2000
DOI: 10.1128/jb.182.4.1080-1088.2000
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Quorum Sensing but Not Autoinduction of Ti Plasmid Conjugal Transfer Requires Control by the Opine Regulon and the Antiactivator TraM

Abstract: Conjugal transfer of the Ti plasmids from Agrobacterium tumefaciens is controlled by autoinduction via the transcriptional activator TraR and the acyl-homoserine lactone ligand, Agrobacterium autoinducer (AAI). This control process is itself regulated by opines, which are small carbon compounds produced by the crown gall tumors that are induced by the bacteria. Opines control autoinduction by regulating the expression of traR. Transfer of pTiC58 from donors grown with agrocinopines A and B, the conjugal opines… Show more

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Cited by 70 publications
(76 citation statements)
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“…In previous studies, we showed that responsiveness to the quormone is delayed for several hours following opine induction (25). While we postulated that this delay is due to TraM, we could not test the hypothesis, since traM mutants are constitutive for transfer.…”
mentioning
confidence: 56%
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“…In previous studies, we showed that responsiveness to the quormone is delayed for several hours following opine induction (25). While we postulated that this delay is due to TraM, we could not test the hypothesis, since traM mutants are constitutive for transfer.…”
mentioning
confidence: 56%
“…Finally, these results strongly suggest that TraM in its interaction with TraR establishes the minimum concentration of the acyl-HSL required to fully induce the system. That donors harboring pCMA1⌬traI (accR ϩ traM), which expresses only basal levels of TraR (25), are essentially as sensitive to quormone as those harboring pKMA1⌬traI (accR traM), which constitutively expresses traR (compare Fig. 2A and C), suggests that sensitivity to signal is not a function of the amount of TraR produced but rather a function of the amount of available TraR, that is, the amount of activator not complexed with TraM.…”
Section: Vol 190 2008 Induction and Decay Of Quorum-regulated Conjumentioning
confidence: 94%
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