Quinoxaline Derivatives Anti-Cancer Activities Through Protein Kinases Inhibition: A review

Abstract

Benzopyrazines, commonly known as quinoxaline derivatives, are a significant group of heterocyclic compounds. Due to the vast range of biological activities that quinoxalines exhibit, they have received a lot of interest. Derivatives of quinoxaline (benzopyrazine), which contain the pyrazoline ring structure, are a class of physiologically active compounds. They demonstrated broad range of biological activities; anticancer, anti-inflammatory, antibacterial, antidepressant, hypoglycemic, hypotensive, and antihistamic because of their ability to serve as protein kinase inhibitors, they are regarded as crucial starting point for anticancer medicines. Since quinoxalines have been shown to be selective ATP-competitive inhibitors of numerous kinases, including the Epidermal growth factor receptor EGFR/HER2 inhibitors, vascular endothelial growth factor receptor (VEGFR), platelet-derived growth factor receptor (PDGFR), C-Met kinase inhibitor, Janus kinase receptor (JAK-2) and cyclin dependent kinase (CDK1,2,4,6). Quinoxaline derivatives' chemistry and their possible anti-protein kinase effects are the main topics of this paper.Anticancer / Kinase inhibitors / Quinoxalines derivatives.