Quorum sensing inhibitors as antipathogens: biotechnological applications

Kalia, Vipin Chandra; Patel, Sanjay; Kang, Yun Chan; Lee, Jung-Kul

doi:10.1016/j.biotechadv.2018.11.006

Cited by 241 publications

(141 citation statements)

References 364 publications

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“…It was shown that caffeine demonstrates anti-QS properties against P. aeruginosa inhibiting the production of AHL (N-acyl homoserine lactone) signalling molecules [149,150]. Similar observations have also been published for other pathogens [141,[151][152][153][154]. Two major mechanisms of QS-inhibition by SMoPs are assumed: the first one consists of the down-regulation of QS genes, resulting in a lower expression of signal molecules, while the second mechanism includes interaction between SMoPs and a QS signal molecule resulting in the inactivation of quorum mediators and a decreasing intensity and effectiveness of cell-to-cell interaction [141,151].…”

Section: Disrupting the Biofilmssupporting

confidence: 68%

Plant Secondary Metabolites in the Battle of Drugs and Drug-Resistant Bacteria: New Heroes or Worse Clones of Antibiotics?

et al. 2020

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Infectious diseases that are caused by bacteria are an important cause of mortality and morbidity in all regions of the world. Bacterial drug resistance has grown in the last decades, but the rate of discovery of new antibiotics has steadily decreased. Therefore, the search for new effective antibacterial agents has become a top priority. The plant kingdom seems to be a deep well for searching for novel antimicrobial agents. This is due to the many attractive features of plants: they are readily available and cheap, extracts or compounds from plant sources often demonstrate high-level activity against pathogens, and they rarely have severe side effects. The huge variety of plant-derived compounds provides very diverse chemical structures that may supply both the novel mechanisms of antimicrobial action and provide us with new targets within the bacterial cell. In addition, the rapid development of modern biotechnologies opens up the way for obtaining bioactive compounds in environmentally friendly and low-toxic conditions. In this short review, we ask the question: do antibacterial agents derived from plants have a chance to become a panacea against infectious diseases in the “post-antibiotics era”.

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Section: Disrupting the Biofilmssupporting

confidence: 68%

Plant Secondary Metabolites in the Battle of Drugs and Drug-Resistant Bacteria: New Heroes or Worse Clones of Antibiotics?

et al. 2020

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“…The biotechnological applications of quorum sensing inhibitors (quorum quenchers) have been frequently reported in recent publications, and the usage of different quorum quenchers has been described so far (Kalia et al 2019). They may constitute products of bacteria (e.g., norspermidine), plants (secondary metabolites, e.g., catechins from green tea leaves Camellia sinensis), and animals (enzymes such as acylases, lactonases, and oxidoreductaes isolated from Mus musculus or Danio rerio (Kalia 2013;Nesse et al 2015;Yin et al 2015;Qu et al 2016).…”

Section: Applications Of Qqmentioning

confidence: 99%

Prevention of biofilm formation by quorum quenching

Paluch

Rewak‐Soroczyńska

Jędrusik

et al. 2020

Appl Microbiol Biotechnol

277

151

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Quorum sensing (QS) is a mechanism that enables microbial communication. It is based on the constant secretion of signaling molecules to the environment. The main role of QS is the regulation of vital processes in the cell such as virulence factor production or biofilm formation. Due to still growing bacterial resistance to antibiotics that have been overused, it is necessary to search for alternative antimicrobial therapies. One of them is quorum quenching (QQ) that disrupts microbial communication. QQ-driving molecules can decrease or even completely inhibit the production of virulence factors (including biofilm formation). There are few QQ strategies that comprise the use of the structural analogues of QS receptor autoinductors (AI). They may be found in nature or be designed and synthesized via chemical engineering. Many of the characterized QQ molecules are enzymes with the ability to degrade signaling molecules. They can also impede cellular signaling cascades. There are different techniques used for testing QS/QQ, including chromatography-mass spectroscopy, bioluminescence, chemiluminescence, fluorescence, electrochemistry, and colorimetry. They all enable qualitative and quantitative measurements of QS/QQ molecules. This article gathers the information about the mechanisms of QS and QQ, and their effect on microbial biofilm formation. Basic methods used to study QS/QQ, as well as the medical and biotechnological applications of QQ, are also described. Basis research methods are also described as well as medical and biotechnological application.

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“…QS inhibitors (QSIs) can inhibit the QS mechanism and attenuate virulence without influencing bacterial growth. Thus, QSIs can be used to disarm pathogens in the host and are not easy to cause bacterial resistance compared to conventional antibiotics [4,5]. The search for efficient QSIs is supposed to be an effective method to solve problems of bacterial infection and antibiotic resistance.…”

Section: Introductionmentioning

confidence: 99%

“…The EtOAc extract of the fermentation broth of this fungus showed obvious QS inhibitory activity against Chromobacterium violaceum CV026. Subsequent chemical investigation on the EtOAc extract of the fermentation broth had led to the isolation of five new compounds, named altertoxins VIII-XII (1)(2)(3)(4)(5), as well as a known one, cladosporol I (6) [10] (Figure 1). All of the new compounds showed obvious QS inhibitory activities.…”

Section: Introductionmentioning

confidence: 99%

Altertoxins with Quorum Sensing Inhibitory Activities from The Marine-Derived Fungus Cladosporium sp. KFD33

et al. 2020

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Five new perylenequinone derivatives, altertoxins VIII–XII (1–5), as well as one known compound cladosporol I (6), were isolated from the fermentation broth of the marine-derived fungus Cladosporium sp. KFD33 from a blood cockle from Haikou Bay, China. Their structures were determined based on spectroscopic methods and ECD spectra analysis along with quantum ECD calculations. Compounds 1–6 exhibited quorum sensing inhibitory activities against Chromobacterium violaceum CV026 with MIC values of 30, 30, 20, 30, 20 and 30 μg/well, respectively.

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Quorum sensing inhibitors as antipathogens: biotechnological applications

Cited by 241 publications

References 364 publications

Plant Secondary Metabolites in the Battle of Drugs and Drug-Resistant Bacteria: New Heroes or Worse Clones of Antibiotics?

Plant Secondary Metabolites in the Battle of Drugs and Drug-Resistant Bacteria: New Heroes or Worse Clones of Antibiotics?

Prevention of biofilm formation by quorum quenching

Altertoxins with Quorum Sensing Inhibitory Activities from The Marine-Derived Fungus Cladosporium sp. KFD33

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