2018
DOI: 10.1016/j.jmr.2018.03.010
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R 1 dispersion contrast at high field with fast field-cycling MRI

Abstract: Contrast agents with a strong R dispersion have been shown to be effective in generating target-specific contrast in MRI. The utilization of this R field dependence requires the adaptation of an MRI scanner for fast field-cycling (FFC). Here, we present the first implementation and validation of FFC-MRI at a clinical field strength of 3 T. A field-cycling range of ±100 mT around the nominal B field was realized by inserting an additional insert coil into an otherwise conventional MRI system. System validation … Show more

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Cited by 16 publications
(38 citation statements)
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“…[13] The hydrophobic moieties of the Gd 3 + complex promotei nteraction with HSA, which generate af ield-dependent relaxometricr esponse to Zn 2 + at physiological HSA concentrationa s illustrated in Figure 2. For FFC-MRI, the hardware was realized by meanso fa na dditional B 0 insert coil synchronized with ac linical MRI system with amain magnetic field strength B 0 of 2.89 T. [14] The field-cycling hardware is capable of generating offset fields DB 0 of AE 100 mT within am inimum ramp time of 1ms. The Zn 2 + response is maximal at 0.7-1 Tw ith ar elaxivity increase of about 25 % upon Zn 2 + -binding.…”
mentioning
confidence: 99%
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“…[13] The hydrophobic moieties of the Gd 3 + complex promotei nteraction with HSA, which generate af ield-dependent relaxometricr esponse to Zn 2 + at physiological HSA concentrationa s illustrated in Figure 2. For FFC-MRI, the hardware was realized by meanso fa na dditional B 0 insert coil synchronized with ac linical MRI system with amain magnetic field strength B 0 of 2.89 T. [14] The field-cycling hardware is capable of generating offset fields DB 0 of AE 100 mT within am inimum ramp time of 1ms. The Zn 2 + response is maximal at 0.7-1 Tw ith ar elaxivity increase of about 25 % upon Zn 2 + -binding.…”
mentioning
confidence: 99%
“…In contrast, at 9.4 T, aroughly30% relaxivity decrease is obtained, while around 3T ,t he response vanishes as the two NMRD profiles crosse ach other.I na ccordance with theser esults, no visible difference in R 1 can be observed in response to increasingZ n 2 + concentration in solutionso f GdL and HSA, by using standard MRI methods at 3T (Figure 3b). For FFC-MRI, the hardware was realized by meanso fa na dditional B 0 insert coil synchronized with ac linical MRI system with amain magnetic field strength B 0 of 2.89 T. [14] The field-cycling hardware is capable of generating offset fields DB 0 of AE 100 mT within am inimum ramp time of 1ms. Imagesw ere acquired at three different evolution fields (2.79, 2.89, and 2.99 T) using as aturation prepared spin echo sequence, where B 0 was rampedt ot he desired field-shift for ad uration T evol between the preparation pulse and image acquisition.…”
mentioning
confidence: 99%
“…When it comes to an application of the presented method, we would like to mention that the tool can support ongoing research on MRI contrast agents based on the QRE effect [2,15,25] which is especially suitable for FFC-MRI systems [24]. Of course, the requirements and conditions for a particle acting as MRI contrast agent in biological tissue are rather complex and not straightforward to fulfil.…”
Section: Resultsmentioning
confidence: 99%
“…Lurie et al [20] have utilised this effect for magnetic resonance imaging (MRI) and could demonstrate a contrast enhancement in T 1 = 1/R 1 weighted images using a special field cycling MRI systems at low magnetic field strengths ( < 200 mT). Field cycling MRI has also been successfully demonstrated at clinical field strengths of 1.5 T [21-23] and 3 T [24]. Recently, strong and pronounced QRE peaks have been observed in NMRD measurements of different Bi-aryl compounds [2].…”
Section: Introductionmentioning
confidence: 99%
“…medicine if combined with MRI and much efforts are dedicated to create FFC-MRI scanners [11][12][13][14][15].…”
Section: Introductionmentioning
confidence: 99%