(R)-α-Methylhistamine augments neural, cholinergic bronchospasm in guinea pigs by histamine H1 receptor activation

Hey, John A.; Prado, M. del; Egan, Robert W.; Kreutner, William; Chapman, Richard W.

doi:10.1016/0014-2999(92)90401-o

Cited by 27 publications

(14 citation statements)

References 23 publications

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“…These hypertensive events are mediated by activation of bulbospinal I v 0.01 sympathetic pathways as they are blocked with o-adrenoceptor antagonists, ganglionic blockers such as hexamethonium and spinal cord transection with lignocaine (Hey et al, 1990b). Our results in guinea-pigs indicate that (R)-x-methylhistamine inhibits the hypertension produced by electrical stimulation of the dorsal medulla (Hey et al, 1992) and that the effects of (R)-x-methylhistamine are not blocked by H1or H2-receptor antagonists. On the other hand, thioperamide, which is a selective H3-antagonist (Arrang et al, 1987) blocks the effect of (R)-a-methylhistamine, implicating the H3receptor.…”

Section: Discussionmentioning

confidence: 62%

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Inhibition of sympathetic hypertensive responses in the guinea‐pig by prejunctional histamine H₃‐receptors

Hey¹,

Prado²,

Egan³

et al. 1992

British J Pharmacology

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1 The effect of (R)-a-methylhistamine, a selective H3-histamine receptor agonist, was examined on the neurogenic hypertension and tachycardia that is induced by stimulation of areas in the medulla oblongata of guinea-pigs. Electrical medullary stimulation (32 Hz, 3-5 s trains, 0.5-1.0 ms square pulse, 25-400 juA) produced intensity-dependent increases in blood pressure and a more variable tachycardia.2 (R)-ac-methylhistamine inhibited the hypertension and tachycardia due to submaximal CNS stimulation. The inhibition of hypertension by (R)-x-methylhistamine was dose-dependent (1O-300 tg kg-', i.v.) and was not seen at high intensities of stimulation. 3 (R)-o-methylhistamine (300 ptg kg-', i.v.) did not attenuate the pressor response to adrenaline (1 and 3 fLg kg-', i.v.), indicating that the effect of (R)-x-methylhistamine was not mediated by a postjunctional action on smooth muscle. 4 The inhibition of CNS-induced hypertension by (R)-x-methylhistamine (300 yg kg-', i.v.) was blocked by the H3 antagonists, thioperamide (ID50 = 0.39 mg kg-', iv.), impromidine (ID50 = 0.22 mg kg-, i.v.) and burimamide (ID50 = 6 mg kg-', i.v.). The rank order potency of these antagonists is consistent with activity at the H3B receptor subtype. Chlorpheniramine (30 ptg kg-', i.v.) and cimetidine (3 mg kg-', i.v.) did not antagonize the inhibition of CNS-hypertension by (R)-a-methylhistamine. 5 These results suggest that (R)-a-methylhistamine inhibits sympathetic hypertensive responses in guinea-pigs by activation of prejunctional H3-receptors, possibly located on postganglionic nerve terminals. Furthermore, on the basis of the rank order potency to different H3-antagonists, it appears that the H3B-receptor subtype is involved with H3-receptor responses on vascular sympathetic nerves.

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Section: Discussionmentioning

confidence: 62%

“…Under these conditions, 300 jLg kg-' of (R)-a-methylhistamine produced a maximal inhibition of 48 ± 10%. Higher doses of (R)-o-methylhistamine could not be tested, because they cause histamine H,-receptor-mediated responses (Hey et al, 1992). The ED50 (dose producing 50% of maximal inhibition) for (R)-a-methylhistamine was 100 pg kg-', i.v.…”

Section: Resultsmentioning

confidence: 99%

Inhibition of sympathetic hypertensive responses in the guinea‐pig by prejunctional histamine H₃‐receptors

Hey¹,

Prado²,

Egan³

et al. 1992

British J Pharmacology

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“…This activity should be considered in future when these drugs are used. Especially under in vivo conditions this activity may become apparent, since under these conditions it has already been shown, for example that a weak interaction of the H3 receptor agonist (R)-a-methylhistamine with the HI-receptor (Hey et al, 1992) and a2-adrenoceptor must be considered (Malinowska & Schlicker, 1993;Schlicker et al, 1994;Timmerman et al, 1995). Moreover, in a preliminary study on the cardiovascular effects of several H3 receptor agonists in the rat, 5-HT3 receptor effects for imetit were noticed in vivo (Timmerman et al, 1995).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the receptor selectivity of the H₃ receptor antagonists, iodophenpropit and thioperamide: an interaction with the 5‐HT₃ receptor revealed

Leurs

Tulp

Menge

et al. 1995

British J Pharmacology

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1 In the present study we evaluated the receptor selectivity of the potent histamine H3 receptor antagonist, iodophenpropit (IPP) in comparison with the prototype antagonist, thioperamide. 2 IPP proved to be a potent competitive H3 receptor antagonist as measured against (R)-amethylhistamine-induced inhibition of electrically-evoked contractions of the guinea-pig jejunum (pA2=9.12+0.06, Schild slope: 1.0 0.1, n=8). In the same assay, thioperamide was slightly less potent (pA2 = 8.9 ± 0.2). histamine or the H3 receptor agonist, (R)-a-methylhistamine showed no affinity for the 5-HT3 receptor. 7 In the guinea-pig isolated ileum, imetit evoked concentration-dependent contractions, resulting in a pD2 value of 4.72 ± 0.03 (n = 9). The contractions were antagonized by ondansetron, yielding a pA2 value of 7.1 ± 0.1 (n = 9). Similarly ondansetron antagonized the contractions evoked by the 5-HT3 receptor agonist, 2-methyl-5-HT with a pA2 value of 7.3 ± 0.1 (n = 4). IPP and thioperamide did not mimic 2-methyl-5-HT but non-competitively inhibited the 2-methyl-5-HT-induced contractions of this preparation. 8 In an in vivo model for 5-HT3 activity, the Von Bezold Jarisch reflex, thioperamide showed antagonism in low dosages, which correlated well with the affinity for the 5-HT3 receptor site. Yet, at higher dosages no further 5-HT3 receptor antagonism was observed. For IPP no 5-HT3 receptor activity could be observed in vivo. 9 In the present study we showed that many H3 receptor compounds, that are regarded as highly selective (including the prototype drug, thioperamide), also interact with the 5-HT3 receptor, albeit at higher drug concentrations.

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“…In guinea‐pigs, H 3 R is present on the vagus nerve, which modulates cholinergic neurotransmission in the airways [11]. An extensive body of evidence indicates that H 3 R modulates sympathetic and parasympathetic function throughout the peripheral autonomic system [12–15]. Previous findings suggest that H 3 R plays a role in AR, and that expression of H 3 R increases during AR.…”

Section: Introductionmentioning

confidence: 99%

Localization and function of histamine H₃ receptor in the nasal mucosa

Suzuki

Takeuchi

Majima

2008

Clin Experimental Allergy

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(R)-α-Methylhistamine augments neural, cholinergic bronchospasm in guinea pigs by histamine H1 receptor activation

Cited by 27 publications

References 23 publications

Inhibition of sympathetic hypertensive responses in the guinea‐pig by prejunctional histamine H₃‐receptors

Inhibition of sympathetic hypertensive responses in the guinea‐pig by prejunctional histamine H₃‐receptors

Evaluation of the receptor selectivity of the H₃ receptor antagonists, iodophenpropit and thioperamide: an interaction with the 5‐HT₃ receptor revealed

Localization and function of histamine H₃ receptor in the nasal mucosa

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(R)-α-Methylhistamine augments neural, cholinergic bronchospasm in guinea pigs by histamine H1 receptor activation

Cited by 27 publications

References 23 publications

Inhibition of sympathetic hypertensive responses in the guinea‐pig by prejunctional histamine H3‐receptors

Inhibition of sympathetic hypertensive responses in the guinea‐pig by prejunctional histamine H3‐receptors

Evaluation of the receptor selectivity of the H3 receptor antagonists, iodophenpropit and thioperamide: an interaction with the 5‐HT3 receptor revealed

Localization and function of histamine H3 receptor in the nasal mucosa

Contact Info

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Inhibition of sympathetic hypertensive responses in the guinea‐pig by prejunctional histamine H₃‐receptors

Inhibition of sympathetic hypertensive responses in the guinea‐pig by prejunctional histamine H₃‐receptors

Evaluation of the receptor selectivity of the H₃ receptor antagonists, iodophenpropit and thioperamide: an interaction with the 5‐HT₃ receptor revealed

Localization and function of histamine H₃ receptor in the nasal mucosa