Quinoxaline: A comprehension of current pharmacological advancement in medicinal chemistry

Novel quinoxaline derivatives as dual EGFR and COX-2 inhibitors: synthesis, molecular docking and biological evaluation as potential anticancer and anti-inflammatory agents

“…27 Moreover, quinoxaline moiety and its derivatives have received significant attention due to their wide spectrum of pharmaceutical and biological properties such as, among other insecticidal, antidepressant, antifungal, anticonvulsant, anthelmintic, anti-inflammatory, antiviral, antimalarial,antibacterial, antiprotozoal, and anticancer. 26,28–30 CQS (4-amino- N -(5-chloroquinoxalin-2-yl) benzenesulfonamide, NSC 339004) 31,32 and XK469 (2-[4-(7-chloroquinoxalin-2-yl)oxyphenoxy]propanoic acid, NSC 697887) 33,34 are examples of potent anticancer quinoxalines. Moreover, these compounds have been widely used in technology as dyes, chemical switches, electroluminescent materials, photo-initiators, cavitands and organic semiconductors.…”

“…Moreover, these compounds have been widely used in technology as dyes, chemical switches, electroluminescent materials, photo-initiators, cavitands and organic semiconductors. 26,28,29,35…”

“…27 Moreover, quinoxaline moiety and its derivatives have received signicant attention due to their wide spectrum of pharmaceutical and biological properties such as, among other insecticidal, antidepressant, antifungal, anticonvulsant, anthelmintic, anti-inammatory, antiviral, antimalarial,antibacterial, antiprotozoal, and anticancer. 26,[28][29][30] CQS (4-amino-N-(5-chloroquinoxalin-2-yl) benzenesulfonamide, NSC 339004) 31,32 and XK469…”

“…Moreover, these compounds have been widely used in technology as dyes, chemical switches, electroluminescent materials, photo-initiators, cavitands and organic semiconductors. 26,28,29,35 On the other hand, hydrazones are found in numerous of the bioactive heterocyclic compounds that are of very important use because of their several biological and clinical medicinal applications. 36,37 Hydrazone derivatives of heteroaromatic compounds have been proved to have, among other, antidepressant, antifungal, antimicrobial, antitubercular, anticonvulsant, analgesic, anti-inammatory, antimalarial, antiplatelet, cardio protective and antiviral with anticancer activities being of signicant interest.…”

Synthesis, In Vitro Antiproliferative Activity, and In Silico Evaluation of Novel Oxiranyl-Quinoxaline Derivatives

“…Quinoxaline derivatives show a wide range of therapeutic properties such as anti-infectious [ 12 , 13 ], anticancer [ 14 , 15 ], and many others [ 16 ] ensuring them a bright future in medicinal chemistry. Some of these derivatives are currently approved for human treatment: for instance, varenicline for tobacco cessation, brimonidine to treat open-angle glaucoma, and erdafitinib which is an FGFR inhibitor used to treat bladder cancer [ 17 ]. Others have undergone clinical trials, such as chloroquinoxaline sulphonamide (CQS) [ 18 ], a topoisomerase II poison like XK-469 [ 19 ], which has been evaluated against stage IV colorectal cancer and small-cell lung cancer.…”