RARE-based and UTE-based sequences with LIC in the assessment of rat liver iron overload. Methods: Iron dextran (Sigma, 100 mg Fe/ml) was injected into thirty-five rats (25-100 mg/kg body weight), while the rats in the control group were injected with saline (n=5). The liver specimen was taken after one week. A portion of the largest hepatic lobe was extracted to quantify the LIC by inductively coupled plasma, and the remaining liver tissue was stored in 4% buffered paraformaldehyde for 24 h before MRI. Spin-lock preparation with RARE readout and 2D UTE readout pulses were developed to quantify R1ρ on a Bruker 11.7T MR system. Results: The mean R1ρ value of the rat liver with UTE-based R1ρ sequence was significantly higher compared to RARE-based R1ρ sequence (p<0.001). Spearman’s correlation analysis (two-tailed) indicated that the R1ρ values were significantly correlated with LIC for both UTE-R1ρ and RARE-R1ρ sequences (r = 0.727, P < 0.001, and r = 0.712, P < 0.001, respectively). Conclusion: The current study adds to evidence that there is a correlation between iron concentration and R1ρ. Moreover, UTE-based R1ρ sequence is more sensitive to the liver iron than the RARE-based R1ρ sequence. R1ρ might serve as a complementary imaging biomarker for liver iron overload quantification.

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R1ρ at high spin-lock frequency could be a complementary imaging biomarker for liver iron overload quantification

Cited by 2 publications

References 43 publications

Characterization and correction of the effects of hepatic iron on T_1ρ relaxation in the liver at 3.0T

Characterization and correction of the effects of hepatic iron on T_1ρ relaxation in the liver at 3.0T

Comparison of R1ρ Imaging Between Rapid Acquisition with Relaxation Enhancement (RARE) and Ultrashort TE (UTE) Sequence in the Assessment of Rat Liver Iron Overload at 11.7T

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R1ρ at high spin-lock frequency could be a complementary imaging biomarker for liver iron overload quantification

Cited by 2 publications

References 43 publications

Characterization and correction of the effects of hepatic iron on T1ρ relaxation in the liver at 3.0T

Characterization and correction of the effects of hepatic iron on T1ρ relaxation in the liver at 3.0T

Comparison of R1ρ Imaging Between Rapid Acquisition with Relaxation Enhancement (RARE) and Ultrashort TE (UTE) Sequence in the Assessment of Rat Liver Iron Overload at 11.7T

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Characterization and correction of the effects of hepatic iron on T_1ρ relaxation in the liver at 3.0T

Characterization and correction of the effects of hepatic iron on T_1ρ relaxation in the liver at 3.0T