R

A Concise Construction of Polycyclic Quinolines via Annulation of ω-Cyano-1-alkynes with Diaryliodonium Salts

“…Polycyclic quinolines are privileged scaffolds in various bioactive natural products (especially in alkaloids) and many synthetic therapeutic agents . For instance, tacrine, a tricyclic quinoline (under the trade name of Cognex, Figure ), was the first approved drug for the treatment of Alzheimer’s disease as a centrally acting anticholinesterase and indirect cholinergic agonist .…”

A New and Improved Process for Celiprolol Hydrochloride

“…Drugs belonging to the class of aryloxypropanolamine ( 1 ) are useful β-blockers . A large number of β-blockers are currently marketed and include propranolol, atenolol, metoprolol, nadolol, cervidolol, celiprolol etc.…”

Rh-Catalyzed Annulation of Enaminones with Maleimides for Functionalized Aza-spiro α-Tetralones and Benzo[e]isoindoles via C–H Activation/C═C Bond Cleavage

“…The α-tetralones and spiro α-tetralones are abundant moieties in naturally occurring and biologically active materials (Figure A) . As a result, they are often used as building blocks in the preparation of natural products, medicines, agrochemicals, and dyes .…”