R11 peptides can promote the molecular imaging of spherical nucleic acids for bladder cancer margin identification

Ma, Minghai; Zhang, Pu; Liang, Xiao; Cui, Daxiang; Shao, Qiuya; Zhang, Mengzhao; Yang, Tao; Wang, Lu; Zhang, Nan; Jing, Minxuan; Zhang, Lu; Dan, Weichao; Song, Rundong; Liu, Xi; Hao, Jiatao; Chen, Yuhang; Gu, Lijiang; Wang, Lei; Fan, Jinhai

doi:10.1007/s12274-021-3807-z

Cited by 15 publications

(15 citation statements)

References 46 publications

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“…However, the abundance of lysosomal enzymes tends to destroy the functional nucleic acids, which may significantly decrease detection efficiency [82]. Ma et al found that a poly(11)-arginine cell-penetrating peptide termed R11, which exhibited the highest uptake efficiency with regard to bladder cancer cells, can promote SNAs to escape from lysosomes and then enter the cytoplasm so that the SNAs can successfully achieve hybridization with the target and the rapid release of the fluorescence [83]. They modified the gold nanoparticles-molecular beacon (AuNP-MB) with R11 to detect survivin mRNA, which is abundant in bladder cancer and present in early-stage bladder cancer.…”

Section: Urinary Nano-cytologymentioning

confidence: 99%

Recent Progress in Nanomaterial-Based Biosensors and Theranostic Nanomedicine for Bladder Cancer

Song

Ding

et al. 2023

Biosensors

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Bladder cancer (BCa) is one of the most expensive and common malignancies in the urinary system due to its high progression and recurrence rate. Although there are various methods, including cystoscopy, biopsy, and cytology, that have become the standard diagnosis methods for BCa, their intrinsic invasive and inaccurate properties need to be overcome. The novel urine cancer biomarkers are assisted by nanomaterials-based biosensors, such as field-effect transistors (FETs) with high sensitivity and specificity, which may provide solutions to these problems. In addition, nanomaterials can be applied for the advancement of next-generation optical imaging techniques and the contrast agents of conventional techniques; for example, magnetic resonance imaging (MRI) for the diagnosis of BCa. Regarding BCa therapy, nanocarriers, including mucoadhesive nanoparticles and other polymeric nanoparticles, successfully overcome the disadvantages of conventional intravesical instillation and improve the efficacy and safety of intravesical chemotherapy for BCa. Aside from chemotherapy, nanomedicine-based novel therapies, including photodynamic therapy (PDT), photothermal therapy (PTT), chemodynamic therapy (CDT), sonodynamic therapy (SDT), and combination therapy, have afforded us new ways to provide BC therapy and hope, which can be translated into the clinic. In addition, nanomotors and the nanomaterials-based solid tumor disassociation strategy provide new ideas for future research. Here, the advances in BCa diagnosis and therapy mentioned above are reviewed in this paper.

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Section: Urinary Nano-cytologymentioning

confidence: 99%

Recent Progress in Nanomaterial-Based Biosensors and Theranostic Nanomedicine for Bladder Cancer

Song

Ding

et al. 2023

Biosensors

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“…Thus, AuNP-MB@R11 can be regarded as an intraoperative molecular imaging technique to achieve complete tumor resection and improve recurrence-free survival. [64] In addition, chitosan-based nanomedicine that delivers gambogic acid prodrug in response to GSH and ROS signaling has also been reported. [66] Cationic chitosan is a well-known mucoadhesive biomolecule that significantly enhances drug adhesion to and penetration of the bladder wall.…”

Section: Synthetic Nanomaterials Against Bcmentioning

confidence: 99%

“…[63] For sensitive detection of BC margins in surgery, nanoprobes (AuNP-MB@R11) containing molecular beacon (MB) corresponding to survivin and R11 peptide-linked spherical nucleic acids (SNAs) were synthesized. [64] Researchers first constructed SNAs composed of AuNPs and MB to quantify survivin mRNA. [65] Then, due to the super BC targeting and cellular uptake potency of the poly (11)-arginine cell-penetrating peptide (R11), they further attached R11 peptides to SNAs to form AuNP-MB@R11 NPs.…”

Section: Synthetic Nanomaterials Against Bcmentioning

confidence: 99%

“…For instance, survivin , a member of the apoptosis inhibitory protein family, can serve as a specific marker for BC [63] . For sensitive detection of BC margins in surgery, nanoprobes (AuNP-MB@R11) containing molecular beacon (MB) corresponding to survivin and R11 peptide-linked spherical nucleic acids (SNAs) were synthesized [64] . Researchers first constructed SNAs composed of AuNPs and MB to quantify survivin mRNA [65] .…”

Section: Nanomaterials For Improving Recognition Specificity and Kill...mentioning

confidence: 99%

“…A cancerous fluorescence margin is observed. Thus, AuNP-MB@R11 can be regarded as an intraoperative molecular imaging technique to achieve complete tumor resection and improve recurrence-free survival [64] . In addition, chitosan-based nanomedicine that delivers gambogic acid prodrug in response to GSH and ROS signaling has also been reported [66] .…”

Section: Nanomaterials For Improving Recognition Specificity and Kill...mentioning

confidence: 99%

See 2 more Smart Citations

Application of synthetic biology in bladder cancer

Ding

Lin

Qin

et al. 2022

Chinese Medical Journal

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Bladder cancer (BC) is the most common malignant tumor of the genitourinary system. The age of individuals diagnosed with BC tends to decrease in recent years. A variety of standard therapeutic options are available for the clinical management of BC, but limitations exist. It is difficult to surgically eliminate small lesions, while radiation and chemotherapy damage normal tissues, leading to severe side effects. Therefore, new approaches are required to improve the efficacy and specificity of BC treatment. Synthetic biology is a field emerging in the last decade that refers to biological elements, devices, and materials that are artificially synthesized according to users’ needs. In this review, we discuss how to utilize genetic elements to regulate BC-related gene expression periodically and quantitatively to inhibit the initiation and progression of BC. In addition, the design and construction of gene circuits to distinguish cancer cells from normal cells to kill the former but spare the latter are elaborated. Then, we introduce the development of genetically modified T cells for targeted attacks on BC. Finally, synthetic nanomaterials specializing in detecting and killing BC cells are detailed. This review aims to describe the innovative details of the clinical diagnosis and treatment of BC from the perspective of synthetic biology.

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Design of Near Infrared Light‐Powered Copper Phyllosilicate Nanomotors for Cuproptosis‐Based Synergistic Cancer Therapy

Song,

Zhan,

Zhou

2024

Adv Funct Materials

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Cuproptosis, a newly discovered cell death pathway, has shown great potential in cancer treatment. Herein, near‐infrared (NIR) light‐driven nanomotors (CuSiO3@Au‐Pd NMs) are designed for cuproptosis‐assisted synergistic therapy with autonomous mobility and improved cellular uptake and tumor penetration. Specifically, the released Cu2+ ions from CuSiO3@Au‐Pd NMs can induce the Fenton‐like reaction, leading to the generation of hydroxyl radicals (·OH), accompanied by the depletion of glutathione within the MCF‐7 cells. Additionally, the designed CuSiO3@Au‐Pd NMs also exhibit excellent photothermal effects, which can further promote the production of ·OH, resulting in intensified oxidative stress and cellular apoptosis. Moreover, the enhanced tumor permeation efficiency and cellular uptake of CuSiO3@Au‐Pd NMs via autonomous movement under self‐thermophoretic forces are proved using 2D cellular experiments and 3D multicellular tumor spheroids. The resultant intracellular accumulation of Cu2+ can induce the oligomerization of lipoylated proteins, leading to cuproptosis, along with the mitochondrial dysfunction pathway. More importantly, both in vitro and in vivo experiments show that CuSiO3@Au‐Pd NMs could penetrate deeply into tumors and exhibit great anticancer efficacy through multimodal therapeutic methods. These findings manifest promising potentials of NIR‐powered Cu‐based NMs with high maneuverability for future smart and synergistic cancer therapy.

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R11 peptides can promote the molecular imaging of spherical nucleic acids for bladder cancer margin identification

Cited by 15 publications

References 46 publications

Recent Progress in Nanomaterial-Based Biosensors and Theranostic Nanomedicine for Bladder Cancer

Recent Progress in Nanomaterial-Based Biosensors and Theranostic Nanomedicine for Bladder Cancer

Application of synthetic biology in bladder cancer

Design of Near Infrared Light‐Powered Copper Phyllosilicate Nanomotors for Cuproptosis‐Based Synergistic Cancer Therapy

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