Quorum sensing dependent phenotypes and their molecular mechanisms inCampylobacterales

Abstract

Quorum sensing comprises the mechanism of communication between numerous bacteria via small signalling molecules, termed autoinducers (AI). Using quorum sensing, bacteria can regulate the expression of multiple genes involved in virulence, toxin production, motility, chemotaxis and biofilm formation, thus contributing to adaptation as well as colonisation. The current understanding of the role of quorum sensing in the lifecycle of Campylobacterales is still incomplete. Campylobacterales belong to the class of Epsilonproteobacteria representing a physiologically and ecologically diverse group of bacteria that are rather distinct from the more commonly studied Proteobacteria, such as Escherichia and Salmonella. This review summarises the recent knowledge on distribution and production of AI molecules, as well as possible quorum sensing dependent regulation in the mostly investigated species within the Campylobacterales group: Campylobacter jejuni and Helicobacter pylori.

Enhanced biofilm formation and multi‐host transmission evolve from divergent genetic backgrounds in Campylobacter jejuni

“…A total of 605 words mapped to genes that have previously been shown to have a functional association with increased biofilm production, such as motility (Svensson et al ., ), chemotaxis (Golz et al ., ), capsule production (Malde et al ., ) and protein glycosylation (Joshua et al ., ; Guerry, ) (http://onlinelibrary.wiley.com/doi/10.1111/1462-2920.13051/suppinfo; highlighted in Fig. B).…”

Mechanisms of Bacterial Tolerance and Persistence in the Gastrointestinal and Respiratory Environments

“…This process affects bacterial populations and determines the expression of genes regulating virulence, toxin production, motility, chemotaxis, biofilm production, and bacterial competition (secretion systems [T3SS and T6SS]) ( Fig. 2), which may contribute to bacterial adaptation and colonization (218). In this review, we consider proteins from the QS system and secretion systems (T3SS and T6SS) due to their association with the development of persister cells, as described for pathogens such as P. aeruginosa and Mycobacterium spp.…”

Resveratrol inclusion complexes: Antibacterial and anti-biofilm activity against Campylobacter spp. and Arcobacter butzleri

“…Nonetheless, the anti-biofilm activity of resveratrol against several pathogens has already been described, being suggested that this activity may be related to the regulation of biofilm-related genes such as adhesion, motility or even QS genes (Augustine, Goel, Sivakumar, Kumar, & Thomas, 2014;Lee, Kim, Ryu, Cho, & Lee, 2014a;Lee, Lee, Ryu, Cho, & Lee, 2014b). So, the antibiofilm activity of the IC could be explained by the effect of the active compound, resveratrol, in genes associated with biofilms formation, and the effect on the pre-establish biofilm could be mainly due to the effect on QS, since this process has been documented to play a role in the formation and maintenance of Campylobacter biofilms (Gölz, Sharbati, Backert, & Alter, 2012;Reeser et al, 2007).…”