Quinoxaline: An insight into the recent pharmacological advances

Tariq, Sana; Somakala, Kanagasabai; Amir, Mohd

doi:10.1016/j.ejmech.2017.11.064

Cited by 144 publications

(64 citation statements)

References 46 publications

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“…anti-cancer, antimalarial, anti-inflammatory, antimicrobial, antiHIV, etc. [ 23 , 24 ]. The 6-thioguanine is an antimetabolite of purine analogue type, used in the treatment of acute leukemias due to its inhibition of DNA synthesis in cancer cells [ 25 , 26 ].…”

Section: Resultsmentioning

confidence: 99%

Dragon’s Blood Sap: Storage Stability and Antioxidant Activity

Escobar¹,

Prieto

Pardo-Figuerez³

et al. 2018

Molecules

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Currently, consumers are demanding additive-free, fresher, and more-natural products. Dragon’s Blood Sap (DBS), the deep red latex of the specie of tree Croton lechleri (Müll. Arg.), contains a high concentration of phenolic compounds of great interest for the food, pharmaceutical, and cosmetic industries. These chemical compounds are highly susceptible to degradation. Therefore, DBS storage stability and its photo-oxidation was studied by Fourier transform infrared spectroscopy (FT-IR) and UV-Vis spectrophotometry for 39 days at different temperatures (4–21 °C) and relative humidities (0–56%), as well as under UV light exposure. It was observed that the degradation of phenolic compounds was reduced at 0% relative humidity (RH), not showing a significant effect of temperature in the range studied. UV light irradiation degraded DBS in a 20%. DBS has an exceptional high and stable antioxidant content (≥93% inhibition percentage of DPPH), which makes it a unique property to consider the DBS as an antioxidant agent or ingredient for consumer products formulations.

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Section: Resultsmentioning

confidence: 99%

Dragon’s Blood Sap: Storage Stability and Antioxidant Activity

Escobar¹,

Prieto

Pardo-Figuerez³

et al. 2018

Molecules

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“…Quinoxalines are well-known nitrogen-containing heterocyclic compounds, and substituted quinoxalines are important ligands with transition metals (Achelle et al, 2013;Floris et al, 2017;Tariq et al, 2018). They act as chelating agents bearing ring complexes bounded by a benzene ring and a pyrazine ring.…”

Section: Chemical Contextmentioning

confidence: 99%

Crystal structure of 2,3-bis(4-methylphenyl)benzo[g]quinoxaline

2018

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The title compound, C 26 H 20 N 2 , was obtained during a search for newextended ligands with the potential to generate efficient phosphors with iridium(III) for organic light-emitting devices (OLEDs). The benzoquinoxaline ring system is almost planar (r.m.s. deviation = 0.076 Å ). A pseudo-twofold rotation axis runs through the midpoints of the C2-C3 and C9-C10 bonds. The two phenyl rings are twisted relative to the benzoquinoxaline ring system, making dihedral angles of 53.91 (4) and 36.86 (6) . In the crystal, C-HÁ Á Á (arene) interactions link the molecules, but no -interactions between aromatic rings are observed.

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“…[11][12] In this regard, Ajani [13] described the status of quinoxaline motifs as excellent pathfinders in therapeutic medicine. Recently, a recent advance on pharmacological activities of quinoxaline derivatives has been reviewed by Tariq et al [14] Among diverse striking biological properties, numerous 2-substituted and 2,3-disubstituted quinoxaline derivatives have been frequently reported to possess substantial anti-tubercular activity and have drawn considerable attention. [15][16][17][18] For example, Seitz et al [19] ever reported the synthesis of a series of novel quinoxaline derivatives, among which 4'-acetoxybenzyl 2-quinoxalinecarboxylate (1, Figure 1) showed potent activity against M. tuberculosis (Mtb).…”

Section: Introductionmentioning

confidence: 99%

A Facile Synthesis and M. tuberculosis Leucyl-tRNA Synthetase Inhi-bitory Activity of Novel 3-Arylvinylquinoxaline-2-carboxylic Acids

Li¹,

Dong²,

Qin³

et al. 2020

Chin. J. Org. Chem.

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In the present work, a simple and facile synthesis of a new series of 3-arylvinylquinoxaline-2-carboxylic acids has been achieved using the newly-synthesized ethyl 3-bromomethylquinoxaline-2-carboxylate as substrate through one-pot sequential Arbuzov/Horner-Wadsworth-Emmons (HWE)/ester hydrolysis reaction procedure. A primary in vitro evaluation for their inhibitory activity against Mycobacterium smegmatis (M. smegmatis) Leucyl-tRNA synthetase (Mtb LeuRS) revealed that (E)-3-(3-nitrostyryl)quinoxaline-2-carboxylic acid (5j) represented the most active compound in this round of effort with the IC 50 value of 14.7 μmol•L-1 , which was much superior to the reference drug AN2679, indicating the potential medicinal value for the exploration of novel Mtb LeuRS inhibitor. The results of molecular docking analyses using CDOCKER module of Discovery Studio (DS) software suggested that it could bind well to the active site of Mtb LeuRS. Moreover, the antitubercular assay against M. smegmatis also revealed that the nitro-substituted 5j has the best anti-tubercular activity with the minimum inhibitory concentration (MIC) value 15.6 μg/mL, being comparable with the reference rifampicin.

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Quinoxaline: An insight into the recent pharmacological advances

Cited by 144 publications

References 46 publications

Dragon’s Blood Sap: Storage Stability and Antioxidant Activity

Dragon’s Blood Sap: Storage Stability and Antioxidant Activity

Crystal structure of 2,3-bis(4-methylphenyl)benzo[g]quinoxaline

A Facile Synthesis and M. tuberculosis Leucyl-tRNA Synthetase Inhi-bitory Activity of Novel 3-Arylvinylquinoxaline-2-carboxylic Acids

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