Quinoxaline-annelated hexadehydro[12]annulene: use of a new building block to construct a hydrogen-bonded hexagonal molecular network

Kobayashi, Mayu; Kubo, Haruka; Oketani, Ryusei; Hisaki, Ichiro

doi:10.1039/d2ce00676f

Cited by 3 publications

(1 citation statement)

References 33 publications

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“…In addition, structural characteristics and easy synthetic accessibility of quinoxaline derivatives have been the major reasons for their applications as dyes, [16] electron luminescent substances, [17] organic semiconductors, [18] chemically controllable switches, [19] as building blocks for anion receptors, [20] cavitands, [21] dehydroannulenes, [22] DNA unzipping agents, [23] and also as subunits in macrocyclic receiver or in molecular diagnosis. [24] (Figure 2)…”

Section: Introductionmentioning

confidence: 99%

Advances in Isocyanide‐Based Multicomponent Synthesis of Quinoxaline Scaffolds

Agarwal,

Verma,

Pathak

et al. 2023

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The present review article includes recent advances in the synthesis of structurally and functionally diversified quinoxalines‐drug‐like small molecules with molecular complexity. We have extended our efforts to include the research work concerning the isocyanide‐based multicomponent reactions. The synthetic methods included in the present review article will provide an access for a diverse range of natural product mimetic scaffolds with the use of isocyanide‐.based combinatorial synthesis. These isocyanide based reactions will be significant for the synthesis of complex bioactive natural products and potential synthetic pharmaceuticals. The present review will contribute considerably to the organic syntheses and particularly drug discovery research including pharmaceutical and medicinal chemistry. Academically, the present review article will be interesting for the researchers engaged in design and development of isocyanide‐based organic transformations. Moreover, we hope that the isocyanide‐based multicomponent reactions will find major applications in industrially significant organic transformations and to develop new synthetic routes to facilitate the incorporation of heterocyclic substructures into pharmaceutically active molecules.

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Section: Introductionmentioning

confidence: 99%

Advances in Isocyanide‐Based Multicomponent Synthesis of Quinoxaline Scaffolds

Agarwal,

Verma,

Pathak

et al. 2023

ChemistrySelect

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Structural details of carboxylic acid-based Hydrogen-bonded Organic Frameworks (HOFs)

Suzuki,

Hisaki

2023

Polym J

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Crystalline porous molecular frameworks formed through intermolecular hydrogen bonding are often called hydrogen-bonded organic frameworks (HOFs) by analogy to metal organic frameworks (MOFs) and covalent organic frameworks (COFs). Although the origin may go back to the 1960s, HOFs have recently been investigated as a new family of functional porous materials. In this review, HOFs composed of tritopic, tetratopic, and hexatopic carboxylic acid derivatives are reviewed by considering structural aspects such as isostructurality. These derivatives typically form H-bonded hcb, dia, sql, hxl, and pcu networks depending on the numbers, positions, and orientations of the carboxy groups in the molecule. We show detailed structures for selected HOFs indicating the low-dimensional networks formed through H-bonding of the molecule and higher-dimensional structures formed by assembly of the network. The networks can be designed and predicted from the molecular structure, while the latter is still difficult to design. We hope that this review will contribute to the well-controlled construction of HOFs.

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