Quorum sensing: A nobel target for antibacterial agents

Asif, Mohammad; Acharya, Mrityunjoy

doi:10.4103/2231-0770.110743

Cited by 6 publications

(1 citation statement)

References 29 publications

(45 reference statements)

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“…A novel proteomic approach was utilised here to shed light on an alternative mechanism of action-the disruption of iron metabolism and attenuation of virulence through reduced QS and swarming ability. There is ample evidence of the physiological links between iron and QS pathways in bacteria [118][119][120][121] and the exploitation of QS as a drug target is well established [122][123][124][125]. The development of novel or re-purposed compounds are imperative to combat AMR in clinically relevant bacteria and the results presented here indicate that GaM is active in vitro and in vivo for the treatment of recalcitrant P. aeruginosa infection.…”

Section: Discussionmentioning

confidence: 83%

Quantitative proteomic reveals gallium maltolate induces an iron-limited stress response and reduced quorum-sensing in Pseudomonas aeruginosa

Piatek

Griffith²,

Kavanagh

2020

J Biol Inorg Chem

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Gallium-based drugs have been repurposed as antibacterial therapeutic candidates and have shown significant potential as an alternative treatment option against drug resistant pathogens. The activity of gallium (Ga 3+ ) is a result of its chemical similarity to ferric iron (Fe 3+ ) and substitution into iron-dependent pathways. Ga 3+ is redox inactive in typical physiological environments and therefore perturbs iron metabolism vital for bacterial growth. Gallium maltolate (GaM) is a wellknown water-soluble formulation of gallium, consisting of a central gallium cation coordinated to three maltolate ligands, [Ga(Maltol -1H ) 3 ]. This study implemented a label-free quantitative proteomic approach to observe the effect of GaM on the bacterial pathogen, Pseudomonas aeruginosa. The replacement of iron for gallium mimics an iron-limitation response, as shown by increased abundance of proteins associated with iron acquisition and storage. A decreased abundance of proteins associated with quorum-sensing and swarming motility was also identified. These processes are a fundamental component of bacterial virulence and dissemination and hence suggest a potential role for GaM in the treatment of P. aeruginosa infection.

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Section: Discussionmentioning

confidence: 83%

Quantitative proteomic reveals gallium maltolate induces an iron-limited stress response and reduced quorum-sensing in Pseudomonas aeruginosa

Piatek

Griffith²,

Kavanagh

2020

J Biol Inorg Chem

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Anti-quorum Sensing Properties of Mushrooms

Bedlovičová

Strapáč

2022

Promising Antimicrobials From Natural Products

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The LuxS/AI-2 system of Streptococcus suis

Wang

Sun

et al. 2018

Appl Microbiol Biotechnol

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Quorum sensing (QS) is an important protective mechanism that allows bacteria to adapt to its environment. A limited number of signal molecules play the key role of transmitting information in this mechanism. Signals are transmitted between individual bacterium through QS systems, resulting in the expression of specific genes. QS plays an important role in a variety of bacterial processes, including drug resistance, biofilm formation, motility, adherence, and virulence. Most Gram-positive and Gram-negative bacteria possess QS systems, mainly the LuxS/AI-2-mediated QS system. Evidence has been brought that LuxS/AI-2 system controls major virulence determinants in Streptococcus suis and, as such, the ability of this bacterial species to cause infections in humans and pigs. Understanding the S. suis LuxS/AI-2 system may open up novel avenues for decreasing the drug resistance and infectivity of S. suis. This article focuses on the progress made to date on the S. suis LuxS/AI-2-mediated QS system.

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Quorum sensing: A nobel target for antibacterial agents

Cited by 6 publications

References 29 publications

Quantitative proteomic reveals gallium maltolate induces an iron-limited stress response and reduced quorum-sensing in Pseudomonas aeruginosa

Quantitative proteomic reveals gallium maltolate induces an iron-limited stress response and reduced quorum-sensing in Pseudomonas aeruginosa

Anti-quorum Sensing Properties of Mushrooms

The LuxS/AI-2 system of Streptococcus suis

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