Quinpirole-induced sensitization to noisy/sparse periodic input: temporal synchronization as a component of obsessive-compulsive disorder

Gu, Bon-Mi; Cheng, Ruey‐Kuang; Yin, Bin; Meck, Warren H.

doi:10.1016/j.neuroscience.2011.01.048

Cited by 42 publications

(34 citation statements)

References 81 publications

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“…Moreover, pharmacological tests using dopamine D1/D5 and D2/D3 receptor agonists show that the lack of d-opioid receptors in the Oprd1 2/2 mice modifies the D1/D5-nigral/D2/D3-pallidal balance in the striatum in favour of the nigral output [1]. Hence, the facilitated acquisition of striataldependent tasks observed in Oprd1 2/2 mice is likely the result of potentiated dopaminergic/glutaminergic activity in striatonigral pathways-possibly involving striatal cholinergic interneurons [13,84,90,91]. As a consequence, the inclusion of the Oprd1 2/2 mice in this study strengthens the argument for hippocampal-striatal interactions as the source of the proportional leftward shifts produced by DH lesions.…”

Section: Discussion (A) Dorsal and Ventral Hippocampal Lesions Differmentioning

confidence: 99%

Comparison of interval timing behaviour in mice following dorsal or ventral hippocampal lesions with mice having δ -opioid receptor gene deletion

Yin

Meck

2014

Phil. Trans. R. Soc. B

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Mice with cytotoxic lesions of the dorsal hippocampus (DH) underestimated 15 s and 45 s target durations in a bi-peak procedure as evidenced by proportional leftward shifts of the peak functions that emerged during training as a result of decreases in both ‘start’ and ‘stop’ times. In contrast, mice with lesions of the ventral hippocampus (VH) displayed rightward shifts that were immediately present and were largely limited to increases in the ‘stop’ time for the 45 s target duration. Moreover, the effects of the DH lesions were congruent with the scalar property of interval timing in that the 15 s and 45 s functions superimposed when plotted on a relative timescale, whereas the effects of the VH lesions violated the scalar property. Mice with DH lesions also showed enhanced reversal learning in comparison to control and VH lesioned mice. These results are compared with the timing distortions observed in mice lacking δ -opioid receptors (Oprd1 −/− ) which were similar to mice with DH lesions. Taken together, these results suggest a balance between hippocampal–striatal interactions for interval timing and demonstrate possible functional dissociations along the septotemporal axis of the hippocampus in terms of motivation, timed response thresholds and encoding in temporal memory.

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Section: Discussion (A) Dorsal and Ventral Hippocampal Lesions Differmentioning

confidence: 99%

Comparison of interval timing behaviour in mice following dorsal or ventral hippocampal lesions with mice having δ -opioid receptor gene deletion

Yin

Meck

2014

Phil. Trans. R. Soc. B

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“…Moreover, individual differences in "memory-mixing" provide a unique opportunity to study the effects of instructional ambiguity, positive and negative feedback, as well as unimodal and bimodal distractors [46,47]. Such encoding processes may also provide a target for pharmacological investigation in select patient populations in which dopaminergic function can be manipulated, e.g., attention deficit hyperactivity disorder, obsessivecompulsive disorder, Parkinson's disease, and schizophrenia [48][49][50][51].…”

Section: Discussionmentioning

confidence: 99%

New Perspectives on Vierordt’s Law: Memory-Mixing in Ordinal Temporal Comparison Tasks

Meck

2011

Lecture Notes in Computer Science

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Abstract. Distortions in temporal memory can occur as a function of differences in signal modalities and/or by the encoding of multiple signal durations associated with different timing tasks into a single memory distribution -an effect referred to as "memory mixing". Evidence for this type of memory distortion and/or categorization of signal durations as an explanation for changes in temporal context (e.g., duration ranges), as well as for Vierordt's law (e.g., overestimation of "short" durations and underestimation of "long" durations), can be studied by examining proactive interference effects from the previous trial(s). Moreover, we demonstrate that individual differences in the magnitude of this "memory-mixing" phenomenon are correlated with variation in reaction times for ordinal temporal comparisons as well as with sensitivity to feedback effects in the formation of duration-specific memory distributions.

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“…Moreover, a core treatment for ADHD are various indirect dopamine agonists such as methylphenidate, methamphetamine, and nicotine, which as detailed above, have clear effects on interval timing (e.g., Conners et al, 1996;Levin et al, 1996Levin et al, , 1998Meck, 2007;Noreika et al, 2013). Dopaminergic signaling is involved in numerous diseases and neurological/ psychiatric conditions, such as depression, bipolar disorder, dystonia, drug addiction, Huntington's disease, obsessivecompulsive disorder, stuttering, Tourette's syndrome(e.g., Allman & Meck, 2012;Gu et al, 2011;Linazasoro & van Blercom, 2007;Ptáček et al, 2011;Singer et al, 2002). Furthermore, many commonly prescribed drugs powerfully modulate dopaminergic signaling.…”

Section: Clinical Correlationsmentioning

confidence: 99%

Clock Speed as a Window into Dopaminergic Control of Emotion and Time Perception

Cheng

Tipples

Narayanan

et al. 2016

Timing Time Percept

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Although fear-producing treatments (e.g., electric shock) and pleasure-inducing treatments (e.g., methamphetamine) have different emotional valences, they both produce physiological arousal and lead to effects on timing and time perception that have been interpreted as reflecting an increase in speed of an internal clock. In this commentary, we review the results reported by Fayolle et al. (2015): Behav. Process., 120, 135-140) and Meck (1983: J. Exp. Psychol. Anim. Behav. Process., 9, 171-201) using electric shock and by Maricq et al. (1981: J. Exp. Psychol. Anim. Behav. Process., 7, 18-30) using methamphetamine in a duration-bisection procedure across multiple duration ranges. The psychometric functions obtained from this procedure relate the proportion 'long' responses to signal durations spaced between a pair of 'short' and 'long' anchor durations. Horizontal shifts in these functions can be described in terms of attention or arousal processes depending upon whether they are a fixed number of seconds independent of the timed durations (additive) or proportional to the durations being timed (multiplicative). Multiplicative effects are thought to result from a change in clock speed that is regulated by dopamine activity in the medial prefrontal cortex. These dopaminergic effects are discussed within the context of the striatal beat frequency model of interval timing (Matell & Meck, 2004: Cogn. Brain Res., 21, 139-170) and clinical implications for the effects of emotional reactivity on temporal cognition (Parker et al., 2013: Front. Integr. Neurosci., 7, 75).

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Quinpirole-induced sensitization to noisy/sparse periodic input: temporal synchronization as a component of obsessive-compulsive disorder

Cited by 42 publications

References 81 publications

Comparison of interval timing behaviour in mice following dorsal or ventral hippocampal lesions with mice having δ -opioid receptor gene deletion

Comparison of interval timing behaviour in mice following dorsal or ventral hippocampal lesions with mice having δ -opioid receptor gene deletion

New Perspectives on Vierordt’s Law: Memory-Mixing in Ordinal Temporal Comparison Tasks

Clock Speed as a Window into Dopaminergic Control of Emotion and Time Perception

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