Quinone derivatives from the rhizomes of Acorus gramineus

Lee, Joe; Oh, Jy; Choi, Su Jin; Lee, KR

doi:10.1055/s-0032-1321283

Cited by 2 publications

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“…Owing to its biological activities and popular use, it is important to peform quantitative and qualitative studies of the constituents of ATS. Many studies have mainly focused on the analysis of sesquiterpenoids and phenylpropanoids from ATS (Lao et al ., ; Venskutonis and Dagilyte, ; Yu et al ., ; Lee et al ., and ; Deng et al ., ). Since high‐performance liquid chromatography–mass spectrometry (HPLC‐MS) has become a powerful tool for qualitative analysis of TCM and metabolites owing to its high resolution, accuracy and reproducibility (Ling et al ., ; Fu et al ., ; Chen et al ., ; Bagnall et al ., ; Martinez Bueno et al ., ; Qi et al ., ), we have developed a method using a high‐performance liquid chromatography coupled with electrospray ionization quadrupole time‐of‐flight mass spectrometry (HPLC/ESI‐QTOF‐MS/MS) technique for a comprehensive qualitative analysis of ATS.…”

Section: Introductionmentioning

confidence: 97%

Qualitative and quantitative analysis of the major constituents in Acorus tatarinowii Schott by HPLC/ESI‐QTOF‐MS/MS

Zhang

Pan

Xue

et al. 2014

Biomedical Chromatography

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Acorus tatarinowii Schott (ATS) is a well-known traditional Chinese medicine (TCM) for the treatment of epilepsy, amnesia and insomnia. In this study, a methodology utilizing high-performance liquid chromatography (HPLC) coupled with electrospray ionization quadrupole time-of-flight mass spectrometry (ESI-QTOF-MS/MS) was established for the separation and structural identification of the major chemical constituents in ATS for the first time. Overall, 46 major constituents including flavonoid glycosides, phenylpropane derivatives, amides and lignans were identified or tentatively characterized. Seven major constituents, including four phenylpropane derivatives and three lignans, were further quantified as marker substances, which showed good linearity within the test ranges. These results indicated that the developed quantitative method was linear, sensitive, and precise for quality control of ATS.

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Section: Introductionmentioning

confidence: 97%

Qualitative and quantitative analysis of the major constituents in Acorus tatarinowii Schott by HPLC/ESI‐QTOF‐MS/MS

Zhang

Pan

Xue

et al. 2014

Biomedical Chromatography

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“…Thus, licorice extract can prevent damage of gastric mucosal cells by increasing hexose in these cells, which therefore inhibits the growth of H. pylori in vitro [ 25 ]. Acorus gramineus can initiate digestion and inhibit urease activity that cause stomach ache and suppress bacteria [ 26 ]. Fructus foeniculi can reduce flatulence, relieving pain, resisting inflammation, protecting cells, and regulating gastrointestinal motility in gastrointestinal disorders associated with H. pylori [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

Efficacy and Safety of Wei Bi Mei, a Chinese Herb Compound, as an Alternative to Bismuth for Eradication of Helicobacter pylori

Meng

Zhu

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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Bismuth-containing quadruple therapy has been recommended as the first line of treatment in areas of high clarithromycin or metronidazole resistance. However, safety concerns of bismuth agents have long been raised. We first assessed the efficacy and safety of Wei Bi Mei granules, which are bismuth compounds consisting of three synthetic drugs and five medicinal herbs, compared to bismuth aluminate and colloidal bismuth subcitrate (CBS) in H. pylori-infected mouse model. We then used atomic fluorescence spectroscopy and autometallography to measure the accumulation of three bismuth agents in the brain, heart, liver, and kidneys in adult Sprague-Dawley rats. We also evaluated the safety of bismuth agents by conducting clinical biochemistry tests in blood samples of experimental animals. Wei Bi Mei granules exhibited the highest efficacy of anti-H. pylori activity and yielded the lowest bismuth accumulation when compared to CBS and bismuth aluminate. Our findings show that Wei Bi Mei granules are a safe Chinese medicinal herb with potent anti-H. pylori activity and can be considered as an alternative to current bismuth compounds. Thus, Wei Bi Mei granules merit further evaluation, particularly with regard to efficacy and safety when they are combined with other H. pylori eradication medications in the clinical setting.

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Quinone derivatives from the rhizomes of Acorus gramineus

Cited by 2 publications

References 0 publications

Qualitative and quantitative analysis of the major constituents in Acorus tatarinowii Schott by HPLC/ESI‐QTOF‐MS/MS

Qualitative and quantitative analysis of the major constituents in Acorus tatarinowii Schott by HPLC/ESI‐QTOF‐MS/MS

Efficacy and Safety of Wei Bi Mei, a Chinese Herb Compound, as an Alternative to Bismuth for Eradication of Helicobacter pylori

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