“…Following the general procedure for S N Ar displacement on 2,5-dichloro- N -arylpyrimidin-4-amines, 12d (92 mg, 0.3 mmol) and 21e (0.1 g, 0.3 mmol) gave 26 (76 mg, 24% yield) as a tan solid. Mp 196–197 °C; LC/MS (ESI + ) m / z 630.18 (M + H) + ; 1 H NMR (400 MHz, CDCl 3 ) δ 9.42 (s, 1H), 8.57 (d, J = 8.3 Hz, 1H), 8.16 (s, 1H), 8.02 (d, J = 8.1 Hz, 1H), 7.89 (d, J = 8.1 Hz, 1H), 7.63 (t, J = 7.8 Hz, 1H), 7.52 (s, 1H), 7.31–7.25 (m, 2H), 6.92–6.87 (m, 1H), 3.74 (s, 3H), 3.69 (br t, J = 5.2 Hz, 2H), 3.26 (br dd, J = 14.1, 6.8 Hz, 1H), 2.95–2.82 (br s, 4H), 2.76 (s, 6H), 2.75–2.61 (m, 8H), 2.54–2.37 (m, 2H), 2.20–2.10 (m, 2H), 1.82 (br s, 1H), 1.45–1.30 (m, 1H).…”