Quinone compounds regulate the level of ROS production by the NADPH oxidase Nox4

Nguyen, Minh Vu Chuong; Lardy, Bernard; Rousset, Francis; Hazane-Puch, Florence; Zhang, Leilei; Trocmé, Candice; Serrander, Lena; Krause, Karl‐Heinz; Morel, Françoise

doi:10.1016/j.bcp.2013.03.023

Cited by 33 publications

(25 citation statements)

References 50 publications

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“…Oxidative stresses caused by ROS can induce rapid depolarization of bacteria cells. In the redox process of the quinonoid compound, superoxide anions are the most likely chemical species to be formed in the oxide stage . To investigate this possibility, we monitored superoxide production using the NBT assay (Fig.…”

Section: Resultsmentioning

confidence: 99%

Humic analog AQDS can act as a selective inhibitor to enable anoxygenic photosynthetic bacteria to outcompete sulfate‐reducing bacteria under microaerobic conditions

Wang

Cheng

Ren

et al. 2015

J of Chemical Tech & Biotech

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BACKGROUND The anoxygenic photosynthetic bacteria (APB) process is considered the most promising candidate for cost‐effective wastewater treatment and resource recovery. One major problem in the APB process with sulfate‐containing wastewater is the overgrowth of sulfate‐reducing bacteria. In this study, the humic analog anthraquinone‐2,6‐disulfonate (AQDS) was used to selectively inhibit sulfate‐reducing bacteria (SRB) in an SRB and APB coculture. RESULTS The addition of 1.0 mmol L−1 AQDS to the SRB and APB coculture resulted in significant decreases in the amount of SRB and the sulfide concentration, whereas the number of APB increased from 3.7 × 103 to 3.1 × 108 CFU mL−1. A high concentration of AQDS negatively affected the growth of both SRB and APB but more strongly inhibited the growth of SRB. The inhibition of SRB by AQDS relies on an electron donor and is enhanced by illumination. AQDS treatment at 1.0 mmol L−1 induced significant membrane depolarization and superoxide production in SRB cells but not in APB cells, and this may be responsible for the selective inhibition of SRB in the coculture. CONCLUSION At appropriate concentrations, AQDS can decrease the concentration of sulfide and induce oxidative stress for SRB, effectively allowing APB to out‐compete SRB under microaerobic conditions. © 2015 Society of Chemical Industry

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Section: Resultsmentioning

confidence: 99%

Humic analog AQDS can act as a selective inhibitor to enable anoxygenic photosynthetic bacteria to outcompete sulfate‐reducing bacteria under microaerobic conditions

Wang

Cheng

Ren

et al. 2015

J of Chemical Tech & Biotech

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“…Since PAHs leads to reticulum stress (Laing et al 2010), the expression of NOX4 mRNA could be induced (Bedard and Krause 2007), contributing to the O 2 − production. Actually, recent studies showed that quinone compounds, like the intermediates of PAHs metabolism, regulate the O 2 − production by NOX4 (Nguyen et al 2013). …”

Section: Discussionmentioning

confidence: 98%

Organic compounds present in airborne particles stimulate superoxide production and DNA fragmentation: role of NOX and xanthine oxidase in animal tissues

Busso

Silva

Carreras

2016

Environ Sci Pollut Res

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Suspended particulate matter trigger the production of reactive oxygen species. However, most of the studies dealing with oxidative damage of airborne particles focus on the effects of individual compounds and not real mixtures. In order to study the enzymatic superoxide production resulting from the exposition to a complex mixture, we derived organic extracts from airborne particles collected daily in an urban area and exposed kidney, liver, and heart mammal tissues. After that, we measured DNA damage employing the comet assay. We observed that in every tissue, NADPH oxidase and xanthine oxidase were involved in O2 (-) production when they were exposed to the organic extracts, as the lucigenin's chemiluminescence decays when enzymes were inhibited. The same trend was observed with the percentage of cells with comets, since DNA damage was higher when they were exposed to same experimental conditions. Our data allow us to hypothesize that these enzymes play an important role in the oxidative stress produced by PAHs and that there is a mechanism involving them in the O2 (-)generation.

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“…NADPH oxidase exists in a wide range of tissues and plays a role in cellular signaling by generating ROS [27]. Another study indicated some specific quinine derivatives could modulate the activity of NADPH oxidase [28].…”

Section: Discussionmentioning

confidence: 99%

An Oxidative Stress Mechanism of Shikonin in Human Glioma Cells

Yang

et al. 2014

PLoS ONE

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Shikonin is a quinone-containing natural product that induces the apoptotic death of some cancer cell lines in culture through increasing intracellular reactive oxygen species (ROS). Quinone-based drugs have shown potential in the clinic, making shikonin an interesting compound to study. Our previous study found that shikonin induces apoptosis in neuroblastoma by induction of ROS, but its mechanism of action and scope of activity are unknown. In this study, we investigated the mode of oxidative stress of shikonin in human glioma cells. ROS induction by shikonin was of mitochondrial origin, as demonstrated by detection of superoxide with MitoSOX Red. Pre-incubation of shikonin with inhibitors of different complexes of the respiratory chain suggested that shikonin-induced ROS production occurred via complex II. In addition, NADPH oxidase and lipooxygenase are two other main ROS-generated sites in shikonin treatment. ROS production by shikonin resulted in the inhibition of nuclear translocation of Nrf2. Stable overexpression of Nrf2 in glioma cells inhibited ROS generation by shikonin. ROS generation from mitochondrial complex II, NADPH oxidase and lipooxygenase is likely the primary mechanism by which shikonin induces apoptosis in glioma cells. These findings also have relevance to the development of certain ROS producers as anti-cancer agents. These, along with shikonin have potential as novel chemotherapeutic agents on human glioma.

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Quinone compounds regulate the level of ROS production by the NADPH oxidase Nox4

Cited by 33 publications

References 50 publications

Humic analog AQDS can act as a selective inhibitor to enable anoxygenic photosynthetic bacteria to outcompete sulfate‐reducing bacteria under microaerobic conditions

Humic analog AQDS can act as a selective inhibitor to enable anoxygenic photosynthetic bacteria to outcompete sulfate‐reducing bacteria under microaerobic conditions

Organic compounds present in airborne particles stimulate superoxide production and DNA fragmentation: role of NOX and xanthine oxidase in animal tissues

An Oxidative Stress Mechanism of Shikonin in Human Glioma Cells

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