Quinone-Derived π-Extended Phenazines as New Fluorogenic Probes for Live-Cell Imaging of Lipid Droplets

Moliner, Fabio De; King, Aaron; Dias, Gleiston G.; Lima, Guilherme Ferreira de; Simone, C. A. De; Júnior, Eufrânio N. da Silva; Vendrell, Marc

doi:10.3389/fchem.2018.00339

Cited by 20 publications

(15 citation statements)

References 68 publications

(60 reference statements)

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“…Exploiting natural products as intermediates, Moliner et al designed the phenazine P1 ( Figure 4 ) as an LD-specific probe [ 42 ]. P1 was reported to be environment-sensitive, and could report viscosity.…”

Section: Recent Developments In Lds’ Selective Fluorescent Probesmentioning

confidence: 99%

Recent Advances in Fluorescent Probes for Lipid Droplets

2018

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Lipid droplets (LDs) are organelles that serve as the storage of intracellular neutral lipids. LDs regulate many physiological processes. They recently attracted attention after extensive studies showed their involvement in metabolic disorders and diseases such as obesity, diabetes, and cancer. Therefore, it is of the highest importance to have reliable imaging tools. In this review, we focus on recent advances in the development of selective fluorescent probes for LDs. Their photophysical properties are described, and their advantages and drawbacks in fluorescence imaging are discussed. At last, we review the reported applications using these probes including two-photon excitation, in vivo and tissue imaging, as well as LDs tracking.

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Section: Recent Developments In Lds’ Selective Fluorescent Probesmentioning

confidence: 99%

Recent Advances in Fluorescent Probes for Lipid Droplets

2018

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“…In the last 15 years, there has been a lot of interest to modulate the optical properties of fluorescent scaffolds [ 110–113 ] (e.g., excitation/emission, water solubility, fluorescence lifetime) to generate probes with improved characteristics for in vivo imaging. In addition to widely used commercial fluorophores, such as cyanines or rhodamines, fluorophores with additional features have been developed.…”

Section: Biological Applications Of Fluorescent Cyclic Peptide Probesmentioning

confidence: 99%

“…In the last 15 years, there has been a lot of interest to modulate the optical properties of fluorescent scaffolds [110][111][112][113] model. [114] The groups of Vahrmeijer and Frangioni reported zwitterionic NIR fluorophores which were incorporated into cRGD peptides for tumor imaging ( Figure 4A).…”

Section: Fluorescent Cyclic Peptides Targeting Other Biomoleculesmentioning

confidence: 99%

Fluorescent cyclic peptides for cell imaging

2020

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Fluorescent cyclic peptides are excellent chemical scaffolds to build optical agents for molecular imaging. In addition to their favorable physicochemical properties, they can be modified with multiple organic fluorophores and generate useful probes for biological assays targeting specific proteins, namely receptors or enzymes. In this article, we review recent advances in the synthetic approaches for the preparation of fluorescent cyclic peptides as well as some of their applications in biological imaging, from in vitro live‐cell imaging studies to in vivo characterization of preclinical models.

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“…吩嗪又称为二苯并吡嗪. 有别于苯并吡嗪, 其吡嗪环两侧存在两个苯环, 共轭程度更大, 是良好的荧光发色团 , 可设计、合成荧光探针分子 , 用于金属离子 [111] 、阴离子 [112] 和中性分子 [113] 备 2,3-二氨基吩嗪 65 [114] , 再与芳香醛缩合 [115] , 如西北师范大学魏太保课题组 [116] 制备的能连续检测 Fe 3＋、 [117] . Khurana 课题组 [118] 制备的探针 67 (Scheme 24), 在 0.5 mol [39,82] 、pH [19,46] 以及溶液中同时含多种离子(Hg 2＋ -Cu 2＋ [59] 、Cu 2＋ -Cd 2＋ [96] 等) 的分析物检测, 在生物体内 [27,31] 与纯水相介质 [21,108] 的检测应用亦有报道.…”

Section: 吩嗪类荧光探针unclassified

Research Progress in Design, Synthesis and Application of Benzo Nitrogen-Containing Heterocyclic Fluorescent Probes

Wang¹,

Arulkumar²,

Chen³

et al. 2019

Chinese Journal of Organic Chemistry

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Benzo five-/six-membered nitrogen-containing heterocyclic compound with a rigid plane and a large conjugate structure can emit characteristic fluorescence in a variety of organic solvents and mixed solutions, and N, O, S heteroatoms in the structure can serve as binding sites for fluorescent probes. Therefore, in recent years, benzo nitrogen-containing heterocyclic compounds are increasingly becoming one of the research focuses in the field of fluorescent probes. From the perspective of starting materials, synthesis methods, molecular structure, interaction mechanism, benzo five-/ six-membered nitrogen-containing heterocyclic fluorescent probes containing the structure of benzoxazole, benzothiazole, benzimidazole, indole, carbazole, quinoline, benzopyrazine and phenazine are introduced with emphasis. And their detection application for a variety of analytes, such small molecules, metal cations, anions and pH are reviewed. In the future, it is worthy of further attention to the research on the integration of multiple heterocyclic functional structures into a multifunctional fluorescent probe by simple and green synthesis.

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Quinone-Derived π-Extended Phenazines as New Fluorogenic Probes for Live-Cell Imaging of Lipid Droplets

Cited by 20 publications

References 68 publications

Recent Advances in Fluorescent Probes for Lipid Droplets

Recent Advances in Fluorescent Probes for Lipid Droplets

Fluorescent cyclic peptides for cell imaging

Research Progress in Design, Synthesis and Application of Benzo Nitrogen-Containing Heterocyclic Fluorescent Probes

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