Quizartinib inhibits necroptosis by targeting receptor‐interacting serine/threonine protein kinase 1
Min Li,
Jun Wei,
Guofeng Zhu
et al.
Abstract:Systemic inflammatory response syndrome (SIRS), at least in part driven by necroptosis, is characterized by life‐threatening multiple organ failure. Blocking the progression of SIRS and consequent multiple organ dysfunction is challenging. Receptor‐interacting serine/threonine protein kinase 1 (RIPK1) is an important cell death and inflammatory mediator, making it a potential treatment target in several diseases. Here, using a drug repurposing approach, we show that inhibiting RIPK1 is also an effective treatm… Show more
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.