2020
DOI: 10.21203/rs.2.18790/v2
|View full text |Cite
Preprint
|
Sign up to set email alerts
|

R-spondin 2 mediates neutrophil egress into the alveolar space through increased lung permeability.

Abstract: Objective R-spondin 2 (RSPO2) is required for lung morphogenesis, activates Wnt signaling, and is upregulated in idiopathic lung fibrosis. Our objective was to investigate whether RSPO2 is similarly important in homeostasis of the adult lung. While investigating the characteristics of bronchoalveolar lavage in RSPO2-deficient (RSPO2-/-) mice, we observed unexpected changes in neutrophil homeostasis and vascular permeability when compared to control (RSPO2+/+) mice at baseline. Here we quantify these observatio… Show more

Help me understand this report
View published versions

Search citation statements

Order By: Relevance

Paper Sections

Select...
2

Citation Types

1
0
1

Year Published

2021
2021
2021
2021

Publication Types

Select...
1
1

Relationship

0
2

Authors

Journals

citations
Cited by 2 publications
(2 citation statements)
references
References 6 publications
1
0
1
Order By: Relevance
“…This body of work supports vaginal epithelial cells to be the key source of IL-33-mediated type 2 immunity in the FGT during co-infection. Recent studies have identified myeloid sources of IL-33 to play roles in downregulating mucosal inflammation (Hung et al, 2020a(Hung et al, , 2020bJackson et al, 2020;Sell et al, 2020). The findings we present here do not currently suggest a role for cells other than epithelial cells as a contributing source of IL-33.…”
Section: Discussioncontrasting
confidence: 73%
“…This body of work supports vaginal epithelial cells to be the key source of IL-33-mediated type 2 immunity in the FGT during co-infection. Recent studies have identified myeloid sources of IL-33 to play roles in downregulating mucosal inflammation (Hung et al, 2020a(Hung et al, , 2020bJackson et al, 2020;Sell et al, 2020). The findings we present here do not currently suggest a role for cells other than epithelial cells as a contributing source of IL-33.…”
Section: Discussioncontrasting
confidence: 73%
“…recently examined the consequences of Rspo2 conditional deletion in adult mice. They reported that Rspo2 loss caused lung neutrophilia via a disrupted lung endothelial barrier (68). While there are no variants within this gene, we noted multiple noncoding variants within the in/near the gene, and its function is in alignment with features of the pathology caused by O3 exposure.…”
Section: Discussionsupporting
confidence: 47%